Investigation of variables associated with medication nonadherence in patients with hypertension

Jarab, Anan S.; Alefishat, Eman; Nasur, Rasha Bani; Mukattash, Tareq L.

doi:10.1111/jphs.12236

Cited by 7 publications

(10 citation statements)

References 30 publications

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“…The majority of the current study participants (≈ 73%) reported non-adherence to the prescribed medications. The rate of non-adherence reported in the present study is comparable with earlier studies conducted on patients with hypertension (81%) [ 21 ], diabetes (72.5%) [ 20 ], and angina (79.4%) [ 28 ], using the validated Arabic version of the 4-item medication adherence scale in Jordan. The high non-adherence rate reported in this study sheds light on the necessity to develop effective pharmaceutical care intervention programs aimed at improving medication adherence and hence, health outcomes in patients with dyslipidemia in Jordan.…”

Section: Discussionsupporting

confidence: 88%

“…Patients with strong concerns about medications’ side effects, dependence, and disruption of daily activities are more likely to be non-adherent to the prescribed medications [ 31 ]. Consistent with this finding, previous studies reported that patients who were concerned about the potential side effects of their prescribed medications were found to be more likely to be non-adherent to their medications among patients with hypertension [ 21 , 33 , 34 , 35 , 36 ], diabetes [ 20 ], metabolic syndrome [ 37 ], and COPD [ 36 ]. A previous study found that the most common reason behind statin discontinuance were concerns about side effects, represented as muscle aches and gastrointestinal disorders [ 38 ].…”

Section: Discussionsupporting

confidence: 71%

“…Poor adherence to lipid-lowering therapy is associated with adverse cardiovascular effects, increased mortality, and increased healthcare costs [ 27 ]. Earlier studies have explored variables associated with medication non-adherence in patients at high risk for ASCVD, such as hypertension [ 21 ] and diabetes [ 20 ], in Jordan. The present study is the first to evaluate medication adherence and investigate the factors associated with medication non-adherence in patients with dyslipidemia in Jordan.…”

Section: Discussionmentioning

confidence: 99%

“…Understanding the factors associated with medication non-adherence can augment efforts to improve it [ 19 ]. Although several studies have been conducted to explore variables associated with medication non-adherence in patients with high risk for ASCVD such as hypertension and diabetes in Jordan [ 20 , 21 ], there is no reported date on medication non-adherence and its associated factors among patients with dyslipidemia in Jordan. Therefore, the present study aimed to evaluate medication non-adherence and explore its associated variables among patients with dyslipidemia in Jordan.…”

Section: Introductionmentioning

confidence: 99%

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Factors Associated with Medication Non-Adherence in Patients with Dyslipidemia

et al. 2021

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Lack of medication adherence among patients with dyslipidemia negatively affects health-related outcomes. This study aims to evaluate medication adherence; we also aim to investigate the predictors of non-adherence among patients with dyslipidemia in Jordan. Medication adherence was evaluated in a total of 228 dyslipidemia patients. The Beliefs about Medicines Questionnaire was also used to assess patients’ beliefs about medications. The majority of the current study participants (73.2%) reported non-adherence to the prescribed medications. There were significant negative associations between medication adherence and concerns of prescription drug use (B = −0.41, p-value < 0.01), duration of dyslipidemia (B = −0.22, p-value < 0.01), and the number of medications (B = −0.64, p-value < 0.01). Positive associations were found between medication adherence and the necessity of prescription drug use (B = 0.43, p-value < 0.01), taking statin and fibrate (B = 2.04, p-value < 0.01), and moderate-intensity statin (B = 2.34, p-value < 0.01). As for patients’ beliefs about medications, the item “My medicine to lower my cholesterol disrupted my life” had the highest mean (3.50 ± 0.99). This study revealed a low adherence rate to medication among patients with dyslipidemia. It also demonstrates modifiable factors such as beliefs regarding perceived risk, medication harms, treatment duration, and the number of medications associated with poor adherence in patients with dyslipidemia.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Factors Associated with Medication Non-Adherence in Patients with Dyslipidemia

et al. 2021

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“…The Morisky scale has been validated in Arabic language, and it has been used to assess medication adherence in patients with different chronic diseases in Jordan such as hypertension and diabetes mellitus …”

Section: Methodsmentioning

confidence: 99%

Non‐adherence to pharmacotherapy and its associated factors among patients with angina in Jordan

Jarab

Rababa’h

Almousa

et al. 2020

J Pharm Health Serv Res

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Objective The study aim was to explore factors associated with medication non‐adherence in patients with angina in Jordan. Methods The current study was conducted in the outpatient cardiac clinic at the Royal Medical Services Hospital in Amman. Variables including socio‐demographics, biomedical variables in addition to disease and therapy factors were collected for 500 patients with angina using medical records and custom‐designed questionnaire. Medication adherence was assessed using the validated 4‐item Morisky Medication Adherence Scale. Logistic regression was performed to develop a model with variables that best predicted medication non‐adherence. Key findings The majority of the study patients (79.4%) were found non‐adherent to the prescribed medications. Regression analysis identified duration of illness (P < 0.037; OR = 1.090) and number of chronic diseases (P < 0.035; OR = 1.621) as significant predictors of medication non‐adherence. Conclusion Clinical pharmacists should focus on improving medication adherence for patients with angina. Patients who have longer duration of angina and those with multiple comorbid diseases should be specifically targeted in future pharmaceutical care programmes designed to improve health outcomes for patients with angina in Jordan.

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Pharmacology for cardiovascular nurses

Keenan¹,

Khatib²,

McKee³

et al. 2021

ESC Textbook of Cardiovascular Nursing

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Pharmacological therapies are the mainstay in the management of primary and secondary prevention of cardiovascular disease. Nurses have an important role in medicines management in collaboration with professional colleagues, particularly physicians and pharmacists. Training nurses in advanced practice skills in relation to medications can improve post-acute event care. Approaches to nursing and allied health professional prescribing are described in three different ways, referred to as ‘independent’, ‘supplementary’, and ‘dependent’ prescribing. Up to half of patients prescribed medication for long-term conditions are not adherent to their prescribed regimen. It is important for nurses to identify the reason for non-adherence before attempting to implement strategies to address it. In cases of intentional non-adherence, it is essential to address patients’ beliefs or concerns, or advocate for the patient to have the treatment plan modified to an approach that fits the patient’s needs. Medications used in cardiovascular care include lipid-lowering agents, anticoagulants, antiplatelets, antiarrhythmics, new drugs to treat diabetes with cardiovascular benefits, drugs used to promote tissue perfusion, drugs that affect the renin–angiotensin–aldosterone system, beta-blockers, calcium channel blockers, and those used in emergencies and cardiogenic shock.

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Investigation of variables associated with medication nonadherence in patients with hypertension

Cited by 7 publications

References 30 publications

Factors Associated with Medication Non-Adherence in Patients with Dyslipidemia

Factors Associated with Medication Non-Adherence in Patients with Dyslipidemia

Non‐adherence to pharmacotherapy and its associated factors among patients with angina in Jordan

Pharmacology for cardiovascular nurses

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