2021
DOI: 10.1016/j.molliq.2020.114900
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Investigation on the impact of solvent on the photochemical properties of the photoactive anticancer drug Vemurafenib: A computational study

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Cited by 8 publications
(3 citation statements)
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“…It contains an eight-membered ring boronic ester pro-drug. In vitro, in silico and in cellulo, it showed low nanomolar activities that were very similar to the two FDA-approved drugs 70 . In vivo assays on TNBC on mice, it revealed great results for tumour necrosis 71 .…”
Section: Other Anticancer Boron-containing Drugs Discoverymentioning
confidence: 73%
“…It contains an eight-membered ring boronic ester pro-drug. In vitro, in silico and in cellulo, it showed low nanomolar activities that were very similar to the two FDA-approved drugs 70 . In vivo assays on TNBC on mice, it revealed great results for tumour necrosis 71 .…”
Section: Other Anticancer Boron-containing Drugs Discoverymentioning
confidence: 73%
“…Solvents and medium can have a profound effect on physical and chemical phenomena, including chemical reactions, and are crucial when investigating the mechanisms of different processes [ [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] ]. Hydrogen bonding is an important aspect of solvent effects in photochemical reactions [ [27] , [28] , [29] , [30] ].…”
Section: Introductionmentioning
confidence: 99%
“…Despite the growing interest in understanding drug-carrier interactions at a molecular level, prediction of the drug release kinetics remains challenging due to many interrelated physicochemical processes that occur simultaneously in the aqueous environment [14,15]. Therefore, studies on the interaction of active substances (drugs) and their carriers in hydrous medium are important as they provide the basic foundation for their application [16][17][18][19][20]. The influence of hydrogen bond interactions on the drug release kinetics need to be determined in order to understand the fundamental mechanisms governing the release process [21,22].…”
Section: Introductionmentioning
confidence: 99%