Investigation on Anti-Ulcer Activity of Rhododendron Arboreum Flower in Wistar Rat

When it comes to choosing which cosmetics to buy, consumers typically identify the smell as the factor that is most important to them. When uncovered, the fatty acids, oils, and surfactants that are frequently included in cosmetic formulations can all contribute to the production of odours that are unpleasant. Essential oils are used in a wide variety of cosmetic products because, in addition to the fragrant contributions they make, they serve as preservatives, active agents, and additions that are helpful to the skin. In addition, the growing demand for natural components has significantly contributed to the revival of interest in plant derivatives, particularly essential oils, in the industries of cosmetics and health. Popular cosmetic companies have been forced to promote natural fragrances and pick for minimally processed natural materials as a result of the potential health concerns related with artificial smell compounds, which are major components of cosmetics. As a result of this pressure, the cosmetic industry as a whole has moved towards natural fragrances. Some of the most highly regarded essential oils that are utilised in the creation of fragrances include citrus, lavender, eucalyptus, tea tree, and other flower oils. Some of the most highly prized scent components that are utilised in the creation of various cosmetics include linalool, geraniol, limonene, citronellol, and citral. In the fields of cosmetics and cosmeceuticals, essential oils have a wide variety of applications, including use as a source of natural fragrances. The purpose of this review was to shed light on those applications. Origins of essential oils, commercial viability of essential oils, chemical makeup of essential oils, fragrance classification, olfactory character of essential oils, authenticity, and safety will all receive the attention they deserve.

Section: Introductionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Role of Essential Oil Used Pharmaceutical Cosmetic Product

Sharma,

Kumar,

Mittal

et al. 2023

“…Therefore, GA treatment-induced AMPK activation may be responsible for the downregulation of insulin receptor substrate-1 Ser636/639, which suppresses gluconeogenesis [36], the upregulation of the SHP gene, which inhibits PEPCK and P6Pase [37], and the facilitation of transducer of regulated cAMP response element-binding protein-2, which inhibits PEPCK and G6Pase gene expression [38]. Indeed, we found that administering GA to mouse liver and hepatocytes led to an upregulation of Akt signalling [40]. Liver Akt activity is associated with maintaining normal blood sugar levels [41].…”

Section: Gallic Acidmentioning

confidence: 96%

Combine Therapy of Gallic Acid and Allicin in Management of Diabetes

Kumar¹,

Gardner-Sood²,

Rana³

et al. 2023

Type 2 diabetes, also known (DM) is a metabolic disorder with a high mortality and disability incidence. The development and activation of oxidative stress (OS) are crucial to the pathogenic development of DM. Pathophysiological evidence suggests that OS contributes to the onset and progression of DM through its association with hyperglycemia, resistance to insulin, and inflammation. It's worth noting that more and more studies are investigating the benefits of natural antioxidants for managing DM. Many different types of culinary and herbal plants contain the antioxidant and anti-inflammatory compounds gallic acid (GA) and allicin, respectively. The synthesis of advanced glycation end products (AGEs) is inhibited, fat is stored less, blood sugar and weight are improved, and the body produces fewer AGEs, according to the study's authors. Inhibition of RAGEs and prevention of AGE activity following treatment with GA and allicin resulted in reduced oxidative stress and enhanced insulin secretion. The goals of this article are to (1) provide evidence that GA and allicin may be effective antihyperglycemic treatments for DM and its complications and (2) provide a comprehensive review of the current state of knowledge regarding studies examining the role of oleic acid in this disease.

“…However, its presence in the brain is extremely scarce in comparison to that of CB1. Nevertheless, it appears that CB2 plays a significant part in the functions of macrophages and microglia [76,77]. When microglia are activated, there is a significant rise in the expression of CB2, and activation of CB2 leads to a reduction in the synthesis of chemicals that promote inflammation [78].…”

Section: Cannabinoids and Endocannabinoids Systemsmentioning

confidence: 99%

Role of Terpenoids Active Ingredients Targeting for Neuroprotective Agents

Kashyap,

Kumar,

Rana

et al. 2023

Neuroinflammation is a characteristic sign of a wide variety of neurodegenerative diseases, including Alzheimer's and Parkinson's, amongst others. Microglia, which are native immune cells found in the brain, become activated very quickly in response to a brain infection or injury. When microglia become overactivated, their production of pro-inflammatory and cytotoxic chemicals can become unregulated and uncontrolled, which is the primary cause of neuroinflammation. Microglia are principally responsible for neuroinflammation. As a result, the investigation of novel approaches to reduce neuroinflammatory reactions is an essential component of neurodegenerative disease treatment. In the research of brain inflammation, bacterial lipopolysaccharide is frequently used. This compound is responsible for the initiation of a number of significant cellular processes that significantly contribute to the pathophysiology of neuroinflammation.