The liquid oxygen/methane staged cycle liquid-rocket engine is one of the most potential rocket engines in the future for its higher performance, higher fuel density and reusable capacity. Two working states of this liquid-rocket engine named as full-load state and half-load state are defined in this paper. Based on this liquid-rocket engine, a dual-rocket-basedcombined-cycle propulsion system with liquid oxygen /air/methane as propellants is therefore proposed. The dualrocket-based-combined-cycle system has then five working modes: the hybrid mode, pure ejector mode, ramjet mode, scramjet mode and pure rocket mode. In hybrid mode, the booster and ejector rockets driven by the full-load liquidrocket engine work together with the purpose of reducing thrust demand on ejector rocket. In scramjet mode, the fuelrich burned hot gas generated by the half-load liquid-rocket engine is used as fuel, which is helpful to reduce the technical difficulty of scramjet in hypersonic speed. The five working modes of dual-rocket-based-combined-cycle are highly integrated based on the full-or half-load state of the liquid oxygen/methane staged cycle liquid-rocket engine, and the unified single type fuel of liquid methane is adopted for the whole modes. Then a preliminary design of a horizontal takeoff two-stage-to-orbit launch vehicle is conducted based on the dual-rocket-based-combined-cycle propulsion system. Under an averaged baseline thrust and specific impulse, the launch trajectory to reach a low Earth orbit at 100 km is optimized via the pseudo-spectral method subject to maximizing the payload mass. It is shown that the two-stage-to-orbit vehicle based on the dual-rocket-based-combined-cycle can achieve the payload mass fraction of 0.0469 and 0.0576 for polar mission and equatorial mission, respectively. Conclusively, insights gained in this paper can be usefully applied to a more detailed design of the dual-rocket-based-combined-cycle powered two-stage-to-orbit launch vehicle.