Investigations of polycaprolactone/gelatin blends in terms of their miscibility

Kołbuk, Dorota; Denis, Piotr; Choińska, Emilia

doi:10.2478/bpasts-2013-0066

Cited by 14 publications

(26 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Poor evidence of substance peaks due to a small amount of this substance in different systems had been previously reported [35]. for all samples (PLC bulk, PCL nanofibers, and BIOG PCL nanofibers) [36,37]. The incorporation of BIOG nanoparticles into the polymeric nanofibers did not affect significantly the semicrystalline nature of the PCL and the volume fraction of PCL crystals within the material (since both the melting point and enthalpy of melting are similar for all samples).…”

Section: Resultsmentioning

confidence: 58%

Bioactive Glass Nanoparticles-Loaded Poly(ɛ-caprolactone) Nanofiber as Substrate for ARPE-19 Cells

Lima

Fernandes-Cunha

Jensen

et al. 2016

Journal of Nanomaterials

View full text Add to dashboard Cite

Bioactive glass nanoparticles-loaded poly(ɛ-caprolactone) nanofibers (BIOG PCL nanofibers) were synthesized and evaluated as substrates for ocular cells (ARPE-19). BIOG PCL nanofibers were characterized using SEM, FTIR, and DSC, and thein vitrodegradation profile was also investigated. Thein vitroocular biocompatibility of nanofibers was exploited in Müller glial cells (MIO-M1 cells) and in chorioallantoic membrane (CAM); and the proliferative capacity, cytotoxicity, and functionality were evaluated. Finally, ARPE-19 cells were seeded onto BIOG PCL nanofibers and they were investigated as supports forin vitrocell adhesion and proliferation. SEM images revealed the incorporation of BIOG nanoparticles into PCL nanofibers. Nanoparticles did not induce modifications in the chemical structure and semicrystalline nature of PCL in the nanofiber, as shown by FTIR and DSC. MIO-M1 cells exposed to BIOG PCL nanofibers showed viability, and they were able to proliferate and to express GFAP, indicating cellular functionality. Moreover, nanofibers were well tolerated by CAM. These findings suggested thein vitroocular biocompatibility and absence of toxicity of these nanofibers. Finally, the BIOG nanoparticles modulated the protein adsorption, and, subsequently, ARPE-19 cells adhered and proliferated onto the nanostructured supports, establishing cell-substrate interactions. In conclusion, the biodegradable and biocompatible BIOG PCL nanofibers supported the ARPE-19 cells.

show abstract

Section: Resultsmentioning

confidence: 58%

Bioactive Glass Nanoparticles-Loaded Poly(ɛ-caprolactone) Nanofiber as Substrate for ARPE-19 Cells

Lima

Fernandes-Cunha

Jensen

et al. 2016

Journal of Nanomaterials

View full text Add to dashboard Cite

show abstract

“…The immiscibility of PCL and gelatin occurs due to the sol–gel transition, which has already been reported . Increasing the PCL content in the blend resulted in greater immiscibility demonstrated as beaded fibres from 70:30 gelatin‐to‐PCL composition which led to greater non‐homogeneity in the fibre diameter distribution .…”

Section: Resultsmentioning

confidence: 61%

“…A blend of 70:30 gelatin‐to‐PCL composition facilitated the formation of homogeneous and continuous cartilage . Kolbuk et al observed a gelatin‐to‐PCL ratio of 80:20 to be a one‐phase structure, reaching intermediate miscibility caused by the strong interactions between gelatin and PCL . Smoother fibres were obtained with the 80:20 gelatin‐to‐PCL blend in our case, and therefore it was selected as the optimized blend composition for further experimentation.…”

Section: Resultsmentioning

confidence: 71%

Electrospun microporous gelatin–polycaprolactone blend tubular scaffold as a potential vascular biomaterial

