Investigation the cytotoxicity and photo-induced toxicity of carbon dot on yeast cell

Bagheri, Zeinab; Ehtesabi, Hamide; Hallaji, Zahra; Latifi, Hamid; Behroodi, Ebrahim

doi:10.1016/j.ecoenv.2018.05.071

Cited by 44 publications

(15 citation statements)

References 29 publications

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“…Bagheri et al observed a positive correlation between toxicity and the length of time yeast cells were exposed to PCDs under light, where the concentration of intracellular ROS increased with increasing irradiation time. 51 In addition to light-induced ROS generation by CDs, byproducts of CD degradation are also a potential toxicity concern. 52−54 Both PCDs and GQDs rapidly transform under natural sunlight, producing lower-molecular-weight compounds.…”

Section: Light Irradiationmentioning

confidence: 99%

Synthesis Processes, Photoluminescence Mechanism, and the Toxicity of Amorphous or Polymeric Carbon Dots

2022

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Conspectus Fluorescence is the emission of light following photon absorption. This optical phenomenon has many applications in daily life, such as in LED lamps, forensics, and bioimaging. Traditionally, small-molecule fluorophores were most common, but the types of molecules and particles with compelling fluorescence properties have expanded. For example, green fluorescent protein (GFP) was isolated from jellyfish and won the Nobel prize in 2008 due to its significant utility as a fluorescent biomarker. Using the intrinsic fluorescence of GFP, many previously invisible biological processes and substances can now be observed and studied. Other fluorescent materials have also been developed, greatly expanding the potential applications. Semiconductor quantum dots (QDs), which have bright fluorescence and a narrow bandwidth, are a popular choice for display technologies. However, QDs are made of heavy metal elements such as Cd and Se, which pose potential safety concerns to the environment and human health. Thus, new fluorescent organic materials are being developed to mitigate the toxicological concerns while maintaining the QD advantages. One type of new material attracting great attention as an environmentally friendly substitute for semiconductor QDs is carbon dots (CDs). CDs have been developed with strong fluorescence, good photostability, and low toxicity using a variety of precursors, and some synthesis processes have good potential for scale-up. However, since they are made of a variety of materials and through different methods, the structure and properties of CDs can differ from preparation to preparation. There are three major types of CDs: graphene quantum dots (GQDs), carbon quantum dots (CQDs), and amorphous or polymeric carbon dots (PCDs). This Account focuses on PCDs and their unique properties by comparing it with other types of CDs. The synthesis processes, fluorescence properties, fluorescence mechanisms, and toxicity are discussed below with an emphasis on the distinct attributes of PCDs. PCDs can be synthesized from small molecules or polymers. They have an amorphous or cross-linked polymer structure with bright fluorescence. This fluorescence is possibly due to cross-link-enhanced emission or clusteroluminescence that arises from the through-space interactions of heteroatomic-rich functional groups. Other fluorescence mechanisms of CDs, including distinct contributions from the carbon core and surface states, may also contribute. The toxicological profiles of CDs are influenced by the chemical composition, surface functionalization, and light illumination. CDs are generally thought to be of low toxicity, and this can be further improved by removing toxic byproducts, functionalizing the surface, and reducing light exposure to minimize the generation of reactive oxygen species.

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Section: Light Irradiationmentioning

confidence: 99%

Synthesis Processes, Photoluminescence Mechanism, and the Toxicity of Amorphous or Polymeric Carbon Dots

2022

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“…The absence of toxic effects in the cells is possibly due to the significantly smaller size of C dots, its higher hydrosolubility, and a greater degree of oxidation [ 165 ]. However, C dots were found to, in a dose-dependent manner, generate a ROS response in yeast cells, and this was further enhanced after light exposure [ 143 ]. A study by Havrdova et al [ 58 ] demonstrated that, depending on the surface modification, CDs exhibited different levels of toxicity in mouse fibroblasts.…”

Section: Biological Effects Of Carbon Nanomaterialsmentioning

confidence: 99%

The Puzzling Potential of Carbon Nanomaterials: General Properties, Application, and Toxicity

et al. 2020

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Being a member of the nanofamily, carbon nanomaterials exhibit specific properties that mostly arise from their small size. They have proved to be very promising for application in the technical and biomedical field. A wide spectrum of use implies the inevitable presence of carbon nanomaterials in the environment, thus potentially endangering their whole nature. Although scientists worldwide have conducted research investigating the impact of these materials, it is evident that there are still significant gaps concerning the knowledge of their mechanisms, as well as the prolonged and chronic exposure and effects. This manuscript summarizes the most prominent representatives of carbon nanomaterial groups, giving a brief review of their general physico-chemical properties, the most common use, and toxicity profiles. Toxicity was presented through genotoxicity and the activation of the cell signaling pathways, both including in vitro and in vivo models, mechanisms, and the consequential outcomes. Moreover, the acute toxicity of fullerenol, as one of the most commonly investigated members, was briefly presented in the final part of this review. Thinking small can greatly help us improve our lives, but also obliges us to deeply and comprehensively investigate all the possible consequences that could arise from our pure-hearted scientific ambitions and work.

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“…Carbon and graphene quantum dots (CDs and GQDs), denoted as zero-dimensional (0D) nanomaterials, have gained increasing ground in the past years. Their exclusive electronic, fluorescent, photoluminescent, chemiluminescent and electrochemiluminescent features are those providing them with sensing potentiality [ [18] , [19] , [20] , [21] ]. Other merits of CDs include simple synthetic paths, cost-effective synthesis, inexpensive preparatory materials, water-solubility, low toxicity level, chemical stability and facile functionalization.…”

Section: Carbon Nanomaterials For Diagnostic Applicationsmentioning

confidence: 99%

Application of carbon nanomaterials in human virus detection

Ehtesabi

2020

Journal of Science: Advanced Materials and Devices

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Human-pathogenic viruses are still a chief reason for illness and death on the globe, as epitomized by the COVID-19 pandemic instigated by a coronavirus in 2020. Multiple novel sensors have been invented because diseases must be detected and diagnosed as early as possible, and recognition methods have to be carried out with minimal invasivity. Sensors have been particularly developed focusing on miniaturization by the use of nanomaterials for fabricating nanosensors. The nano-sized nature of nanomaterials and their exclusive optical, electronical, magnetical, and mechanical attributes can enhance patient care through the use of sensors with minimal invasivity and extreme sensitivity. Amongst the nanomaterials utilized for fabricating nano-sensors, carbon-based nanomaterials are promising as these sensors respond better to signals in various sensing settings. This review provides an overview of the recent developments in carbon nanomaterial-based biosensors for viral recognition based on the biomarkers that arise from the infection, the nucleic acids from the viruses, and the entire virus. The role of carbon nanomaterials is highlighted by the improvement of sensor and recognition functionality. The Dengue virus, Ebola virus, Hepatits virus, human immunodeficiency virus (HIV), influenza virus, Zika virus and Adenovirus are the virus types reviewed to illustrate the implementation of the techniques. Finally, the drawbacks and advantages of carbon nanomaterial-based biosensors for viral recognition are identified and discussed.

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Investigation the cytotoxicity and photo-induced toxicity of carbon dot on yeast cell

Cited by 44 publications

References 29 publications

Synthesis Processes, Photoluminescence Mechanism, and the Toxicity of Amorphous or Polymeric Carbon Dots

Synthesis Processes, Photoluminescence Mechanism, and the Toxicity of Amorphous or Polymeric Carbon Dots

The Puzzling Potential of Carbon Nanomaterials: General Properties, Application, and Toxicity

Application of carbon nanomaterials in human virus detection

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