Investigation on the relationship between diabetes mellitus type 2 and cognitive impairment

Ebady, S.A.; Arami, Mohammad Ali; Shafigh, Mohammad Hadi

doi:10.1016/j.diabres.2008.08.020

Cited by 66 publications

(46 citation statements)

References 15 publications

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“…After controlling for the instant PG level, we found that T2DM patients with higher HbA 1c level had larger task-related BOLD responses in the ACC and bilateral DLPFC. Previous epidemiological studies showed that higher HbA 1c was associated with lower cognitive function [48, 49] in T2DM patients. Particularly in middle-aged T2DM patients, HbA 1c was negatively correlated with psychomotor efficiency [6] and inhibitory control ability [50], which are dominantly related to the function of DLPFC and ACC [51, 52].…”

Section: Discussionmentioning

confidence: 99%

Hyperactivation of working memory-related brain circuits in newly diagnosed middle-aged type 2 diabetics

Wang

Zhu

et al. 2014

Acta Diabetol

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Type 2 diabetes mellitus (T2DM) is well known for its adverse impacts on brain and cognition, which lead to multidimensional cognitive deficits and wildly-spread cerebral structure abnormalities. However, existing literatures are mainly focused on patients with advanced age or extended T2DM duration. Therefore, it remains unclear whether and how brain function would be affected at the initial onset stage of T2DM in relatively younger population. In current study, twelve newly-diagnosed middle-aged T2DM patients with no previous diabetic treatment history and twelve matched controls were recruited. Brain activations during a working memory task, the digit n-back paradigm (0-, 1- and 2-back), were obtained with functional magnetic resonance imaging (fMRI) and tested by repeated measures ANOVA. Whereas patients performed the n-back task comparably well as controls, significant load-by-group interactions of brain activation were found in the right dorsolateral prefrontal cortex (DLPFC), left middle/inferior frontal gyrus, and left parietal cortex, where patients exhibited hyperactivation in the 2-back but not the 0-back or 1-back condition compared to controls. Furthermore, the severity of chronic hyperglycemia, estimated by glycosylated hemoglobin (HbA1c) level, was entered into partial correlational analyses with task-related brain activations, while controlling for the real-time influence of glucose, estimated by instant plasma glucose level measured before scanning. Significant positive correlations were found between HbA1c and brain activations in the anterior cingulate cortex and bilateral DLPFC only in patients. Taken together, these findings suggest there might be a compensatory mechanism due to brain inefficiency related to chronic hyperglycemia at the initial onset stage of T2DM.

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Section: Discussionmentioning

confidence: 99%

Hyperactivation of working memory-related brain circuits in newly diagnosed middle-aged type 2 diabetics

Wang

Zhu

et al. 2014

Acta Diabetol

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“…In addition, some cross-sectional studies [14,15] lend support to the contention that CI may correlate with worse glycemic control. However, no significant correlation was observed between the fasting blood glucose or HbA1c levels, and performance on MMSE in the present study.…”

Section: Fig 1 Survey Procedures and Final Diagnosismentioning

confidence: 94%

Clinical backgrounds and morbidity of cognitive impairment in elderly diabetic patients

et al. 2011

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“…[66] In one study, the relationship between T2D and cognitive impairment had been evaluated and the subjects with diabetes had lower MMSE score than those without diabetes (P < 0.01). [67] Diabetes was also associated with increased odds of cognitive decline as determined by MMSE scores [odds ratio (OR), 1.9; 95%CI: 1.01-3.6]. Also, a statistically significant correlation between the duration of the disease and cognitive dysfunction was observed (P = 0.001).…”

Section: Association Between Diabetes and Cognitive Declinementioning

confidence: 78%

A Review on Type 2 Diabetes Mellitus Associated With Cognitive Disfunction and Dementia and Future Perspective

Sreedevi¹

2017

WJPPS

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Type 2 diabetes has previously been established as an independent risk for the development of both cognitive impairment and dementia. In their study, published in Neurology, the researchers wanted to investigate how inflammation, blood flow regulation in the brain and cognitive decline were related in people with the metabolic disorder.Diabetes mellitus affects millions of people, causing many complications. Recent studies have shown a link between diabetes and mild cognitive impairment (CI) in persons with earlier onset and greater severity of diabetes. Although the pathophysiology of CI is multifactorial, there is stronger evidence that lack of glycemic control resulting in hypo or hyperglycemia leads to CI among diabetic patients. With a growing geriatric population and increasing obesity trends in India, the prevalence of diabetes and the related CI, caregiving could be a challenge. Understanding the predisposing factors and the link between diabetes and CI or dementia can help improve the quality of life of diabetic individuals.

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Investigation on the relationship between diabetes mellitus type 2 and cognitive impairment

Cited by 66 publications

References 15 publications

Hyperactivation of working memory-related brain circuits in newly diagnosed middle-aged type 2 diabetics

Hyperactivation of working memory-related brain circuits in newly diagnosed middle-aged type 2 diabetics

Clinical backgrounds and morbidity of cognitive impairment in elderly diabetic patients

A Review on Type 2 Diabetes Mellitus Associated With Cognitive Disfunction and Dementia and Future Perspective

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