Investigational drugs for retinal vein occlusion

Bremond-Gignac, Dominique

doi:10.1080/13543784.2016.1181750

Cited by 7 publications

(3 citation statements)

References 49 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are two main types of RVO, branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO), which are classified according to the sites of occlusion [ 2 , 3 ]. Systemic vascular disorders including hypertension, arteriosclerosis, and diabetes mellitus, as well as genetic background and environmental factors have been associated with the risk of RVO [ 4 , 5 ]. Single nucleotide polymorphisms (SNPs) in several hemostasis-associated genes such as Factor V , Prothrombin ( Factor II ), and PAI-1 , may contribute to the pathogenesis of RVO [ 4 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Factor VG1691A is associated with an increased risk of retinal vein occlusion: a meta-analysis

Zou

Zhang

et al. 2017

Oncotarget

View full text Add to dashboard Cite

We performed a meta-analysis to investigate the association between the Factor V G1691A polymorphism and the risk of retinal vein occlusion (RVO). This analysis included 37 studies involving 2,510 cases and 3,466 controls. Factor V G1691A was associated with an increased risk of RVO in the allele, heterozygote, dominant, and carrier models (PA < 0.001, odds ratios >1), but not the homozygote or recessive models (PA > 0.05). Similar results were observed in a meta-analysis of central retinal vein occlusion (CRVO) and when comparing Caucasian subgroups to population-based controls. These data demonstrate that the G/A genotype of Factor V G1691A is associated with an increased risk of RVO/CRVO in a Caucasian population.

show abstract

Section: Introductionmentioning

confidence: 99%

Factor VG1691A is associated with an increased risk of retinal vein occlusion: a meta-analysis

Zou

Zhang

et al. 2017

Oncotarget

View full text Add to dashboard Cite

show abstract

“…Anti-VEGF drugs intravitreally injected as innovative therapeutic approaches [ 43 ] while recent studies support the use of intravitreal dexamethasone implants in patients with retinal vascular diseases, especially in those with macular edema [ 3 , 10 – 14 ]. Novel cellular therapies such as MSCs' application may be also useful due to the favorable effect of the paracrine action of these cells [ 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Intravitreal Administration Effect of Adipose-Derived Mesenchymal Stromal Cells Combined with Anti-VEGF Nanocarriers, in a Pharmaceutically Induced Animal Model of Retinal Vein Occlusion

Gounari

Komnenou

Kofidou

et al. 2022

Stem Cells International

View full text Add to dashboard Cite

Antiangiogenic therapeutic agents (anti-VEGF) have contributed to the treatment of retinal vein occlusion (RVO) while mesenchymal stromal cell- (MSCs-) mediated therapies limit eye degeneration. The aim of the present study is to determine the effect of adipose-derived MSCs (ASCs) combination with nanocarriers of anti-VEGF in a pharmaceutically induced animal model of RVO. Nanoparticles (NPs) of thiolated chitosan (ThioCHI) with encapsulated anti-VEGF antibody were prepared. ASCs were isolated and genetically modified to secrete the green fluorescence GFP. Twenty-four New Zealand rabbits were divided into the I-IV equal following groups: ASCs, ASCs + nanoThioCHI-anti-VEGF, RVO, and control. For the RVO induction, groups I-III received intravitreal (iv) injections of MEK kinase inhibitor, PD0325901. Twelve days later, therapeutic regiments were administered at groups I-II while groups III-IV received BSS. Two weeks later, the retinal damage evaluated via detailed ophthalmic examinations, histological analysis of fixed retinal sections, ELISA for secreted cytokines in peripheral blood or vitreous fluid, and Q-PCR for the expression of related to the occlusion and inflammatory genes. Mild retinal edema and hemorrhages, limited retinal detachment, and vasculature attenuation were observed in groups I and II compared with the pathological symptoms of group III which presented a totally disorganized retinal structure, following of positive immunostaining for neovascularization and related to RVO markers. Important reduction of the high secreted levels of inflammatory cytokines was quantified in groups I and II vitreous fluid, while the expression of the RVO-related and inflammatory genes has been significantly decreased especially in group II. GFP+ ASCs, capable of being differentiated towards neural progenitors, detected in dissociated retina tissues of group II presenting their attachment to damaged area. Conclusively, a stem cell-based therapy for RVO is proposed, accompanied by sustained release of anti-VEGF, in order to combine the paracrine action of ASCs and the progressive reduction of neovascularization.

show abstract

“…Retinal vein occlusion is the second most common retinal vascular disease (1,2) . In branch retinal vein occlusion (BRVO), blockage occurs in a branch of the retinal veins alone (3)(4)(5) . Visual prognosis depends on the presence of macular edema (6,7) and the extent of the areas of non-perfusion (3,8) .…”

Section: Introductionmentioning

confidence: 99%

Avaliação da vasculatura da retina em pacientes com oclusão de ramo da veia central da retina utilizando a angiografia por tomografia de coerência óptica

Moura¹,

Lira²,

Arantes³

et al. 2020

Arquivos Brasileiros De Oftalmologia

View full text Add to dashboard Cite

To evaluate vascular density in super ficial and deep capillary plexuses of the retina, measured using optical coherence tomography angiography in patients with branch retinal vein occlusion. Affected eyes were compared with the contralateral eye of the same patient and both were compared with normal eyes. Methods: A cross-sectional study including 16 previously untreated patients with branch retinal vein occlusion. Patients with poor quality examinations, bilateral disease, high refractive error, or any other retinal or choroidal disease were excluded. A total of 31 patients without eye disease were also selected as a comparison group. All participants underwent five optical coherence tomography angiographies, and only those with at least two good quality examinations were selected. The Kruskal-Wallis, Wilcoxon signed-rank, and Mann-Whitney U tests were used for the statistical analysis. Results: Vascular density was lower in affected eyes compared with contralateral eyes: whole density (p=0.020 for capillary plexuses superficial; p=0.049 for deep capillary plexuses) and parafoveal density (p=0.020 for capillary plexuses superficial; p=0.011 for deep capillary plexuses). Vascular density was also lower in affected eyes compared with normal eyes: whole density (p<0.001 for capillary plexuses superficial and deep) and parafoveal density (p<0.001 for capillary plexuses superficial and deep). Whole density (p=0.001 for capillary plexuses superficial and deep) and parafoveal density (p=0.001 for capillary plexuses superficial; p<0.001 for deep capillary plexuses) were both lower in the contralateral eyes compared with normal eyes. Following adjustment for arterial hypertension, this difference was no longer observed. Conclusions: Vascular density in capillary plexuses and deep capillary plexuses was lower in the eyes affected by branch retinal vein occlusion. Furthermore, the lower vascular density noted in the contralateral eyes indicates that changes most likely occurred in these eyes prior to the appearance of any clinically detectable alterations, reflecting the early signs of hypertensive retinopathy.

show abstract

Investigational drugs for retinal vein occlusion

Cited by 7 publications

References 49 publications

Factor VG1691A is associated with an increased risk of retinal vein occlusion: a meta-analysis

Factor VG1691A is associated with an increased risk of retinal vein occlusion: a meta-analysis

Intravitreal Administration Effect of Adipose-Derived Mesenchymal Stromal Cells Combined with Anti-VEGF Nanocarriers, in a Pharmaceutically Induced Animal Model of Retinal Vein Occlusion

Avaliação da vasculatura da retina em pacientes com oclusão de ramo da veia central da retina utilizando a angiografia por tomografia de coerência óptica

Contact Info

Product

Resources

About