Investigation on suitability of poly(urethaneimides) as biomaterials

Abstract

SYNOPSISThe mechanical properties of poly(urethaneimides) (PUI) were compared with known biomedical polyurethanes. The resistance of PUI to extraction with hexane and water and to sterilization with ethylene oxide or water vapor was stated. Water sorption and the permeability of water vapor, oxygen, and carbon dioxide through PUI foils were investigated. In blood compatibility, the PUI foils were similar to cellulose material Cuprophane, used in dialysis. Preliminary in uiuo testing of PUI implanted in rats indicated good biocompatibility of this polymer. 0 1995 John Wiley & Sons, Inc. I NTRODU CTI ONAmong all polymer materials used in medicine for implants, polyurethanes ( P U ) were found to be the materials causing the coagulation of thrombocytes and formation of blood clots in the smallest degree. To improve their hemocompatibility, the surface of polyurethane products was modified by applying hydrophilic poly ( ethyleneoxide ) , sometimes bound to heparin, a natural mucopolysaccharide, which is an agent counteracting coagulation of blood.' The biolization method was also used, based on seeding on the polyurethane surface a layer of antithrombogenic endothelium cells containing the hormone prostaglandin, which has an inhibiting effect on the process of thrombocyte aggregation. The prostaglandine BW 245C analog also exhibited such an effect. ' Another method of polymer hemotolerance improvement is the modification of their surface by introducing hydrophilic poly ( N-vinylpyrolidone ) , used, e.g., in the case of p~lymethylmethacrylate~ and polysiloxane implant^.^ In view of the occurrence of the cyclic imide sys-

Thermally stable poly(urethane‐imide)s with enhanced hydrophilicity for waterproof‐breathable textile coatings

“…Sang et al reviewed the various synthetic methods used to prepare poly(urethane‐imide)s 31 . In fact, poly(urethane‐imide)s have been explored for different applications such as biomaterials, 32 optical materials, 33 light‐emitting materials, 34 UV‐shielding materials 29,35 gas sensing, 36 and so forth.…”