Investigation of water uptake behavior and stability of calcium alginate/chitosan bi-polymeric beads: Part-1

Bajpai, Sunil; Tankhiwale, Rasika

doi:10.1016/j.reactfunctpolym.2005.10.017

Cited by 105 publications

(63 citation statements)

References 28 publications

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“…However, the more strengthened microparticle structure provided by CS was not able to remove completely the burst effect in the neutral pH. At this pH value, chitosan has less free amine groups due to the increased deprotonation providing a less strong interaction with alginate (Bajpai & Tankhiwale, 2006).…”

Section: In Vitro Drug Release Studymentioning

confidence: 93%

Microparticulate polyelectrolyte complexes for gentamicin transport across intestinal epithelia

et al. 2010

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Section: In Vitro Drug Release Studymentioning

confidence: 93%

Microparticulate polyelectrolyte complexes for gentamicin transport across intestinal epithelia

et al. 2010

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“…The weight drying show that the wet beads contain of 96.48% water. When left in water to swell the beads regained 2.35% of water (Bajpai and Tankhiwale, 2006). Immobilization of biomass: Aspergillus lentulus was immobilized by mixing sodium alginate, gelatin with above resting biomass in the ratio of 1:1:5.…”

Section: Synthesis Of Various Polymeric Particles As Carrier For Biommentioning

confidence: 99%

Economically Viable Fungal Production by Using Alternative Plant Material for the Removal of Heavy Metal

Jha¹,

Dikshit²

2015

J. of Environmental Science and Technology

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Environmental pollution affects the quality of atmosphere, lithosphere and biosphere. Efforts have been made in the last two decades to reduce the pollution sources and remedy the polluted water sources. Water quality monitoring in developing countries is inadequate especially in stream water affected by urban effluent and runoff. The purpose of this study was to investigate heavy metal contaminants in sank stream water in Gwalior. The water sample from stream and industrial effluents that drain into the stream were collected and analyzed for the total elemental concentration using atomic absorption spectrophotometer. The result showed that:-the wastewater was highly encircled with copper above the maximum permissible limit. 2) the level of dissolved oxygen was below the maximum permissible limit, while biological oxygen demand was above the maximum permissible limit. All industrial effluents/wastewater were classified as strong. Factors analysis results reveal two sources of pollutants; multiple origin of copper and mixed origin or chemical phenomena of industrial and vehicular emission.

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“…The beads that were additionally treated with sodium alginate (F6 and F9) were found to be clumpy after washing. An extra treatment with CaCl 2 (0.5 %, m/V) also resulted in smooth and spherical beads (F7 and F10) where Ca 2+ ions were cross-linked with the outer most alginate layer of the beads to yield a complex structure (12).…”

Section: Morphological Features Of the Prepared Beadsmentioning

confidence: 99%

“…First, when chitosan-alginate loaded beads were placed at a low pH (1.2), the negatively charged carboxylate groups of sodium alginate began to protonate to form uncharged -COOH groups. This reduced the degree of cross linking due to decreased electrostatic interactions among the alginate and chitosan chains within the beads, resulting in increasing fluids uptake and swelling of the beads (12). In addition, cefaclor as a small, hydrophilic molecules at pH 1.2 is highly ionized, resulting in an increase in drug solubility; hence it diffuses out easily.…”

Section: In Vitro Drug Releasementioning

confidence: 99%

Development of coated beads for oral controlled delivery of cefaclor: In vitro evaluation

Abdul¹,

Fahmy²

2013

Acta Pharmaceutica

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The aim of the present study was to develop and characterize coated chitosan-alginate beads containing cefaclor as a controlled release delivery system. Coated cefaclor beads were prepared by solvent evaporation techniques. Beads were found to be intact and spherical in shape. Their size range was 1.05 to 2.06. The loading efficiency showed maximum value when the concentration of cefaclor, chitosan and PEG 400 was 10 % (m/V), 0.5 % (m/V) and 2 % (V/V), respectively. Best retardation of cefaclor release from chitosan-alginate beads was achieved by coating with 15 % of shellac in formula F19. A significant antimicrobial activity (p < 0.05) against Staphylococcus aureus and Klebsiella pneumoniae was observed for formula F19 compared to the standard antibiotic disc. Furthermore, the simulated plasma profile showed the superiority of F19 in sustaining drug release for more than 12 h. Therefore, shellac coated chitosan-alginate beads could be considered a successful controlled release oral cefaclor dosage form.

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Investigation of water uptake behavior and stability of calcium alginate/chitosan bi-polymeric beads: Part-1

Cited by 105 publications

References 28 publications

Microparticulate polyelectrolyte complexes for gentamicin transport across intestinal epithelia

Microparticulate polyelectrolyte complexes for gentamicin transport across intestinal epithelia

Economically Viable Fungal Production by Using Alternative Plant Material for the Removal of Heavy Metal

Development of coated beads for oral controlled delivery of cefaclor: In vitro evaluation

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