Investigation on photopolymerization of PEGDA to fabricate high-aspect-ratio microneedles

Kim, Young Ho; Lee, Hyemin; Choi, Hyewon; Yoo, Kee-Youn; Yoon, Hyunsik

doi:10.1039/d2ra00189f

Cited by 17 publications

(6 citation statements)

References 29 publications

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“…However, the exposure time has a limitation. For example, in photopolymerization-based 3D printing, to ensure the accuracy of printed 3D objects, the exposure time of each layer is limited in the range from 2 to 8 s. Kim et al [51] studied the photopolymerization behavior of PEGDA under a photomask, showing that a long exposure time can cause pattern edges to grow and even connect discrete patterns into one piece. This phenomenon, which can be called the lateral diffusion effect, is believed to be mainly attributed to the light diffraction, scattering and straightness of the light source, especially on the substrate with a rough surface, whose phenomenon should be more obvious.…”

Section: Patterning Methodsmentioning

confidence: 99%

A facile method to pattern silver nanowires on sandpaper and its application in pressure sensors

Wang¹,

Geng²

2023

Flex. Print. Electron.

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A conductive layer deposited on a rough surface can effectively improve the performance of a pressure sensor; however, its further application requires patterning of the conductive layer to obtain the corresponding electrical layout. In this paper, a facile patterning method with few steps was proposed for patterning silver nanowires (AgNWs) on sandpaper. This method employed a photocurable resin as the key material to define the pattern using a photomask under UV exposure. It was found that greater cure depths and narrower light-transmitting areas require longer exposure times. A pattern with linewidth of approximately 40 μm was obtained on M-400 sandpaper (M-400 stands for the mesh number). Based on this method, pressure sensors consisting of interdigital electrodes with rough surfaces and sponge-sensing layers were fabricated. The best resulting sensor exhibited a high-pressure sensitivity of 21.89 kPa-11 for less than 2 kPa, a low detection limit (24.5 Pa), low operating voltage (0.01 V), and short response time (84 ms). Moreover, this patterning method has no special requirements for materials and substrates and thus can be applied to pattern other materials on rough or smooth surface substrates.

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Section: Patterning Methodsmentioning

confidence: 99%

A facile method to pattern silver nanowires on sandpaper and its application in pressure sensors

Wang¹,

Geng²

2023

Flex. Print. Electron.

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“…1 Schematic of the mechanism of action between MNs and skin. The preparation process of drug-loaded solid MNs with a two-step casting method [ 24 ], Copyright 2021 American Chemical Society; b droplet-born air-blowing method [ 25 ], Copyright 2021 Elsevier; and c free radical polymerization method [ 26 ], Copyright 2022 Royal Society of Chemistry …”

Section: Introductionmentioning

confidence: 99%

Microneedle-mediated treatment for superficial tumors by combining multiple strategies

Wang

et al. 2023

Drug Deliv. and Transl. Res.

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Superficial tumors are still challenging to overcome due to the high risk and toxicity of surgery and conventional chemotherapy. Microneedles (MNs) are widely used in the treatment of superficial skin tumors (SST) due to the high penetration rate of the stratum corneum (SC), excellent biocompatibility, simple preparation process, high patient compliance, and minimal invasion. Most importantly, MNs can provide not only efficient and rarely painful delivery carriers, but also combine multi-model strategies with photothermal therapy (PTT), immunotherapy, and gene therapy for synergistic efficacy. To promote an in-depth understanding of their superiorities, this paper systematically summarized the latest application progress of MNs in the treatment of SST by delivering various types of photosensitizers, immune signal molecules, genes, and chemotherapy drugs. Just as important, the advantages, limitations, and drug release mechanisms of MNs based on different materials are introduced in the paper. In addition, the application of MN technology to clinical practice is the ultimate goal of all the work. The obstacles and possible difficulties in expanding the production of MNs and achieving clinical transformation are briefly discussed in this paper. To be anticipated, our work will provide new insights into the precise and rarely painful treatment of SST in the future. Graphical Abstract

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“…Furthermore, compared to other PEGDA polymer that are liquid at room temperature and pressure, PEGDA700 has been shown to demonstrate the fastest polymerization rates. 48 The optimal parameters for (extrusion-based) 3D printing of the copolymer biomaterial were determined, as well as analysis of the printing fidelity and elucidation of the achievable range of mechanical and physical properties through tuning the POMaC/PEGDA ratio. The 3D printed copolymer biomaterials were determined to be biocompatible by a cell viability assay.…”

Section: Introductionmentioning

confidence: 99%

“…PEGDA700 was chosen as it is a liquid at room temperature and pressure, unlike commercially available PEGDA polymers with molecular weights ≥1000 Da which are solids. Furthermore, compared to other PEGDA polymer that are liquid at room temperature and pressure, PEGDA700 has been shown to demonstrate the fastest polymerization rates . The optimal parameters for (extrusion-based) 3D printing of the copolymer biomaterial were determined, as well as analysis of the printing fidelity and elucidation of the achievable range of mechanical and physical properties through tuning the POMaC/PEGDA ratio.…”

Section: Introductionmentioning

confidence: 99%

3D Printability Assessment of Poly(octamethylene maleate (anhydride) citrate) and Poly(ethylene glycol) Diacrylate Copolymers for Biomedical Applications

Wales

Keshavarz

Howe

et al. 2022

ACS Appl. Polym. Mater.

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Herein, we present the first example of 3D printing with poly(octamethylene maleate (anhydride) citrate) (POMaC), a bio-adhesive material which has shown particular promise for implantable biomedical devices. The current methods to fabricate such devices made from POMaC are hindered by the imposed constraints of designing complex molds. We demonstrate the feasibility of exploiting additive manufacturing to 3D print structural functional materials consisting of POMaC. We present 3D printing of biomaterial copolymers consisting of mixtures of poly(ethylene glycol) diacrylate (PEGDA) and POMaC at different ratios. The required parameters were optimized, and characterization of the printing fidelity and physical properties was performed. We have also demonstrated that a range of mechanical properties can be achieved by tuning the POMaC/PEGDA ratio. The biocompatibility of the copolymers was ascertained via a cell viability assay. Such tunable 3D printed biomaterials consisting of POMaC and PEGDA will have significant potential application in the development of functional biomaterial tissue scaffolds and biomedical devices for the future of personalized medicine.

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Investigation on photopolymerization of PEGDA to fabricate high-aspect-ratio microneedles

Abstract: Fabrication conditions for high-aspect-ratio MNs by the photopolymerization of PEGDA were investigated. The influence of prepolymer molecular weight and the degree of UV absorption by the photoinitiator (PI) were studied to optimize the conditions.

Cited by 17 publications

References 29 publications

A facile method to pattern silver nanowires on sandpaper and its application in pressure sensors

A facile method to pattern silver nanowires on sandpaper and its application in pressure sensors

Microneedle-mediated treatment for superficial tumors by combining multiple strategies

3D Printability Assessment of Poly(octamethylene maleate (anhydride) citrate) and Poly(ethylene glycol) Diacrylate Copolymers for Biomedical Applications

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