Investigation on Reference Intervals and Regional Differences of Platelet Indices in Healthy Chinese Han Adults

Jiang, Hong; Zhao, Min; Pan, Baishen; Zhang, Jie; Peng, Meng; Huang, Xianzhang; Hao, Xiaoke; Wang, Lanlan; Zhang, Xin; Wei, Guo; Qu, Rui; Chen, Wenxiang; Wu, Xinzhong; Ma, Yue; Shang, Hong

doi:10.1002/jcla.21721

Cited by 23 publications

(26 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our previous work [10], we observed an interesting phenomenon that the people in Southwest China of Chengdu plain had a lower mean value of PLT count and PCT but a higher MPV value than other populations. This was in agreement with the other observations that were made by other Chinese researchers [18][19][20][21]. In order to further explore this unique difference and to meet the special requirement for the Sichuan basin on other platelet indices, we performed a much more large-scale retrospective analysis on as many as 46872 local healthy individuals (the largest scale so far reported) aged >18 yrs, so as to exclude genetic and environmental factors, which were known to influence platelet indices.…”

Section: Discussionsupporting

confidence: 94%

“…However, when stratified by narrow age classes, we found there was a slight decline after 51 years old in both genders ( Figure 2C). Our results are quite agree with Jiang Hong's [19].…”

Section: Discussionsupporting

confidence: 90%

“…The ratio of MPV/ PLT increased with aging all the time (Figure 1, 2F). All of these results are also consistent with Jiang Hong's [19]. However, the reasons are still unknown, maybe it is related to hormone levels fluctuation.…”

Section: Discussionsupporting

confidence: 83%

“…Additionally, significant differences in platelet count have been repeatedly observed in different ethnic populations and mainly attributed to genetic factors [27], which, however, remain largely unknown. In particular, both the lower and the upper limits of the normal range seem to be inappropriate for the Chinese population, especially Southwest Chengdu people [10,[18][19][20][21] /L] (Data was released by Chinese Ministry of Health), which was consistent with the previous finding of Qian Niu [21]. This highlighted the necessity and importance of deriving new and region-specific reference ranges for PLT indices.…”

Section: Discussionsupporting

confidence: 77%

See 3 more Smart Citations

Large Population Study for Age- and Gender- Related Variations of Platelet Indices in Southwest China Healthy Adults

Yong¹

2015

HTIJ

View full text Add to dashboard Cite

Aim: The present data on the evaluation of platelet parameters in Chinese Han population are still limited. This study was to identify age-and sex-specific variations of platelet indices in Southwest China, including platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT) and platelet-large cell ratio (P-LCR), through a large-scale investigation of healthy people. Methods:We performed a retrospective analysis on 46872 local healthy individuals (men: n=26,582 and women n=20,290) aged >18yrs. All the subjects were healthy people through the health screening. PLT indices were measured with Sysmex XE-2100 blood cell automatic analyzer. Associations of platelet indices with dependent variables were investigated by ANOVA analysis. Correlation was assessed by the Pearson's correlation coefficient(r). Statistical analyses were performed with SPSS 20.0 software (Chicago, IL) and Excel 2007. Results:The distribution of platelet count and PCT by age and gender shows a slow, progressive decline with aging in both males and females. On average, a 10-year increase in age corresponds to an average of 6×10 9 /L decrease in platelet count, adjusting for gender (P<0.001). On the contrary, the distribution of MPV, PDW, P-LCR and MPV/PLT ratio by age and gender shows a slow, progressive increasing trend with aging in both genders. The age was negatively correlated with PLT (r=-0.23, P=0.000), PCT (r=-0.24, P=0.000). While age was positively correlated with either MPV (r=0.1, P=0.72), PDW (r=0.1, P=0.024), P-LCR (r=0.09, P=0.002), and MPV/PLT (r=0.21, P=0.001). A positive correlation between MPV and PDW, MPV and P-LCR, PDW and P-LCR was observed, while negative correlation between MPV and PLT, PDW and PLT, P-LCR and PLT was also presented. It's very interesting that mean PLT in Southwest China Chengdu region was lower than other countries while the MPV, PDW, P-LCR, MPV/PLT values in our study was found to be higher than all other results reported. All of the platelet indices except for MPV showed significantly different distributions from males to females. Conclusion:These findings suggest that the platelet indices could be greatly influenced in healthy subjects by age and sex. The lower platelet count accompanied with higher MPV, PDW and P-LCR, which were possibly the result of the adaption to the basin environment. Based on these findings, it would be reasonable to conduct formal prospective studies to determine the clinical significance. Further studies should be necessary to make additional verification. Unique reference ranges of some routine inspection items should also be established for people of different ethnic groups or in different regions. when analyzed along with the other PLT parameters, helps in the differential diagnosis of the thrombocytosis related diseases [4]. Recent studies have explored the role of plateletcrit (PCT) as independent risk factors of spontaneous echo contrast in patients with mitral stenosis [5]. Considering the role of the PLT indices in cl...

