Investigations into Vestibular Evoked Responses

Pirodda, E; Ghedini, S.; Zanetti, M.

doi:10.3109/00016488709109050

Cited by 18 publications

(6 citation statements)

References 15 publications

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“…Building on prior studies that have attempted to measure vestibular evoked potentials Elidan et al 1991;Hood and Kayan 1985;Nolan et al 2009Nolan et al , 2011Nolan et al , 2012Pirodda et al 1987;Probst et al 1995;Schneider et al 1996Schneider et al , 2001Todd et al 2014aTodd et al , 2014bTodd et al , 2014c; for more detail see DISCUSSION), here we report data from a new research platform that allowed us to investigate human cortical processing of natural VS by recording highdensity 192-channel EEG while participants underwent passive whole body yaw rotations. We performed two studies (total of 4 experiments) and analyzed event-related desynchronization of cortical oscillations and vestibular evoked potentials during transient and constant-velocity rotations in healthy participants and a cohort of patients diagnosed with bilateral vestibular loss.…”

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confidence: 99%

Oscillatory neural responses evoked by natural vestibular stimuli in humans

Gale

Prsa

Schurger

et al. 2016

Journal of Neurophysiology

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While there have been numerous studies of the vestibular system in mammals, less is known about the brain mechanisms of vestibular processing in humans. In particular, of the studies that have been carried out in humans over the last 30 years, none has investigated how vestibular stimulation (VS) affects cortical oscillations. Here we recorded high-density electroencephalography (EEG) in healthy human subjects and a group of bilateral vestibular loss patients (BVPs) undergoing transient and constant-velocity passive whole body yaw rotations, focusing our analyses on the modulation of cortical oscillations in response to natural VS. The present approach overcame significant technical challenges associated with combining natural VS with human electrophysiology and reveals that both transient and constant-velocity VS are associated with a prominent suppression of alpha power (8 -13 Hz). Alpha band suppression was localized over bilateral temporo-parietal scalp regions, and these alpha modulations were significantly smaller in BVPs. We propose that suppression of oscillations in the alpha band over temporo-parietal scalp regions reflects cortical vestibular processing, potentially comparable with alpha and mu oscillations in the visual and sensorimotor systems, respectively, opening the door to the investigation of human cortical processing under various experimental conditions during natural VS. EEG; vestibular processing; vestibular cortex THE VESTIBULAR SYSTEM encodes three-dimensional displacements of the head and its position relative to gravity. Vestibular signals are used for oculomotor and postural control but also underpin perceptual and cognitive functions, including visual perception according to internal models of gravity, spatial navigation, and bodily awareness (Brandt et al. 2005;Indovina et al. 2005;Lopez et al. 2010). In strong contrast with the growing number of functions shown to be under vestibular influence is the relative lack of data on the vestibular cortex in animals and humans (Angelaki and Cullen 2008;Brandt and Dieterich 1999;Lopez and Blanke 2011).Electrophysiological investigations in nonhuman primates have revealed vestibular responses in several areas of the cortex. These include the intraparietal sulcus and the somatosensory, temporal, frontal, and parieto-insular cortices (Bremmer et al. 2002;Grüsser et al. 1990aGrüsser et al. , 1990bGu et al. 2008;Liu et al. 2011;Schwarz and Fredrickson 1971). These areas form a cortical network of which the core is presumed to be located in the "parieto-insular vestibular cortex" (PIVC; Guldin and Grüsser 1998). Recently, descriptions of vestibular neurons' spatiotemporal tuning in these cortical regions have been achieved during three-dimensional passive rotations/ translations on motion platforms in nonhuman primates (e.g., Chen et al. 2011;Shinder and Newlands 2014;Takahashi et al. 2007).Investigations of the human vestibular cortex are challenging because neuroimaging techniques (fMRI, PET) do not allow head and body movements and thus the app...

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confidence: 99%

Oscillatory neural responses evoked by natural vestibular stimuli in humans

Gale

Prsa

Schurger

et al. 2016

Journal of Neurophysiology

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“…Finally, we note that other EEG investigations using whole-body rotations have identified independent components with peak latencies at 200 ms ( 50 , 182 ), or biphasic waves with peak latencies from 200 to 350 or 400 ms, maximally recorded at the vertex ( 49 , 52 , 178 , 179 , 183 , 184 ).…”

Section: Late Latency Vestibular-evoked Potentialsmentioning

confidence: 58%

Vestibular-Evoked Cerebral Potentials

2021

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The human vestibular cortex has mostly been approached using functional magnetic resonance imaging and positron emission tomography combined with artificial stimulation of the vestibular receptors or nerve. Few studies have used electroencephalography and benefited from its high temporal resolution to describe the spatiotemporal dynamics of vestibular information processing from the first milliseconds following vestibular stimulation. Evoked potentials (EPs) are largely used to describe neural processing of other sensory signals, but they remain poorly developed and standardized in vestibular neuroscience and neuro-otology. Yet, vestibular EPs of brainstem, cerebellar, and cortical origin have been reported as early as the 1960s. This review article summarizes and compares results from studies that have used a large range of vestibular stimulation, including natural vestibular stimulation on rotating chairs and motion platforms, as well as artificial vestibular stimulation (e.g., sounds, impulsive acceleration stimulation, galvanic stimulation). These studies identified vestibular EPs with short latency (<20 ms), middle latency (from 20 to 50 ms), and late latency (>50 ms). Analysis of the generators (source analysis) of these responses offers new insights into the neuroimaging of the vestibular system. Generators were consistently found in the parieto-insular and temporo-parietal junction—the core of the vestibular cortex—as well as in the prefrontal and frontal areas, superior parietal, and temporal areas. We discuss the relevance of vestibular EPs for basic research and clinical neuroscience and highlight their limitations.

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“…Additionally, potentials could not be recorded from two bilaterally labyrinthectomized patients using the same stimulation technique. Pirodda et al (8) compared the evoked responses in patients with bilateral and unilateral loss of vestibular function. They recorded no responses in the former patients, but obtained responses in the latter cases with any rotatory stimulation.…”

Section: Possibility Of Clinical Applicationsmentioning

confidence: 99%