Joy

Pereira

Aid‐Launais

et al. 2019

Polymer International

View full text Add to dashboard Cite

The work reported involved the fabrication of an electrospun tubular conduit of a gelatin and polycaprolactone (PCL) blend as an adventitia-equivalent construct. Gelatin was included as the matrix for increased biocompatibility with the addition of PCL for durability. This is contrary to most of the literature available for biomaterials based on blends of gelatin and PCL where PCL is the major matrix. The work includes the assiduous selection of key electrospinning parameters to obtain smooth bead-free fibres with a narrow distribution of pore size and fibre diameter. Few reports elucidate the optimization of all electrospinning parameters to fabricate tubular conduits with a focus on obtaining homogeneous pores and fibres. This stepwise investigation would be unique for the fabrication of gelatin-PCL electrospun tubular constructs. The fabricated microfibrous gelatin-PCL constructs had pores of size ca 50-100 m reportedly conducive for cell infiltration. The measured value of surface roughness of 57.99 ± 17.4 nm is reported to be favourable for protein adhesion and cell adhesion. The elastic modulus was observed to be similar to that of the tunica adventitia of the native artery. Preliminary in vitro and in vivo biocompatibility tests suggest safe applicability as a biomaterial. Minimal cytotoxicity was observed using MTT assay. Subcutaneous implantation of the scaffold demonstrated acute inflammation which decreased by day 15. The findings of this study could enable the fabrication of smooth bead-free microfibrous gelatin-PCL tubular construct as viable biomaterial which can be included in a bilayer or a trilayer scaffold for vascular tissue engineering.

show abstract

“…The higher T g of PGSu in blends suggest changes in the mobility of oligomer chains, which might be related to good oligomer distribution [32] and/or the compatibility of both components. The T g shift of the bicomponent fibre components towards each other observed in PLLA with PGSu (PLLA10, PLLA20) indicates polar interactions and compatibility between both polymers [4,33]. Mesophase formation in bicomponent fibres with PLLA was detected with WAXS, which proves its better chain mobility due to the PGSu additive.…”

Section: Discussionmentioning

confidence: 86%

Poly(Glycerol Succinate) as an Eco-Friendly Component of PLLA and PLCL Fibres towards Medical Applications

et al. 2020

View full text Add to dashboard Cite

This study was conducted as a first step in obtaining eco-friendly fibres for medical applications using a synthesised oligomer poly(glycerol succinate) (PGSu) as an additive for synthetic poly(L-lactic acid) (PLLA) and poly (L-lactide-co-caprolactone) (PLCL). The effects of the oligomer on the structure formation, morphology, crystallisation behaviour, and mechanical properties of electrospun bicomponent fibres were investigated. Nonwovens were investigated by means of scanning electron microscopy (SEM), wide angle X-ray scattering (WAXS), differential scanning calorimetry (DSC), and mechanical testing. The molecular structure of PLLA fibres is influenced by the presence of PGSu mainly acting as an enhancer of molecular orientation. In the case of semicrystalline PLCL, chain mobility was enhanced by the presence of PGSu molecules, and the crystallinity of bicomponent fibres increased in relation to that of pure PLCL. The mechanical properties of bicomponent fibres were influenced by the level of PGSu present and the extent of crystal formation of the main component. An in vitro study conducted using L929 cells confirmed the biocompatible character of all bicomponent fibres.

show abstract

Investigations of polycaprolactone/gelatin blends in terms of their miscibility

Cited by 14 publications

References 14 publications

Bioactive Glass Nanoparticles-Loaded Poly(ɛ-caprolactone) Nanofiber as Substrate for ARPE-19 Cells

Bioactive Glass Nanoparticles-Loaded Poly(ɛ-caprolactone) Nanofiber as Substrate for ARPE-19 Cells

Electrospun microporous gelatin–polycaprolactone blend tubular scaffold as a potential vascular biomaterial

Poly(Glycerol Succinate) as an Eco-Friendly Component of PLLA and PLCL Fibres towards Medical Applications

Contact Info

Product

Resources

About