Investigation the effect of Silver nanoparticles on Sensitivity enhancement ratio in Improvement of Adipose Tissue Radiotherapy Using High Energy Photons

Abstract

Reducing the number of radiotherapy sessions is the primary goal of the radiotherapist domain. One of the most promising ways is to achieve this goal by adding nanoparticles as a contrast agent to the target where radiation is applied. The contribution of the nanoparticles will appear Sensitivity Enhancement Ratio (SER). SER is the ratio between the number of cancer cells destroyed by the presence of the contrast agent and the number of cells destroyed by the absence of the contrast agent for the same dose. Increasing the amount of SER indicates the increase in the number of destroyed cells compared with the number of destroyed cells in the absence of contrast agent. In this research, silver nanoparticles (AgNPs) were used as a contrast agent for adipose tissue cancer together with photons beam whose energy range from (2-15) MeV that applied to the adipose tissue loaded with AgNPs. The results showed an increase in the SER (1.44 with an energy of 15 MeV ), which would indicate a reduction in the number of radiotherapy sessions to become from five to three weeks depending on the energy of applied photon where the normal radiotherapy sessions are seven weeks.