Mining causes damage to the soil and rock mass, while rainfall has a pivotal impact on the mining slope stability, even leading to geological hazards such as landslides. Therefore, the study evaluated the mine landslide stability and determined the effectiveness of the treatment measures under the impact of pore water pressure changes caused by rainfall, taking the Kong Mountain landslide in Nanjing, Jiangsu Province, China, as the research object. The geological conditions and deformation characteristics were clarified, and the failure mechanism and influencing factors were analyzed. Also, the landslide stability was comprehensively evaluated and calculated utilizing the finite element-improved limit equilibrium method and FLAC 3D 6.0, which simulated the distribution of pore water pressure, displacement, etc., to analyze the influence of rainfall conditions and reinforcement effects. The results indicated the following: (1) Rainfall is the key influencing factor of the landslide stability, which caused the pore water pressure changes and the loosening of the soil due to the strong permeability; (2) The distribution of the pore water pressure and plastic zone showed that, during the rainfall process, a large area of transient saturation zone appeared at the leading edge, affecting the stability of the whole landslide and led to the further deformation; (3) After the application of treatment measures (anti-sliding piles and anchor cables), the landslide stability increased under both natural and rainfall conditions (from 1.02 and 0.94 to 1.38 and 1.31, respectively), along with a reduction in displacement, plastic zones, etc. The Kong Mountain landslide, with the implemented treatment measures, is in good stability, which is in line with the evaluation and calculation results. The study provides certain contributions to the stability evaluation and treatment selection of similar engineering under rainfall infiltration.