The present work deals with the fatigue behavior of hybrid nanocomposites consisting epoxy strengthen by unidirectional carbon fibres, and/or woven roving glass fiber and TiO 2 nanofillers. For this purpose, nanocomposite material was manufactured by mixing TiO 2 nanoparticles with the epoxy using an ultrasonic mixer to insure complete dispersion of such particles in the base material. Different particle concentrations (1, 3, and 5) % wt. of TiO 2 nanoparticles have been added to the epoxy. Different types of hybrid nano composite materials were manufactured by adding three layers of carbon fibers and/or woven roving glass fiber to the prepared epoxy nanocomposite materials with a constant weight fraction of 30%. The laminated hybrid nanocomposite materials were then prepared using hand lay-up technique using a vacuum device. For experimental purposes tensile and fatigue test specimens have been manufactured according to ASTM-D3039 and ASTM D 3479/D 3479M-96, respectively, while ANSYS19 program was used to analyze the fatigue behavior of such materials numerically. Tensile tests were carried out at room temperature while fatigue tests has been carried out at constant stress ratio (R=-1). Scanning electron microscope (SEM) was used to identify the underlying mechanisms for fatigue failure and the progressive of damage growth. For each test, three specimens were tested and the average magnitude for each property was taken. The results obtained indicated that the hybrid nanocomposite (EP+C/C/C+3% TiO 2 ) has the highest fatigue limit and tensile strength in comparison with the other tested material, while the SEM results showed that the composite failed by a brittle way. It has been also generally observed that the addition of (TiO 2 ) nanoparticles has a positive effect on the fatigue behaviour of the such materials.