Investigation on sleep and mental health of patients with Parkinson's disease during the Coronavirus disease 2019 pandemic

Xia, Yun; Kou, Liang; Zhang, Guoxin; Han, Chao; Hu, Junjie; Wan, Fang; Yin, Sijia; Sun, Yi‐Feng; Wu, Jiawei; Li, Yunna; Zhang, Zhentao; Huang, Jinsha; Xiong, Nian; Wang, Tao

doi:10.1016/j.sleep.2020.09.011

Cited by 41 publications

(96 citation statements)

References 31 publications

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“…In addition, we showed that a male sex was associated with clinical anxiety, while a female sex was reported to be a potential risk factor for anxiety both in general population and in PD patients [ 26 , 27 ]. In the previous report, Xia et al showed lower scores of depression and anxiety in male PD patient than female, though it was not multivariate analysis [ 10 ]. In addition, we are currently under the distinct stress due to COVID-19 pandemic that did not exist in the past, so we need more cases to determine the impact of sex on the neuropsychiatric symptoms under COVID-19 pandemic.…”

Section: Discussionmentioning

confidence: 99%

“…No minors were among the participants. According to a priori power analysis (with 95% power and 5% type I error rate) of the results of previous studies [ 8 – 10 ], the minimum number for the sample was found to be 41 patients for the comparative study of the prevalence of psychiatric symptoms during COVID-19 pandemic in PD and control groups. This study was a cross-sectional, single hospital-based survey conducted from April 22, 2020 to May 15, 2020.…”

Section: Methodsmentioning

confidence: 99%

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Risk factors for neuropsychiatric symptoms in patients with Parkinson’s disease during COVID-19 pandemic in Japan

et al. 2021

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The worsening of neuropsychiatric symptoms such as depression, anxiety, and insomnia in patients with Parkinson’s disease (PD) has been a concern during the COVID-19 pandemic, because most people worked in self-isolation for fear of infection. We aimed to clarify the impact of social restrictions imposed due to the COVID-19 pandemic on neuropsychiatric symptoms in PD patients and to identify risk factors associated with these symptoms. A cross-sectional, hospital-based survey was conducted from April 22, 2020 to May 15, 2020. PD patients and their family members were asked to complete paper-based questionnaires about neuropsychiatric symptoms by mail. PD patients were evaluated for motor symptoms using MDS-UPDRS part 2 by telephone interview. A total of 71 responders (39 PD patients and 32 controls) completed the study. Although there was no difference in the age distribution, the rate of females was significantly lower in PD patients (35%) than controls (84%) (P < 0.001). Participants with clinical depression (PHQ-9 score ≥ 10) were more common in PD patients (39%) than controls (6%) (P = 0.002). Multivariate logistic regression analysis revealed that an MDS-UPDRS part 2 score was correlated with the presence of clinical depression (PHQ-9 score ≥ 10) and clinical anxiety (GAD-7 score ≥ 7) (clinical depression: OR, 1.31; 95% CI, 1.04–1.66; P = 0.025; clinical anxiety: OR, 1.36; 95% CI, 1.07–1.72; P = 0.013). In the presence of social restrictions, more attention needs to be paid to the neuropsychiatric complications of PD patients, especially those with more severe motor symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Risk factors for neuropsychiatric symptoms in patients with Parkinson’s disease during COVID-19 pandemic in Japan

et al. 2021

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“…Our data confirm the findings of other studies that investigated the psychological impact of COVID-19 on PD patients, highlighting significant emotional sequelae of the pandemic. In particular, depression was previously reported to occur in 21% of patients, and anxiety in a percentage ranging from 21 to 81.7% of patients [ 17 ] and in 57.9% of caregivers [ 5 ]. In addition, increased distress was reported in 43.8% of patients and 53.1% of caregivers [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Anxiety, depression, and worries in advanced Parkinson disease during COVID-19 pandemic

