Investigation on risk of phthalate ester in drinking water and marketed foods

Yin, Maoyuan; Su, Kim Hyun

doi:10.38212/2224-6614.2976

Cited by 2 publications

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“…In the United Kingdom, DHEP and mono-2-ethylhexyl phthalate were detected in poultry [30]. Yin and Su [31] detected DOP in three samples of packaged pork and chicken in Taiwan. These apparent discrepancies are likely due to dissimilarities among the detection analyses.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Pollution of Phthalates in Pork and Chicken in Taiwan Using Liquid Chromatography–Tandem Mass Spectrometry and Assessment of Health Risk

Tsai

Chang

et al. 2019

Molecules

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Phthalates are widely used plasticizers that can cause endocrine disruption, mutagenicity, and carcinogenic effects and can contaminate food through various pathways. Investigations are scanty on phthalate pollution of livestock and poultry meat and their dietary exposure to humans. The present study assessed residual levels of phthalates in unpackaged pork (30 samples) and unpackaged chicken (30 samples) and their relevance to meat consumption and health risks in the Taiwanese population. Phthalate quantity was assessed by liquid chromatography–tandem mass spectrometry; the materials included diisononyl phthalate, diisodecyl phthalate, benzyl butyl phthalate, di-2-ethylhexyl phthalate (DEHP), and di-n-butyl phthalate. The Taiwan Food and Drug Administration (TFDA) has established values of tolerable daily intake (TDI) for the five phthalates. The major compound detected was DEHP, which ranged from 0.62 to 0.80 mg/kg in two pork samples, and 0.42–0.45 mg/kg in three chicken samples. Collectively, 8.33% of the phthalate-residue-containing samples tested positive for DEHP. The concentrations of DEHP were lower than the screening value of 1.0 mg/kg, as defined by the TFDA. Health risk was calculated as the estimated daily intake (DI) for any likely adverse effects; the DI of DEHP residues was <1% of the TDI value. The estimated risk was insignificant and considered to be safe, indicating that there is no risk to the health of Taiwanese population due to meat consumption. However, it is suggested that a phthalate monitoring program in meat should be instituted for any possible effects in future on human health.

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Section: Discussionmentioning

confidence: 99%

Analysis of Pollution of Phthalates in Pork and Chicken in Taiwan Using Liquid Chromatography–Tandem Mass Spectrometry and Assessment of Health Risk

Tsai

Chang

et al. 2019

Molecules

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Development of Ecotoxicogenomic Biomarkers on the Freshwater Shrimp (Neocaridina denticulate) Following Short-Term Exposure to Dipropyl Phthalate

蔡¹

2013

IJE

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Phthalate esters (PAEs), which are widely used in industrial chemicals that serve as important additives to impart flexibility to polyvinyl chloride resins and have become widely diffused in the environment, are considered to be endocrine disrupting chemicals (EDCs). In order to assess the toxicity of PAE to aquatic crustacean, after shrimps (Neocaridina denticulate) were short-term exposed to a sublethal concentration (50 mg/L) of dipropyl phthalate (DPrP), the differential expression genes were isolated and identified using suppression subtractive hybridization (SSH) on the samples prepared from the whole individual. There were 71 unique expressed sequence tags (ESTs) which were identified by homology with data-based sequences, including 23 ESTs corresponded to known genes and 48 ESTs with unknown function. The known genes could be divided into nine classes on the basis of physiological function: genes related to ribosomal, metabolism, immune and structural molecules, concerning the translation-related molecules, involved respiration and signaling, and responding to signaling and vision. By comparing the level of gene transcription in DPrP-treated group vs. non-treated group using semi-quantitative RT-PCR, we found that six of twelve selected genes were significantly up-regulated following exposure to DPrP at high concentration (50 mg/L), including two immune-related genes, one metabolism-related gene and 3 unknown genes. There were eight genes which are significantly responding to DPrP treatment at 1.0 mg/L, including five up-regulated genes (four known genes and one unknown gene) and three down-regulated unknown genes. After exposure to 0.5 mg/L of DPrP, only four genes (three known genes and one unknown gene) were affected and their mRNA levels increased significantly. These results suggest that N. denticulate may be harmed via the change of the globally physiological function following exposure in non-lethal PAE-polluted aquatic environment; in addition, the ESTs derived from N. denticulate can be used for studying the ecotoxicological effect of other pollutants in the aquatic environment.

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Investigation on risk of phthalate ester in drinking water and marketed foods

Cited by 2 publications

References 0 publications

Analysis of Pollution of Phthalates in Pork and Chicken in Taiwan Using Liquid Chromatography–Tandem Mass Spectrometry and Assessment of Health Risk

Analysis of Pollution of Phthalates in Pork and Chicken in Taiwan Using Liquid Chromatography–Tandem Mass Spectrometry and Assessment of Health Risk

Development of Ecotoxicogenomic Biomarkers on the Freshwater Shrimp (Neocaridina denticulate) Following Short-Term Exposure to Dipropyl Phthalate

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