Investigation on Serum Hormonal Parameters (Ghrelin, Corticosterone, Insulin, T3 and T4) in Chronic Mild Stress Rat Model of Depression

Narimani-Rad, Mohammad; Babapour, Vahab; Zendehdel, Morteza; Abbasi, Mehran Mesgari; Farhang, Sara

doi:10.9775/kvfd.2013.9976

Cited by 2 publications

(1 citation statement)

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“…T4 has been reported to social behaviour rats [ 21 ] and social stress can even induce hypothyroidism in intruders [ 39 ]. Moreover, hypothyroidism is strongly associated with emotional behaviour and depression [ 40 ] and with reduced exploratory behavior and hypoactivity [ 41 – 44 ], although the results are not always consistent [ 23 , 45 – 47 ]. In dogs, low TH levels have been shown to be associated with owner-directed aggression, where TH replacement is suggested as a possible therapy [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of a Mutation in the Thyroid Stimulating Hormone Receptor (TSHR) on Development, Behaviour and TH Levels in Domesticated Chickens

et al. 2015

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The thyroid stimulating hormone receptor (TSHR) has been suggested to be a “domestication locus” in the chicken, due to a strong selective sweep over the gene found in domesticated chickens, differentiating them from their wild ancestor the Red Junglefowl (RJF). We investigated the effect of the mutation on development (incubation time), behaviour and thyroid hormone levels in intercross chickens homozygous for the mutation (d/d), wild type homozygotes (w/w) or heterozygotes (d/w). This allowed an assessment of the effect of genotype at this locus against a random mix of RJF and WL genotypes throughout the rest of the genome, controlling for family effects. The d/d genotype showed a longer incubation time, less fearful behaviours, lower number of aggressive behaviours and decreased levels of the thyroid hormone T4, in comparison to the w/w genotype. The difference between TSHR genotypes (d/d vs. w/w) in these respects mirrors the differences in development and behaviour between pure domesticated White Leghorns and pure RJF chickens. Higher individual T3 and T4 levels were associated with more aggression. Our study indicates that the TSHR mutation affects typical domestication traits, possibly through modifying plasma levels of thyroid hormones, and may therefore have been important during the evolution of the domestic chicken.

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