Abstract:Investigations and management of chronic cough 789 Society (ERS) recently commissioned a task force on the management of chronic cough and the purpose of this review is to highlight the key messages from the most recent guideline. 7Causes of chronic cough Chronic cough can occur with respiratory conditions such as asthma, chronic obstructive pulmonary disease, bronchiectasis, interstitial lung disease, and occasionally with lung cancer. The most common causes of chronic cough in patients with a normal chest x … Show more
“…Smoking is a well-known causative factor of chronic cough 16,20,27 , but the fact that former smokers and never smokers have similar prevalence of chronic cough at each age group is reassuring and suggests smoking cessation should be the foremost target for intervention in all clinical encounters in primary and secondary care [28][29][30] . This study also extends the harmful respiratory manifestations of smoking by demonstrating that airflow obstruction, COPD and a lower FEV1% predicted are all associated with a higher prevalence of chronic cough.…”
The global prevalence of chronic cough(CC) is highly variable ranging from 2–18%. There is a lack of data on the prevalence and incidence of CC from the general population. The objective of this study was to investigate the prevalence and incidence of CC in a sample of Canadian adults, and how these influenced by age, sex, smoking, respiratory symptoms, medical co-morbidities, and lung function.Participants with chronic cough were identified from the Canadian Longitudinal Study on Ageing (CLSA) based on a self-reported daily cough in the last 12 months. This is a prospective, nationally generalisable, stratified random sample of adults aged 45–85 at baseline recruited between 2011–2015, and followed-up 3 years later. The prevalence and incidence per-100-person-years are described, with adjustments for age, sex and smoking.Of the 30 097 participants, 29 972 completed the CC question at baseline and 26 701 at follow-up. The prevalence of CC was 15.8% at baseline and 17.6% at follow-up with 10.4%–17.1% variation across 7 provinces included in the CLSA comprehensive sample. Prevalence increased with age, current smoking, and was higher in males(15.2%), Caucasians(14%), and those born in North America, Europe or Oceania(14%). The incidence of CC adjusted for age, sex and smoking was higher in males, underweight and obese. Respiratory symptoms, airways diseases, lower FEV1%predicted, cardio-vascular diseases, psychological disorders, diabetes and chronic pain had a higher incidence of CC.The prevalence and incidence of CC is high in the CLSA sample with geographic, ethnic and gender differences which is influence by a number of medical co-morbidities.
“…Smoking is a well-known causative factor of chronic cough 16,20,27 , but the fact that former smokers and never smokers have similar prevalence of chronic cough at each age group is reassuring and suggests smoking cessation should be the foremost target for intervention in all clinical encounters in primary and secondary care [28][29][30] . This study also extends the harmful respiratory manifestations of smoking by demonstrating that airflow obstruction, COPD and a lower FEV1% predicted are all associated with a higher prevalence of chronic cough.…”
The global prevalence of chronic cough(CC) is highly variable ranging from 2–18%. There is a lack of data on the prevalence and incidence of CC from the general population. The objective of this study was to investigate the prevalence and incidence of CC in a sample of Canadian adults, and how these influenced by age, sex, smoking, respiratory symptoms, medical co-morbidities, and lung function.Participants with chronic cough were identified from the Canadian Longitudinal Study on Ageing (CLSA) based on a self-reported daily cough in the last 12 months. This is a prospective, nationally generalisable, stratified random sample of adults aged 45–85 at baseline recruited between 2011–2015, and followed-up 3 years later. The prevalence and incidence per-100-person-years are described, with adjustments for age, sex and smoking.Of the 30 097 participants, 29 972 completed the CC question at baseline and 26 701 at follow-up. The prevalence of CC was 15.8% at baseline and 17.6% at follow-up with 10.4%–17.1% variation across 7 provinces included in the CLSA comprehensive sample. Prevalence increased with age, current smoking, and was higher in males(15.2%), Caucasians(14%), and those born in North America, Europe or Oceania(14%). The incidence of CC adjusted for age, sex and smoking was higher in males, underweight and obese. Respiratory symptoms, airways diseases, lower FEV1%predicted, cardio-vascular diseases, psychological disorders, diabetes and chronic pain had a higher incidence of CC.The prevalence and incidence of CC is high in the CLSA sample with geographic, ethnic and gender differences which is influence by a number of medical co-morbidities.
“… Fig. 11 Conduction pathway of cough reflex [ 7 , 8 , [16] , [17] , [18] , [19] ]. The underline part could be affected by gabapentin.…”
Section: Discussionmentioning
confidence: 99%
“…They have noticed that chronic cough was very similar to chronic pain, and it, like chronic pain, may also be a neurological disease in some aspects [ 6 , 7 ]. Therefore, some drugs for neurological diseases, especially for chronic pain, have the potential of treating chronic cough [ 1 , [6] , [7] , [8] ]. Gabapentin, one of the drugs for neurological diseases, is a typical drug for chronic pain and epilepsy, and was first investigated in the treatment of chronic cough from 2005 [ 9 ].…”
“…Probably GERD should be viewed as a possible contributing factor in some BA patients. frequently as men and which has a significant impact on the quality of life (QoL) of these patients [25]. The reason behind this gender-related prevalence is still unclear, but it is possible that respiratory tract anatomy, hormonal differences and increased sensitivity to cough reflex in women might play a role [25,26].…”
Section: Statement 1 Gastroesophageal Reflux Disease (Gerd) May Cause...mentioning
Background and Aims: Gastroesophageal reflux disease (GERD) is a common condition present in daily practice with a wide range of clinical phenotypes. In this line, respiratory conditions may be associated with GERD. The Romanian Societies of Gastroenterology and Neurogastroenterology, in association with the Romanian Society of Pneumology, aimed to create a guideline regarding the epidemiology, diagnosis and treatment of respiratory conditions associated with GERD.Methods: Delphi methodology was used and eleven common working groups of experts were created. The experts reviewed the literature according to GRADE criteria and formulated 34 statements and recommendations. Consensus (>80% agreement) was reached for some of the statements after all participants voted.Results: All the statements and the literature review are presented in the paper, together with their correspondent grade of evidence and the voting results. Based on >80% voting agreement, a number of 22 recommendations were postulated regarding the diagnosis and treatment of GERD-induced respiratory symptoms. The experts considered that GERD may cause bronchial asthma and chronic cough in an important number of patients through micro-aspiration and vagal-mediated tracheobronchial reflex. GERD should be suspected in patients with asthma with suboptimal controlled or after exclusion of other causes, also in nocturnal refractory cough which needs gastroenterological investigations to confirm the diagnosis. Therapeutic test with double dose proton pump inhibitors (PPI) for 3 months is also useful. GERD induced respiratory conditions are difficult to treat; however,proton pump inhibitors and laparoscopic Nissen fundoplication are endorsed for therapy.Conclusions: This guideline could be useful for the multidisciplinary management of GERD with respiratory symptoms in current practice.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