et al. 2021

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Background The psychological impact of the COVID-19 outbreak and lockdown on frail populations with advanced Parkinson disease (APD) and their caregivers may present with peculiar features and require specific interventions. Methods We enrolled here 100 APD patients and 60 caregivers. Seventy-four patients were treated with device-aided therapies (DAT) and 26 with standard medical treatment (SMT). Through a telephonic interview, subjects underwent the Hospital Anxiety and Depression Scale (HADS-A; HADS-D), and an ad hoc questionnaire to explore thoughts and emotions related to the pandemic. Results Depression was observed in 35% of APD patients and anxiety in 39%, with a significant reduction of the latter after the lockdown (p= 0.023). We found a significant correlation between the type of therapy and the HADS-A score (p= 0.004). Patients’ main worries were as follows: a possible higher risk of COVID-19 infection (25%), interruption of non-pharmacological treatments (35%), interruption of outpatient clinics (38%), PD complications related to COVID-19 (47%). Patients treated with DAT manifested worries about device-related issues and risk for caregivers’ infection. The 40% of caregivers showed anxiety, while the 21.7% of them showed depression. Conclusion Our study reveals a higher prevalence of anxiety and the presence of peculiar worries and needs in APD patients during the pandemic alongside psychological sequelae of their caregivers. These findings are important for neurologists and healthcare services to foster strategies for the management of psychological distress in both patients and caregivers.

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“…A recent study by Xia et al investigated how the pandemic has affected sleep and mental health of patients with PD in comparison to healthy controls. 43 Results of their study showed that 68.9% of the PD patients suffered from sleep disturbance, a much higher rate than that of the general population. Further evidence shows that scores from the Hamilton Anxiety and Depression Scale on PD patients with sleep disturbances were significantly higher than PD patients who did not experience sleep disturbances, indicating that anxiety and depression are important factors affecting PD patients' sleep quality during the pandemic.…”

Section: Nonmotor Symptomsmentioning

confidence: 98%

“…Further evidence shows that scores from the Hamilton Anxiety and Depression Scale on PD patients with sleep disturbances were significantly higher than PD patients who did not experience sleep disturbances, indicating that anxiety and depression are important factors affecting PD patients' sleep quality during the pandemic. 43…”

Section: Nonmotor Symptomsmentioning

confidence: 99%

Effects of the COVID-19 Pandemic on Parkinson’s Disease: a Single-Centered Qualitative Study

Anghelescu

Bruno

Martino

et al. 2021

Can. J. Neurol. Sci.

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Background: The public health measure restrictions across the world due to COVID-19 have inadvertently impacted the routines for people with Parkinson’s disease (PD) and their care partners not only in terms of compromised neurological clinical care but also drastically changing the way of life to minimize the risk of becoming infected. This study explores initial PD patients’ lived experiences to observe how quality of life and health care has been affected at the start of the COVID-19 pandemic and provide insight into the importance of patient engagement and virtual care. Methods: Twenty-two virtual, in-depth semi-structured interviews with persons diagnosed with PD who usually attend a Movement Disorders specialty clinic in Calgary, Alberta, were completed between April 28 and May 13, 2020, and the care partners that wished to participate. Interviews were recorded and transcribed, after which transcripts were analyzed and coded into relevant themes using NVivo 12. Results: Impacts from the public health measures and COVID-19 results into three main themes: (1) Impacts of COVID-19 on PD Clinical Care; (2) Activities of Daily Living; (3) Attitudes and Perceptions. Participants reported worsening in motor and nonmotor symptoms and had to accommodate to clinical care via virtual means which were associated with limitations and suggestions for improvement of remote care. Conclusion: This study provides a unique opportunity for researchers to better understand the lived experiences of PD patients in all aspects of their life suggesting that innovative means are needed for facilitating virtual health care medicine and increased social interaction.

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Investigation on sleep and mental health of patients with Parkinson's disease during the Coronavirus disease 2019 pandemic

Cited by 41 publications

References 31 publications

Risk factors for neuropsychiatric symptoms in patients with Parkinson’s disease during COVID-19 pandemic in Japan

Risk factors for neuropsychiatric symptoms in patients with Parkinson’s disease during COVID-19 pandemic in Japan

Anxiety, depression, and worries in advanced Parkinson disease during COVID-19 pandemic

Effects of the COVID-19 Pandemic on Parkinson’s Disease: a Single-Centered Qualitative Study

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