Investigations of development process of high hollow beveled microneedles using a combination of ICP RIE and dicing saw

Baron, Nolwenn; Passave, J.; Guichardaz, Blandine; Cabodevila, Gonzalo

doi:10.1007/s00542-008-0596-1

Cited by 20 publications

(8 citation statements)

References 9 publications

(10 reference statements)

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“…Deep anisotropic etching, isotropic etching and mask technique were used to fabricate cylindrical microneedles with a side-opening orifice [150]. In addition to chemical etching methods, a dicing saw was used together with deep reactive ion etching to obtain hollow silicon microneedles with sharp tips [151]. …”

Section: Fabrication Of Microneedlesmentioning

confidence: 99%

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Microneedles for drug and vaccine delivery

Kim

Park

Prausnitz

2012

Advanced Drug Delivery Reviews

1,404

1,036

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Microneedles were first conceptualized for drug delivery many decades ago, but only became the subject of significant research starting in the mid-1990’s when microfabrication technology enabled their manufacture as (i) solid microneedles for skin pretreatment to increase skin permeability, (ii) microneedles coated with drug that dissolves off in the skin, (iii) polymer microneedles that encapsulate drug and fully dissolve in the skin and (iv) hollow microneedles for drug infusion into the skin. As shown in more than 350 papers now published in the field, microneedles have been used to deliver a broad range of different low molecular weight drugs, biotherapeutics and vaccines, including published human studies with a number of small-molecule and protein drugs and vaccines. Influenza vaccination using a hollow microneedle is in widespread clinical use and a number of solid microneedle products are sold for cosmetic purposes. In addition to applications in the skin, microneedles have also been adapted for delivery of bioactives into the eye and into cells. Successful application of microneedles depends on device function that facilitates microneedle insertion and possible infusion into skin, skin recovery after microneedle removal, and drug stability during manufacturing, storage and delivery, and on patient outcomes, including lack of pain, skin irritation and skin infection, in addition to drug efficacy and safety. Building off a strong technology base and multiple demonstrations of successful drug delivery, microneedles are poised to advance further into clinical practice to enable better pharmaceutical therapies, vaccination and other applications.

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Section: Fabrication Of Microneedlesmentioning

confidence: 99%

“…Images reproduced with permission from references (a) [148], (b) [149], (c) [145], (d) [150], (e) [151], (f) [156], (g) [168], (h) [345], (i) [163], (j) [317], and (k) [167]. …”

Section: Figurementioning

confidence: 99%

Microneedles for drug and vaccine delivery

Kim

Park

Prausnitz

2012

Advanced Drug Delivery Reviews

1,404

1,036

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“…In order to avoid the breakage of the top part of the needles inside the skin, microneedle array with biodegradable tips have been developed [117] Encapsulation of molecules within microneedles that dissolve within the skin for bolus or sustained delivery has also been studied [118]. Hollow microneedles have also been fabricated and used to flow drug solutions into the skin [119]. …”

Section: Therapeutic Applicationsmentioning

confidence: 99%

BioMEMS –Advancing the Frontiers of Medicine

James

Mannoor

Ivanov

2008

Sensors

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Biological and medical application of micro-electro-mechanical-systems (MEMS) is currently seen as an area of high potential impact. Integration of biology and microtechnology has resulted in the development of a number of platforms for improving biomedical and pharmaceutical technologies. This review provides a general overview of the applications and the opportunities presented by MEMS in medicine by classifying these platforms according to their applications in the medical field.

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“…Microneedles can fall into two categories: solid microneedle structures (Henry et al 1998;Wilke et al 2005) and hollow microneedle structures Baron et al 2008). Solid microneedles are either precoated with the drug or only used to create perforations in skins for subsequent local drug administration, each of these is not fit for the long-term and continuous drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Hollow metallic microneedles fabricated by combining bulk silicon micromachining and UV–LIGA technology

et al. 2011

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As one of the promising research aspects in BioMEMS, microneedle technology has been widely applied in drug delivery. Compared with the solid microneedles, hollow microneedles can provide continuous delivering drugs. However, the fabrication processes and costs of the hollow microneedles are often complex and high accordingly. We propose a low-cost method to fabricate the hollow metallic microneedles, which contains procedures of using a wet method to etch silicon wafer to get the tapered cavities firstly, filling the tapered cavities with the SU-8 photoresist, developing the SU-8 to pattern the shapes of microneedles, and electroplating one metal in the patterns to form hollow metallic microneedles. According to the method, microneedles with different shape tips that include the triangular pyramids or the rectangular pyramids have been fabricated. In addition, these microneedles have been analysed using a finite element method and tested on artificial skins, which demonstrate the strength of microneedles is sufficient for piercing skins.

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Investigations of development process of high hollow beveled microneedles using a combination of ICP RIE and dicing saw

Cited by 20 publications

References 9 publications

Microneedles for drug and vaccine delivery

Microneedles for drug and vaccine delivery

BioMEMS –Advancing the Frontiers of Medicine

Hollow metallic microneedles fabricated by combining bulk silicon micromachining and UV–LIGA technology

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