Investigation the effect of sodium carboxymethylcellulose as polycounterion on cetirizine hydrochloride–sodium dodecyl sulphate mixed micelle

Kumar, Mukul; Raj, Shalya; Thapa, Uttam; Singh, Sandeepika; Srivastava, Anirudh

doi:10.1016/j.molliq.2020.114973

Cited by 27 publications

(12 citation statements)

References 48 publications

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“…Another recent study addressed the case of employing the identically charged surfactant SDS and polyanion sodium carboxymethyl cellulose (NaCMC) for the complexation of the cationic drug cetirizine hydrochloride (CTZ, used against allergies). This systematic study showed the formation of mixed micelles of SDS and CTZ whose cmc could be lowered further by the presence of NaCMC, which allowed for tuning the system’s properties via the amount of NaCMC present . This is a case where the drug electrostatically interacts with the surfactant.…”

Section: Pescs Employed In Drug Deliverymentioning

confidence: 86%

“…This systematic study showed the formation of mixed micelles of SDS and CTZ whose cmc could be lowered further by the presence of NaCMC, which allowed for tuning the system's properties via the amount of NaCMC present. 75 This is a case where the drug electrostatically interacts with the surfactant. A system where the charge conditions can rather easily become modified has been described recently for the case of pillar [5]arene, where the charge depends on the modification (anionic carboxy or cationic ammonium) of the polymer backbone.…”

Section: ■ Pescs Employed In Drug Deliverymentioning

confidence: 99%

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Polyelectrolyte–Surfactant Complexes As a Formulation Tool for Drug Delivery

Gradzielski

2022

Langmuir

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Aqueous polyelectrolyte−surfactant complexes (PESCs) are very rich with respect to their properties and the structures formed by them. By design they normally contain hydrophobic micellar surfactant aggregates complexed by long polyelectrolyte chains, thereby combining the formation of small hydrophobic domains given by the surfactant with large-scale structuring due to the presence of the polyelectrolyte chain. In addition, they contain highly polar regions of surfactant head groups in contact with polyelectrolyte, forming a shell around the micellar aggregates, which often also possesses a certain hydrophobic character. Accordingly, the ability for solubilization of waterinsoluble compounds of different sorts is particularly versatile in PESCs. Their solubilization sites with very different polarities and hydrophobic characters make them very flexible in adapting to the requirements of a given drug molecule. This renders them attractive for potential applications in drug delivery. In addition, modification of the rheological properties via self-assembly and network formation can be very important in PESC applications. In the following, we discuss the structures of PESCs and their properties, with a focus on the solubilization properties. Subsequently, examples are described where PESCs have been employed in the context of drug solubilization and delivery. These comprise examples with individual aggregates, cross-linked hydrogels, and ones taking advantage of the high solubilization capacity of microemulsions.

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Section: Pescs Employed In Drug Deliverymentioning

confidence: 86%

Section: ■ Pescs Employed In Drug Deliverymentioning

confidence: 99%

Polyelectrolyte–Surfactant Complexes As a Formulation Tool for Drug Delivery

Gradzielski

2022

Langmuir

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“…Other studies have already reported on the variance of N m values. 13,14,19,28,29,32,40,41 For instance, Caetano and Tabak 45 Furthermore, the K b value was determined using the slope and intercept data from Figure 8. For DPC and CPM, the values of log K b were 2.232 and 2.837, respectively.…”

Section: Binding Constant Of Dpc and Cpmmentioning

confidence: 99%

“…25−27 Our research groups are currently investigating the micellization properties of surfactants in the presence of organic additives such as ionic drugs, dyes, and polyelectrolytes in the aqueous medium. 13,14,19,28,29 Antihistaminic medications were widely used for their ability to make weakly water-soluble substances soluble in an aqueous environment. Shah and Flanagan 30 self-associations of antihistamine drug salts on the dissolution of salicylamide and acetaminophen in water-based solutions.…”

Section: Introductionmentioning

confidence: 99%

“…Many more investigators have shown in recent years which organic counterions can improve the micellization functions of surfactants in the aqueous medium, for example, tetraethyl and tetra- n -propylammonium, n -alkyl carboxylate ions and tetraalkylammonium counterions. − Our research groups are currently investigating the micellization properties of surfactants in the presence of organic additives such as ionic drugs, dyes, and polyelectrolytes in the aqueous medium. ,,,, …”

Section: Introductionmentioning

confidence: 99%

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Counterion Association of Ionic Drugs with Sodium Tetradecyl Sulfate in the Aqueous Medium

Kumar,

Bhardwaj,

Elahi

et al. 2023

ACS Omega

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Binding and occupancy properties of gabapentin in mixed surfactant systems

Kumar,

Khushi,

Singh

et al. 2023

J Surfact & Detergents

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This research highlights the efficacy of mixed micellar systems as an innovative chemical formulation for improving the binding properties of active pharmaceutical drugs. The formulations based on the mole fraction were utilized for preparing mixed micelles with anionic sodium dioctyl sulfosuccinate (AOT) and sodium dodecyl sulphate (SDS). DLS measurements demonstrated the formation of small micelles and mixed micelles in SDS‐AOT combinations. A UV absorbance investigation demonstrated the effectiveness of the SDS‐AOT mixed micelles for determining the binding constant (Kb) and mean ion occupancy (i0) of the anticonvulsant gabapentin (GBP) drug. Kb values increased, but the occupancy (i) of GBP per micelle decreased by decreasing the mole fraction (α) of SDS from αSDS 0.9 to 0.1, predicting a shift in occupancy of drugs from the Palisade to the Stern layer. To get a better comprehension of micellization behavior and preferential interaction of the drugs under study, molecular docking studies were performed. According to the docking studies, the GBP displayed significant binding in the presence of SDS‐AOT when compared to pure SDS and AOT molecules. Ultimately, in pharmaceutical applications, mixed micelle played an important role in enhancing the binding and encapsulation efficiency of drugs.

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Investigation the effect of sodium carboxymethylcellulose as polycounterion on cetirizine hydrochloride–sodium dodecyl sulphate mixed micelle

Cited by 27 publications

References 48 publications

Polyelectrolyte–Surfactant Complexes As a Formulation Tool for Drug Delivery

Polyelectrolyte–Surfactant Complexes As a Formulation Tool for Drug Delivery

Counterion Association of Ionic Drugs with Sodium Tetradecyl Sulfate in the Aqueous Medium

Binding and occupancy properties of gabapentin in mixed surfactant systems

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