show abstract

Section: Discussionsupporting

confidence: 94%

“…However, when stratified by narrow age classes, we found there was a slight decline after 51 years old in both genders ( Figure 2C). Our results are quite agree with Jiang Hong's [19].…”

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 77%

See 2 more Smart Citations

Large Population Study for Age- and Gender- Related Variations of Platelet Indices in Southwest China Healthy Adults

Yong¹

2015

HTIJ

View full text Add to dashboard Cite

show abstract

“…In healthy individuals, MPV is inversely related to PLT, but is closely regulated to maintain total platelet mass constant [Adibi, Faghih Imani, Talaei, & Ghanei, ; Margetic, ]. Genetic and acquired factors such as race, age, smoking status, alcohol consumption, and physical activity change blood PLT and MPV [Hong et al, ; Lippi et al, ]. Our search through literature in the field did not yield any studies comparing PCT values of individuals with ASD and healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Platelet Parameters in Children with Autism Spectrum Disorder: Elongated Collagen‐Adenosine Diphosphate and Collagen‐Epinephrine Closure Times

et al. 2019

View full text Add to dashboard Cite

Changes related to the serotonin system play a key role in the etiology of autism spectrum disorder (ASD). Although we know that platelets are associated with the serotonin system, their relation to ASD has not yet been elucidated. In this study, we aim to investigate platelet parameters in children with ASD. Forty patients with ASD according to Diagnostic and Statistical Manual of Mental Disorders 5 (DSM‐5) and 30 healthy controls were included in the study. A complete blood count was done to measure parameters relating to platelet morphology. Moreover, prothrombin time (PT) and activated partial thromboplastin time (aPTT) were evaluated. Lastly, platelet functions were assessed with a platelet functions analyzer 100 (PFA‐100) device by measuring collagen‐ADP and collagen‐epinephrine (EPI) closure times. There was not a significant difference between the groups in terms of platelet count, mean platelet volume (MPV), platelet distribution width, plateletcrit, PT, or aPTT parameters for ASD patients when compared to the control group (P > 0.05). However, MPV in severe ASD, as quantified by the Childhood Autism Rating Scale, was found to be significantly lower when compared to mild to moderate ASD (P = 0.047). Moreover, in terms of platelet functions, the elongation in collagen‐ADP and collagen‐EPI closure times were significantly higher for the ASD group (P = 0.044). These results may suggest an impairment in platelet functions rather than in platelet morphology for children with ASD. Considering these results, further investigation of thrombocyte functions in the ASD may lead to a better understanding of the pathogenesis of ASD and to the development of our limited knowledge of this disorder. Autism Res 2019, 12: 1069–1076. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Serotonin is a chemical that is found in brain as wells as in blood cells that function in blood clotting in the human body. There are problems related to serotonin in brains of people who have autism. Thus, blood clotting cells may also be affected in people who have autism. In this study, we compare blood clotting functions of children with autism with that of healthy controls.

show abstract

Platelet Counting and Measurement of Platelet Dimensions

Noris

Zaninetti

2017

Platelets in Thrombotic and Non-Thrombotic Disorders

View full text Add to dashboard Cite

Investigation on Reference Intervals and Regional Differences of Platelet Indices in Healthy Chinese Han Adults

Cited by 23 publications

References 10 publications

Large Population Study for Age- and Gender- Related Variations of Platelet Indices in Southwest China Healthy Adults

Large Population Study for Age- and Gender- Related Variations of Platelet Indices in Southwest China Healthy Adults

Evaluation of Platelet Parameters in Children with Autism Spectrum Disorder: Elongated Collagen‐Adenosine Diphosphate and Collagen‐Epinephrine Closure Times

Platelet Counting and Measurement of Platelet Dimensions

Contact Info

Product

Resources

About