Investigation of TLR1-9 genes and miR-155 expression in dogs infected with canine distemper

Daldaban, Fadime; Bekdik, İlknur Karaca; Aslan, Öznur; Akyüz, Bilal; Akçay, Aytaç; Arslan, Korhan

doi:10.1016/j.cimid.2021.101711

Cited by 6 publications

(5 citation statements)

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“…However, our NEU%, LYM%, and EOS% values were increased in the CDV infected dogs. Another important parameter PLT levels were also stated in the reference in our study dogs same as others (Daldaban et al, 2021). PLT has a main role of platelets in inflammation and infection which they modulate leukocytosis function by phagocytosis (Jenne & Kubes, 2015).…”

Section: Discussionsupporting

confidence: 83%

“…There was a significant anemia found in our CDV infected dogs. Thus, there was a decrease seen in RBC, HGB, MCH and MCHC values in the CDV infected dogs, which shows combability with the other studies (Ezeibe & Udegbunam, 2008;Willi et al, 2015;Daldaban et al, 2021). Anemia observed in the CDV infected dogs could be explained by the over production of inflammatory mediators, which could inhibit erythropoiesis and shorten RBC life span (Meyer and Harvey, 1998).…”

Section: Discussionsupporting

confidence: 78%

“…Another study which investigated haematologic parameters in the CDV infected dogs showed that there was a remarkable anaemia and lymphopenia in dogs infected with CDV (Ezeibe & Udegbunam, 2008). A decrease in RBC, HGB, MCH and MCHC values and a mild normochromic, normocytic anemia in the pretreatment haemogram analyzes was also observed in the dogs infected with CDV in a recent study (Daldaban et al, 2021).…”

Section: Discussionmentioning

confidence: 54%

“…PLT has a main role of platelets in inflammation and infection which they modulate leukocytosis function by phagocytosis (Jenne & Kubes, 2015). Daldaban et al (2021) also reported that PLT has roles in the development of clinical findings in the acute phase of CD and in the formation of immunity against the virus, especially with TLR4 gene expression. Moreover, it is known local disturbance of blood circulation that compromises congestion, edema, thrombosis, and the existence of disseminated intravascular coagulation in CDV infected dogs' grey matter, white matter, and meninges (Pan et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

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A Preliminary Study for Determination of Neutrophil to Lymphocyte, Monocyte to Lymphocyte and Platelet to Lymphocyte Ratios in Dogs with Canine Distemper Virus Infection

Pekmezci

KONAÇOĞLU

Colak

2022

Journal of Anatolian Environmental and Animal Sciences

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It is aimed to compare the pretreatment Neutrophil/Lymphocyte (NEU/LYM), Monocyte/Lymphocyte (MONO/LYM), and Platelet/Lymphocyte (PLT/LYM) ratios with whole blood count (WBC) of dogs naturally infected Canine Distemper Virus (CDV) with healthy individuals within this preliminary study. For this purpose, retrospectively, 22 owned, 3-12 (6.2) months old dogs diagnosed with CDV infection found to be positive with rapid test kits based up on the records of Animal Hospital, Faculty of Veterinary Medicine, constituted the study group. On the other hand, eight owned, 2-10 (8.2) months old, and healthy dogs enrolled in the control group. In the comparison of pre-treatment NEU/LYM, MONO/LYM, PLT/LYM, and WBC parameters between the groups, we found only a statistical difference (P 0.05) between median LYM, EOS, NEU%, LYM%, EOS%, BAS%, MCH, MCHC, RDWCV, PLT with NEU/LYM, MONO/LYM, PLT/LYM ratios. The median NEU/LYM, MONO/LYM, and PLT/LYM levels in the CDV positive group were 31.9, 2.33, and 391.2, respectively, while the same values of the control group were determined as 6.39, 0.37 and 187.7, respectively. The optimized cut-off points of NEU/LYM, MONO/LYM, and PLT/LYM values in estimating CDV patients were also determined as NEU/LYM =7.6, MONO/LYM=0.61 and PLT/LYM=0.852, respectively. In conclusion, this preliminary study suggests that NEU/LYM, MONO/LYM, and PLT/LYM values may be inexpensive, objective, and non-invasive new marker candidates for clinicians to support the diagnosis of CDV infected dogs in suspicious circumstances.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

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A Preliminary Study for Determination of Neutrophil to Lymphocyte, Monocyte to Lymphocyte and Platelet to Lymphocyte Ratios in Dogs with Canine Distemper Virus Infection

Pekmezci

KONAÇOĞLU

Colak

2022

Journal of Anatolian Environmental and Animal Sciences

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“…More specifically, drugs commonly prescribed for this condition include ibuprofen and oral contraceptives. However, the failure rate of these drugs is as high as 25% due to contraindications or intolerance [3]. Moreover, these medications are associated with a high risk of adverse side effects.…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture treatment of primary dysmenorrhea: A randomized, participant-blinded, sham-controlled clinical trial protocol

et al. 2023

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Background Primary dysmenorrhea in women is a common and serious public health problem with psychological and physical effects. Painkillers have adverse effects, such as tolerance, addiction, irritation of the digestive tract, and liver and kidney damage. Electroacupuncture has been used as alternative therapy, although with no (non-anecdotal) evidence of effectiveness. Objective This study aims to provide evidence for the feasibility and efficacy of electroacupuncture in the treatment of primary dysmenorrhea. Moreover, by observing changes in serum and urine metabolites, we will evaluate the putative mechanisms mediating electroacupuncture effects in primary dysmenorrhea. Methods This multicenter, randomized, participant-blinded, sham-controlled clinical trial including 336 women with primary dysmenorrhea is being conducted at three hospital centers in China and consists of a 12-week treatment and a 3-month follow-up. Women will undergo electroacupuncture (n = 168) or sham acupuncture (n = 168), beginning 7 days before their menstruation, once per day, until menstruation. Each menstrual cycle equals one course of treatment, and we will evaluate a total of three courses of treatment. The primary outcome of interest is the change in visual analogue scale scores before and after treatment. The secondary outcomes include changes in the numeric rating scale, Cox Menstrual Symptom Scale, traditional Chinese medicine symptoms, the Self-Rating Anxiety Scale, Self-Rating Depression Scale, and 36-Item Short Form questionnaire scores, and a safety evaluation. Moreover, we will preliminarily investigate the metabolomics mechanism as a potential mediator of the association between electroacupuncture and primary dysmenorrhea symptomology. Discussion We aim to find a suitable non-medicinal alternative for primary dysmenorrhea treatment to reduce reliance on non-steroidal anti-inflammatory drugs. Trial registration Chinese Clinical Trial Registry: ChiCTR2100054234; http://www.chictr.org.cn/.

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Noticeable immune dysregulation-and-suppression in parvovirus affected dogs

Shahbazi Asil,

Zarifian,

Valafar

et al. 2023

Veterinary Immunology and Immunopathology

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Investigation of TLR1-9 genes and miR-155 expression in dogs infected with canine distemper

Cited by 6 publications

References 50 publications

A Preliminary Study for Determination of Neutrophil to Lymphocyte, Monocyte to Lymphocyte and Platelet to Lymphocyte Ratios in Dogs with Canine Distemper Virus Infection

A Preliminary Study for Determination of Neutrophil to Lymphocyte, Monocyte to Lymphocyte and Platelet to Lymphocyte Ratios in Dogs with Canine Distemper Virus Infection

Electroacupuncture treatment of primary dysmenorrhea: A randomized, participant-blinded, sham-controlled clinical trial protocol

Noticeable immune dysregulation-and-suppression in parvovirus affected dogs

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