Investigations into the inheritance of orthodontic malformations

Korkhaus, G.

doi:10.1016/s0099-6963(31)80070-5

Cited by 10 publications

(5 citation statements)

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“…Familial occurrence of class II/division 2 deep-bite has been attested in several literature publishments including twin and triplet reports by Kloeppel, [6] Markovic [7] and Litt and Nielsen [8] and pedigree studies by Korkhaus [9] and Trauner. [10] Peck et al [11] declared that these studies points to indisputable genetic influence, probably of an autosomal dominant type with incomplete penetrance, as a critical element in the formation and expression of Angle's class II/division 2 deep-bite malocclusion.…”

Section: Discussionmentioning

confidence: 99%

Multiple tooth anomalies in a nonsyndromic patient with class II division 2 malocclusions: A case report and a literature review

İşman

Aktan

et al. 2015

Niger J Clin Pract

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Reports in the literature about the craniofacial characteristics of patients with class II division 2 malocclusions show a lot of different patterns accompanied by palatally displaced upper incisors, congenital missing teeth, polydiastema, fusion, germination, tooth impaction, peg-shaped lateral incisors, persistent teeth, hypodontia, persistent deciduous teeth, transpositions, and supernumerary teeth. The following case report focuses on the description of the clinical characteristics observed on a patient with a very unusual conjunction of dental and skeletal anomalies mentioned above, as well as a literature review on the related issues. Extra-intra-oral examinations, radiographic evaluations, orthodontic consultation, and reviewing the literature concluded that this nonsyndromic patient that refused to receive all dental treatment approaches is special with its uniqueness.

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Section: Discussionmentioning

confidence: 99%

Multiple tooth anomalies in a nonsyndromic patient with class II division 2 malocclusions: A case report and a literature review

İşman

Aktan

et al. 2015

Niger J Clin Pract

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“…47 Extensive cephalometric studies by Harris suggested the concept of polygenic inheritance for Class II division 1 malocclusion, showing that the craniofacial skeletal patterns of children with class II malocclusions are heritable and that there is a high resemblance to the skeletal patterns in their siblings with normal occlusion. 48 Familial occurrence of Class II division 2 has been documented in several published reports including twin and triplet studies (Kloeppel; Markovic) and family pedigrees from Korkhaus, Rubbrecht, Trauner, 49 and Peck et al 50 Twin studies showed that the identical twins demonstrated 100% concordance for Class II division 2 malocclusion, indicating a strong genetic influence in the development of Class II division 2 deep bite malocclusions. 51 Markovic's clinical and cephalometric study of intra-and interpair comparisons of 114 Class II division 2 malocclusions, 48 twin pairs, and six sets of triplets showed complete penetrance and variable expressivity of autosomal dominant genetic impression.…”

Section: Effects Of Genetics On Inheritance Of Malocclusionmentioning

confidence: 96%

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2020

Global Medical Genetics

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The development of craniofacial complex and dental structures is a complex and delicate process guided by specific genetic mechanisms. Genetic and environmental factors can influence the execution of these mechanisms and result in abnormalities. An insight into the mechanisms and genes involved in the development of orofacial and dental structures has gradually gained by pedigree analysis of families and twin studies as well as experimental studies on vertebrate models. The development of novel treatment techniques depends on in-depth knowledge of the various molecular or cellular processes and genes involved in the development of the orofacial complex. This review article focuses on the role of genes in the development of nonsyndromic orofacial, dentofacial variations, malocclusions, excluding cleft lip palate, and the advancements in the field of molecular genetics and its application to obtain better treatment outcomes.

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“…In the 1930s, a German orthodontist and a Belgian physician introduced the orthodontic community to the idea developed in quantitative population genetics that the study of twins provides a unique approach to separate the relative contributions of heredity and environment to physical constitution. 33,36 From that point on, during the late 1930s and throughout the 1950s, much of orthodontic research focused on family pedigrees and especially on the study of twins from the perspectives of Mendelian genetics. [37][38][39][40][41][42][43] Virtually all of those studies tended to support the newly popular opinion that heredity determines the size and shape of the jaws in both normal and abnormal development and growth.…”

Section: Concepts Of Heredity and Genetics In Orthodonticsmentioning

confidence: 99%

Evolving concepts of heredity and genetics in orthodontics

Carlson

2015

American Journal of Orthodontics and Dentofacial Orthopedics

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The field of genetics emerged from the study of heredity early in the 20th century. Since that time, genetics has progressed through a series of defined eras based on a number of major conceptual and technical advances. Orthodontics also progressed through a series of conceptual stages over the past 100 years based in part on the ongoing and often circular debate about the relative importance of heredity (nature) and the local environment (nurture) in the etiology and treatment of malocclusion and dentofacial deformities. During the past 20 years, significant advancements in understanding the genomic basis of craniofacial development and the gene variants associated with dentofacial deformities have resulted in a convergence of the principles and concepts in genetics and in orthodontics that will lead to significant advancement of orthodontic treatments. Fundamental concepts from genetics and applied translational research in orthodontics provide a foundation for a new emphasis on precision orthodontics, which will establish a modern genomic basis for major improvements in the treatment of malocclusion and dentofacial deformities as well as many other areas of concern to orthodontists through the assessment of gene variants on a patient-by-patient basis.

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Investigations into the inheritance of orthodontic malformations

Cited by 10 publications

References 0 publications

Multiple tooth anomalies in a nonsyndromic patient with class II division 2 malocclusions: A case report and a literature review

Multiple tooth anomalies in a nonsyndromic patient with class II division 2 malocclusions: A case report and a literature review

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Evolving concepts of heredity and genetics in orthodontics

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