Investigation of XRCC1 Arg399Gln, Arg280His, and Arg194Trp polymorphisms effects on the induction of micronucleus by Aflatoxin B1 in in vitro

Aydın, Muhsin; Arslan, Mehmet; Rencüzoğulları, Eyyüp; Gözaydın, Cengiz; Genç, Ahmet; Bayram, Süleyman

doi:10.1016/j.genrep.2017.08.002

Cited by 1 publication

(1 citation statement)

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“…When genotoxic studies are performed, application of in vivo tests is especially important because many mycotoxins may show genotoxic effects in in vivo or by being metabolized in the presence of metabolic activators in in vitro. These mycotoxins must undergo biotransformation processes in order to be able to show genotoxicity (Aydın et al, 2017;Bayram, Rencüzoğulları, Almas, & Genç, 2016;Flajs & Peraica, 2009;Yourtee & Kirk-Yourtee, 1986). Wehner, Marasas, & Thiel (1978a) found out that toxins such as austdiol, austocystins A and D, kojic acid, and viridicatum toxin had mutagenic effects after biotransformation.…”

Section: Discussionmentioning

confidence: 99%

Genotoxic and mutagenic effects of mycotoxins: a review

Aydın¹,

Rencüzoğulları²

2019

Commagene Journal of Biology

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In this article, genotoxic and mutagenic effects of mycotoxins that are produced by various fungus species have been reviewed. A total of 259 mycotoxins were found in the literature. Genotoxic effects of 109 of these were investigated. Among the studied mycotoxins, only actinomycin D, aflatoxin, alternariol, chrysazin (dantron), citrinin, fumonisin, mytomycin C, nivalenol, ochratoxin A, patulin, sterigmatocystin, versicolorin A and B, vomitoxin, and zearalenone have sufficient number of studies that present or prove their genotoxic effects. Additional studies are required in order to determine whether other mycotoxins have any genotoxic effects. The current study provides valuable information regarding studied mycotoxins. Therefore, it may lead researchers for designing future mycotoxin-related studies that have never been studied.

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