Investigation on the temperature distribution of integrated heater configurations in a Lab-on-a-Chip system

Streit, Petra; Nestler, J.; Schulze, Robert; Shaporin, Alexey; Otto, Thomas

doi:10.1109/eurosime.2017.7926229

Cited by 3 publications

(5 citation statements)

References 5 publications

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“…Consecutively, the influence of design parameters of the PCB on the thermal and electrical behaviour of the NTCs are evaluated in [18]. This publication is an extension describing the relation between the temperatures at the heaters and the biosensor together with the control in the relevant temperature range.…”

Section: Journal Of Micromechanics and Microengineeringmentioning

confidence: 99%

“…Vice versa the mean temperature T of a NTC is calculated by the inverse Steinhart-Hart equation ( 2) with the constants A T , B T , C T and D T [19][20][21]. The Steinhart-Hart parameters for the used NTCs are extracted from data-sheet and summarized in table 1 with R 0 = 4.7 kΩ and T 0 = 298.15 K. Reprinted, with permission, from [18].…”

Section: Heating Functionalitymentioning

confidence: 99%

“…© [2017] IEEE. Reprinted, with permission, from [18]. (a) and levels (b) (measures in mm, illustration not to scale).…”

Section: Heating Functionalitymentioning

confidence: 99%

See 2 more Smart Citations

Design methodology and results evaluation of a heating functionality in modular lab-on-chip systems

Streit¹,

Nestler²,

Shaporin³

et al. 2018

J. Micromech. Microeng.

Self Cite

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Lab-on-a-chip (LoC) systems offer the opportunity of fast and customized biological analyses executed at the ‘point-of-need’ without expensive lab equipment. Some biological processes need a temperature treatment. Therefore, it is important to ensure a defined and stable temperature distribution in the biosensor area. An integrated heating functionality is realized with discrete resistive heating elements including temperature measurement. The focus of this contribution is a design methodology and evaluation technique of the temperature distribution in the biosensor area with regard to the thermal-electrical behaviour of the heat sources. Furthermore, a sophisticated control of the biosensor temperature is proposed. A finite element (FE) model with one and more integrated heat sources in a polymer-based LoC system is used to investigate the impact of the number and arrangement of heating elements on the temperature distribution around the heating elements and in the biosensor area. Based on this model, various LOC systems are designed and fabricated. Electrical characterization of the heat sources and independent temperature measurements with infrared technique are performed to verify the model parameters and prove the simulation approach. The FE model and the proposed methodology is the foundation for optimization and evaluation of new designs with regard to temperature requirements of the biosensor. Furthermore, a linear dependency of the heater temperature on the electric current is demonstrated in the targeted temperature range of 20 °C to 70 °C enabling the usage of the heating functionality for biological reactions requiring a steady-state temperature up to 70 °C. The correlation between heater and biosensor area temperature is derived for a direct control through the heating current.

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Section: Journal Of Micromechanics and Microengineeringmentioning

confidence: 99%

Section: Heating Functionalitymentioning

confidence: 99%

See 1 more Smart Citation

Design methodology and results evaluation of a heating functionality in modular lab-on-chip systems

Streit¹,

Nestler²,

Shaporin³

et al. 2018

J. Micromech. Microeng.

Self Cite

View full text Add to dashboard Cite

show abstract

“…In many different situations, it is necessary to heat up a certain element or area to achieve the expected performance or a correct response. For example, the vast majority of biosensors require a specific temperature to operate [1]: bacteria indicators need a constant temperature in order to allow the bacteria to grow [2], or many gas sensors work at high temperatures to achieve a high selectivity and sensitivity [3,4]. For this reason, it is desirable to design small and low-cost heating elements.…”

Section: Introductionmentioning

confidence: 99%

Printed and Flexible Microheaters Based on Carbon Nanotubes

et al. 2020

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This work demonstrates a cost-effective manufacturing method of flexible and fully printed microheaters, using carbon nanotubes (CNTs) as the heating element. Two different structures with different number of CNT layers have been characterized in detail. The benchmarking has been carried out in terms of maximum operating temperature, as well as nominal resistance and input power for different applied voltages. Their performances have been compared with previous reports for similar devices, fabricated with other technologies. The results have shown that the heaters presented can achieve high temperatures in a small area at lower voltages and lower input power. In particular, the fully printed heaters fabricated on a flexible substrate covering an area of 3.2 mm2 and operating at 9.5 V exhibit a maximum temperature point above 70 °C with a power consumption below 200 mW. Therefore, we have demonstrated that this technology paves the way for a cost-effective large-scale fabrication of flexible microheaters aimed to be integrated in flexible sensors.

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“…Most works published to date on integrated heating options have been resistive thin film heating elements [ 10 – 14 ], or integrated micro-Peltier cells, typically controlled externally, resulting in a minimally-instrumented device rather than a self-contained one. Integrated self-regulating heating would be an ideal candidate for non-instrumented NAATs [ 15 – 19 ], but has not become widespread yet due to the aforementioned technical limitations of space and power. Furthermore, per-device cost is a factor significantly limiting the development of disposable rapid tests that rely on electrical temperature control.…”

Section: Introductionmentioning

confidence: 99%

Integrated self-regulating resistive heating for isothermal nucleic acid amplification tests (NAAT) in Lab-on-a-Chip (LoC) devices

Pardy

Tulp²,

Kremer³

et al. 2017

PLoS ONE

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Isothermal nucleic acid amplification tests (NAAT) in a Lab-on-a-Chip (LoC) format promise to bring high-accuracy, non-instrumented rapid tests to the point of care. Reliable rapid tests for infectious diseases allow for early diagnosis and treatment, which in turn enables better containment of potential outbreaks and fewer complications. A critical component to LoC NAATs is the heating element, as all NAAT protocols require incubation at elevated temperatures. We propose a cheap, integrated, self-regulating resistive heating solution that uses 2xAAA alkaline batteries as the power source, can maintain temperatures in the 60–63°C range for at least 25 minutes, and reaches the target range from room temperature in 5 minutes. 4 heating element samples with different electrical characteristics were evaluated in a thermal mock-up for a LoC NAAT device. An optimal heating element candidate was chosen based on temperature profiling. The optimal candidate was further evaluated by thermal modelling via finite element analysis of heat transfer and demonstrated suitable for isothermal nucleic acid amplification.

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Investigation on the temperature distribution of integrated heater configurations in a Lab-on-a-Chip system

Cited by 3 publications

References 5 publications

Design methodology and results evaluation of a heating functionality in modular lab-on-chip systems

Design methodology and results evaluation of a heating functionality in modular lab-on-chip systems

Printed and Flexible Microheaters Based on Carbon Nanotubes

Integrated self-regulating resistive heating for isothermal nucleic acid amplification tests (NAAT) in Lab-on-a-Chip (LoC) devices

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