Investigation of trefoil factor expression in saliva and oral mucosal tissues of patients with oral squamous cell carcinoma

Chaiyarit, Ponlatham; Utrawichian, Akasith; Leelayuwat, Chanvit; Vatanasapt, Patravoot; Chanchareonsook, Nattharee; Samson, Mie Hessellund; Giraud, Andrew S.

doi:10.1007/s00784-011-0667-z

Cited by 22 publications

(28 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the present findings are in contrast with our previous observations [18] demonstrating the reduction of TFF2 and TFF3 in oral squamous cell carcinoma (OSCC) lesions of oral mucosa. These findings and the clear inhibition of TFF1 and TFF2 in gastric cancer [37,38], suggest diverse regulation and function of TFF proteins under tumorigenic conditions in different luminal compartments.…”

Section: Discussioncontrasting

confidence: 99%

“…Although compelling evidence from experimental and clinical studies indicates a strong association between TFFs and human cancers, very little is known about the role of TFFs in oral cancers. Our previous study demonstrated that TFF2 and TFF3 expression was significantly decreased in oral squamous cell carcinoma (OSCC) [18]. These findings suggest a possible tumor suppressive role of TFF2 and TFF3 in OSCC.…”

Section: Introductionmentioning

confidence: 90%

See 1 more Smart Citation

Increased immunoexpression of trefoil factors in salivary gland tumors

et al. 2013

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 90%

Increased immunoexpression of trefoil factors in salivary gland tumors

et al. 2013

Self Cite

View full text Add to dashboard Cite

show abstract

“…*P = 0.006, **P = 0.002. 1 2 7 18 -3 1 16 19 23 15 15 24 2 10 5 5 2 12 5 3 8 9 --8 3 Reduced immunoreactivity of TFF2 and 3 in the oral epithelia of OLP patients as demonstrated in the present study, is in agreement with our previous observations showing a similar inhibition of these trefoils in inflamed mucosal tissues of patients with oral squamous cell carcinoma [5]. These findings imply a possible connection between inflamed oral epithelia of patients with OLP and a malignant transformation risk for oral squamous cell carcinoma.…”

Section: Discussionsupporting

confidence: 82%

“…However, the exact mechanisms of chronic immune-mediated inflammation and malignant transformation of OLP remain unclear. Our recent study demonstrated reduced TFF3 and TFF2 in the oral mucosa of patients with oral squamous cell carcinoma, which were associated with chronic inflammation [5]. In addition, we found the reduction of TFF3 in inflamed gingival tissues of patients with chronic periodontitis [6].…”

Section: Brief Communication (Original)supporting

confidence: 52%

“…NF-κB signaling pathways and proinflammatory cytokines such as interleukin (IL)-1β and IL-6 are implicated in the downregulation of TFF [3], whereas Src homology 2 domaincontaining Src homology tyrosine phosphatase (SHP2)/extracellular signal-regulated kinase (Erk) signaling pathways are involved in stimulation of TFF expression [4]. TFFs are detected in various oral compartments, including the oral mucosa, gingival tissues, and saliva [5,6]. Salivary TFFs originate mainly from salivary glands, with minor contributions from parotid duct component goblet and epithelial cells [7][8][9][10][11].…”

Section: Brief Communication (Original)mentioning

confidence: 99%

See 1 more Smart Citation

Brief communication (Original). Trefoil factor expression by immunohistochemistry in patients with oral lichen planus

et al. 2014

Self Cite

View full text Add to dashboard Cite

Background: Oral lichen planus (OLP) is a chronic immune-mediated inflammatory disease that usually causes oral mucosal damage. OLP has been considered to be a potentially malignant disorder associated with an increased risk for oral cancer. Trefoil factors (TFFs) are mainly synthesized by mucin-producing epithelial cells. Expression of TFFs in oral epithelia is thought to be an essential factor in protection against oral mucosal damage. However, very little is known about the connection between tissue damage of oral mucosa in OLP patients and expression of TFFs. Objectives: To determine levels of TFF expression in oral mucosa from patients with OLP. Methods: Tissue samples were collected from 35 patients with normal oral mucosa (controls) and 35 patients with OLP. An immunohistochemical method was used to determine the expression of the 3 TFFs (TFF1, 2, and 3) in mucosal tissues of the oral cavity. Results: TFF2 and TFF3 expression in oral epithelia were significantly decreased in OLP patients (MannWhitney U test; P = 0.006, and P = 0.002, respectively). There were no significant differences in TFF1 expression between OLP patients and control subjects. Conclusion:The present study demonstrated reduced expression of TFF2 and TFF3 in oral epithelia of OLP patients. These outcomes support our previous observations that chronic inflammation may play a major role in downregulation of TFF expression, which may be associated with oral mucosal damage in OLP patients.

show abstract

Salivary trefoil factor family peptide 3 (TFF3) and flow rate in persons with and without obstructive sleep apnea: A preliminary study

Ruangsri,

Doolgindachbaporn,

Chokwatwikul

et al. 2023

Clinical & Exp Dental Res

View full text Add to dashboard Cite

ObjectivesObstructive sleep apnea (OSA) is one of the most common chronic diseases. Trefoil factor family 3 (TFF3) peptides are secreted by major and minor salivary glands and may be involved in the pathogenesis of OSA. This study aimed to evaluate salivary TFF3 and flow rate between those with and without OSA.Material and methodsThis was a prospective experimental study that enrolled patients with OSA and non‐OSA. Total unstimulated saliva was collected, the salivary flow rate was measured, and the TFF3 level was analyzed by using a modified sandwich enzyme‐linked immunosorbent assay. Baseline characteristics, TFF3 level, and salivary flow rate were compared between both groups. Factors associated with the TFF3 level and flow rate were computed by using multivariate linear regression analysis.ResultsTwenty‐eight participants were recruited in the study: 20 patients with OSA (71.42%) and 8 non‐OSA as control. The TFF3 and salivary flow rates between both groups of non‐OSA versus OSA were comparable (TFF3 non‐OSA 61.06 vs. OSA 96.00 ng/mg; p = .276 and flow rate non‐OSA 0.40 vs. OSA 0.35 mL/min; p = .320). Factors associated with the TFF3 level were neck circumference with a negative coefficient of −16.419 (p = .042). For the salivary flow rate, only age was a significant factor with the coefficient of −0.013 (p = .044).ConclusionsTFF3 and salivary flow rate were comparable between patients with OSA and non‐OSA. The factor associated with TFF3 level was neck circumference, while age was negatively associated with the salivary flow rate in patients with OSA.

show abstract

Investigation of trefoil factor expression in saliva and oral mucosal tissues of patients with oral squamous cell carcinoma

Abstract: These findings suggest the clinical significance of TFF2 and TFF3 molecules as negative markers of tumor progression in OSCC. Quantification of TFF levels in saliva may not be optimal in terms of diagnostic or predictive value for OSCC derived from oral mucosa.

Cited by 22 publications

References 49 publications

Increased immunoexpression of trefoil factors in salivary gland tumors

Increased immunoexpression of trefoil factors in salivary gland tumors

Brief communication (Original). Trefoil factor expression by immunohistochemistry in patients with oral lichen planus

Salivary trefoil factor family peptide 3 (TFF3) and flow rate in persons with and without obstructive sleep apnea: A preliminary study

Contact Info

Product

Resources

About