Through the reconstructed kernel particle method (RKPM), the dynamic buckling characteristics of submarine pressure hull under hydrostatic pressure and impact load is investigated in this study. First, a large deformation buckling calculation model for stiffened shell structures was established using RKPM and elastic–plastic constitutive models. To study the influence of load asymmetry on the buckling strength of the structure and provide fundamental technical support for submarine structural design, the dynamic buckling phenomenon of the structure was studied under three conditions: hydrostatic pressure acting alone, hydrostatic pressure and impact load acting simultaneously, and hydrostatic pressure and uniformly distributed impact load acting simultaneously. The starting time of buckling was used as the criterion for determining the critical load of dynamic buckling. The results indicate that under the combined action of static and dynamic loads, asymmetric dynamic loads can seriously affect the buckling strength of the structure.