Investigations of face expertise in the social developmental disorders

Barton, Jason J.S.; Hefter, Rebecca; Cherkasova, Mariya V.; Manoach, Dara S.

doi:10.1212/01.wnl.0000267842.85646.f2

Cited by 29 publications

(16 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…When tested, patients with DP may have normal structural magnetic resonance imaging scans and may respond to faces with functional magnetic resonance activation in the fusiform face area (Avidan et al, 2005); however, there is much evidence that DP is associated with impaired configural processing of faces very similar to fusiform face area dysfunction (Barton et al, 2003, 2007a, 2007b; Huis in ‘t Veld et al, 2012). Because of this configural impairment, people with DP may revert, as did our participants, to sequential feature-by-feature inspection, particularly of salient features such as clothing, hairstyle, and eyebrows (Duchaine, 2000; Duchaine and Nakayama, 2004; Michelon and Biederman, 2003; Stollhoff et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Impairments in the Face-Processing Network in Developmental Prosopagnosia and Semantic Dementia

Mendez

Ringman

Shapira

2015

Cognitive and Behavioral Neurology

View full text Add to dashboard Cite

Background Developmental prosopagnosia (DP) and semantic dementia (SD) may be the two most common neurologic disorders of face processing, but their main clinical and pathophysiologic differences have not been established. To identify those features, we compared patients with DP and SD. Methods Five patients with DP, five with right temporal-predominant SD, and ten normal controls underwent cognitive, visual perceptual, and face-processing tasks. Results Although the patients with SD were more cognitively impaired than those with DP, the two groups did not differ statistically on the visual perceptual tests. On the face-processing tasks, the DP group had difficulty with configural analysis and they reported relying on serial, feature-by-feature analysis or awareness of salient features to recognize faces. By contrast, the SD group had problems with person knowledge and made semantically related errors. The SD group had better face familiarity scores, suggesting a potentially useful clinical test for distinguishing SD from DP. Conclusions These two disorders of face processing represent clinically distinguishable disturbances along a right hemisphere face-processing network: DP, characterized by early configural agnosia for faces, and SD, characterized primarily by a multimodal person knowledge disorder. We discuss these preliminary findings in the context of the current literature on the face-processing network; recent studies suggest an additional right anterior temporal, unimodal face familiarity-memory deficit consistent with an “associative prosopagnosia.”

show abstract

Section: Discussionmentioning

confidence: 99%

“…In a modification of the method reported by Barton et al (2007a), we showed participants front-view photographs of 20 anonymous (non-famous) individuals taken from public sources. We presented the photographs one at a time.…”

Section: Methodsmentioning

confidence: 99%

Impairments in the Face-Processing Network in Developmental Prosopagnosia and Semantic Dementia

Mendez

Ringman

Shapira

2015

Cognitive and Behavioral Neurology

View full text Add to dashboard Cite

show abstract

“…In addition, analysis of visual social stimuli and/or their evaluation as social signals may be impaired (Williams et al 2008 ). Autism spectrum disorder: Facial confi guration and eye gaze processing (Barton et al 2007 ;Hoehl et al 2009 ), facial identity recognition, and general visual recognition (Wilson et al , 2012, biological motion perception (Nackaerts et al 2012 ), visual exploration (Ozonoff et al 2008 ) have all been described as being defi cient. Features of 'dorsal stream dysfunction' have also been described (MacIntyre-Béon et al 2010 ).…”

Section: Disorders Of Brain Developmentmentioning

confidence: 99%

Cerebral Visual Impairment in Children

Zihl

Dutton

2015

View full text Add to dashboard Cite

“…In this perspective, tasks asking neurotypical individuals to assess the sameness of two faces usually report poorer performance when the standard spatial relation between the parts is distorted, as for upside-down faces (Valentine, 1988), composites made of two aligned half-faces from different people (Young et al, 1987), or faces with scrambled parts (Tanaka and Farah, 1993). However, studies implementing the same tasks in individuals with ASD have reported mixed findings with some describing them as not influenced (Van Der Geest et al, 2002; Joseph and Tanaka, 2003; Teunisse and de Gelder, 2003; Rondan and Deruelle, 2004; Riby et al, 2009) or less influenced than Controls (Hobson et al, 1988; López et al, 2004; Barton et al, 2007; Pellicano et al, 2007, see also Weigelt et al, 2012), but others describing equal effects as in neurotypical individuals (Teunisse and de Gelder, 2003; Rouse et al, 2004; Lahaie et al, 2006; Gross, 2008). Such variability could reflect the important heterogeneity of the ASD population, in which diagnostic symptoms are expressed differently across individuals, maybe confounded by age or attentional factors (Rondan and Deruelle, 2007), and/or possibly stem from the development of compensatory neuronal mechanisms (Gaigg, 2012; Dickstein et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Neural responses to emotional expression information in high- and low-spatial frequency in autism: evidence for a cortical dysfunction

Corradi‐Dell’Acqua

Schwartz

Meaux

et al. 2014

Front. Hum. Neurosci.

View full text Add to dashboard Cite

Despite an overall consensus that Autism Spectrum Disorder (ASD) entails atypical processing of human faces and emotional expressions, the role of neural structures involved in early facial processing remains unresolved. An influential model for the neurotypical brain suggests that face processing in the fusiform gyrus and the amygdala is based on both high-spatial frequency (HSF) information carried by a parvocellular pathway, and low-spatial frequency (LSF) information separately conveyed by a magnocellular pathway. Here, we tested the fusiform gyrus and amygdala sensitivity to emotional face information conveyed by these distinct pathways in ASD individuals (and matched Controls). During functional Magnetical Resonance Imaging (fMRI), participants reported the apparent gender of hybrid face stimuli, made by merging two different faces (one in LSF and the other in HSF), out of which one displayed an emotional expression (fearful or happy) and the other was neutral. Controls exhibited increased fusiform activity to hybrid faces with an emotional expression (relative to hybrids composed only with neutral faces), regardless of whether this was conveyed by LSFs or HSFs in hybrid stimuli. ASD individuals showed intact fusiform response to LSF, but not HSF, expressions. Furthermore, the amygdala (and the ventral occipital cortex) was more sensitive to HSF than LSF expressions in Controls, but exhibited an opposite preference in ASD. Our data suggest spared LSF face processing in ASD, while cortical analysis of HSF expression cues appears affected. These findings converge with recent accounts suggesting that ASD might be characterized by a difficulty in integrating multiple local information and cause global processing troubles unexplained by losses in low spatial frequency inputs.

show abstract

Investigations of face expertise in the social developmental disorders

Abstract: Background:Patients with social developmental disorders (SDD), also known as autism spectrum

Cited by 29 publications

References 82 publications

Impairments in the Face-Processing Network in Developmental Prosopagnosia and Semantic Dementia

Impairments in the Face-Processing Network in Developmental Prosopagnosia and Semantic Dementia

Cerebral Visual Impairment in Children

Neural responses to emotional expression information in high- and low-spatial frequency in autism: evidence for a cortical dysfunction

Contact Info

Product

Resources

About