Investigation on the interaction between a heterocyclic aminal derivative, SBDC, and human serum albumin

Zhou, Qiuju; Xiang, Junfeng; Tang, Yalin; Liao, Jiangpeng; Yu, Chu‐Yi; Zhang, Hong; Li, Lin; Yang, Yueyang; Xu, Guangzhi

doi:10.1016/j.colsurfb.2007.07.007

Cited by 50 publications

(13 citation statements)

References 29 publications

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“…For static quenching, the relationship between fluorescence quenching intensity and the concentration of quenchers can be described by the binding constant formula [23]:…”

Section: Determinations Of Binding Constants and The Number Of Bindinmentioning

confidence: 99%

Investigation of the mechanism of binding of thiacloprid to human serum albumin using spectroscopic techniques and molecular modeling methods

et al. 2011

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Abstract. Fluorescence spectroscopy, UV absorption, circular dichroism (CD) spectroscopy and molecular modeling methods were used to characterize the binding properties of thiacloprid (TL) with human serum albumin (HSA) at molecular level under physiological conditions. The fluorescence intensity of HSA decreased regularly with the gradually increasing concentration of thiacloprid. The binding constant K at three different temperatures (290, 300 and 310 K) were 3.07, 2.74 and 1.35 × 10 4 M −1 , respectively, for TL-HSA interaction have been calculated from the relevant fluorescence data. CD spectroscopic measurements have shown that the secondary structures of the protein have been changed by the interaction of thiacloprid with HSA. Furthermore, the study of molecular modeling indicated that thiacloprid could be located on the surface of the binding pocket of subdomains IIA in HSA. The hydrophobic interaction was the major acting force and there are H-bonds and electrostatic interactions between TL and HSA, which is in good agreement with the results from the experimental thermodynamic parameters (the enthalpy change ΔH 0 and the entropy change ΔS 0 were calculated to be −20.378 kJ/mol and 16.328 J/mol K according to the Van't Hoff equation).

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“…For static quenching, the relationship between fluorescence quenching intensity and the concentration of quenchers can be described by the binding constant formula [23]:…”

Section: Determinations Of Binding Constants and The Number Of Bindinmentioning

confidence: 99%

Investigation of the mechanism of binding of thiacloprid to human serum albumin using spectroscopic techniques and molecular modeling methods

et al. 2011

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“…In order to confirm the quenching mechanism, fluorescence quenching data for EMPD-HSA system were analyzed according to the well-known Stern-Volmer equation [14,28] …”

Section: Fluorescence Quenching Mechanism and Binding Constantmentioning

confidence: 99%

Exploring the binding mechanism of dihydropyrimidinones to human serum albumin: Spectroscopic and molecular modeling techniques

Wang

et al. 2011

Colloids and Surfaces B: Biointerfaces

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“…[15][16][17][18] In this paper, we propose a potential targeting drug delivery system of MTO, targeted by folate and transported by HSA.…”

Section: Introductionmentioning

confidence: 99%

Investigation on a Potential Targeting Drug Delivery System Consisting of Folate, Mitoxantrone and Human Serum Albumin

Zhou

Xiang

et al. 2008

Chin. J. Chem.

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A potential targeting drug delivery system consisting of folate (FA), the targeting molecule, human serum albumin (HSA), the carrier, and mitoxantrone (MTO), the medicine, has been designed. Data obtained by UV absorption, fluorescence, and NMR techniques indicated the formation of ternary complexes and possible application to building a targeting drug delivery system by using FA, MTO and HSA. Furthermore, cytotoxicity assay indicated that the toxicity of the FA-HSA-MTO against PC-3 cell line was 79.95%, which was much higher than that of free MTO tested in totally the same conditions. About 30% increase of the toxicity should be owed to the targeting effect of FA. Thus, the feasibility and validity of a novel targeting drug delivery system, FA-HSA-MTO, was confirmed.

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Investigation on the interaction between a heterocyclic aminal derivative, SBDC, and human serum albumin

Cited by 50 publications

References 29 publications

Investigation of the mechanism of binding of thiacloprid to human serum albumin using spectroscopic techniques and molecular modeling methods

Investigation of the mechanism of binding of thiacloprid to human serum albumin using spectroscopic techniques and molecular modeling methods

Exploring the binding mechanism of dihydropyrimidinones to human serum albumin: Spectroscopic and molecular modeling techniques

Investigation on a Potential Targeting Drug Delivery System Consisting of Folate, Mitoxantrone and Human Serum Albumin

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