Investigations of the human aluminium biokinetics with 26Al and AMS

Kislinger, Georg; Steinhausen, C.; Alvarez-Brückmann, M.; Winklhofer, C.; Ittel, T. H.; Nolte, E.

doi:10.1016/s0168-583x(96)00624-6

Cited by 19 publications

(2 citation statements)

References 7 publications

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“…6 min), only 26 Al can be used for a study of Al retention over a reasonable time period. It has been shown that with 26 Al and AMS the radiation dose for the body can be one order of magnitude or more lower than the daily natural dose rate of radiation for measurement by AMS (Kislinger et al 1997). AMS is an invaluable tool for studying Al absorption and kinetics.…”

Section: Al As a Tracer For Bioavailabilitymentioning

confidence: 99%

“…This was done to more fully develop Al biokinetics. It was found that the sizes of the two compartments were different in patients with renal failure when compared with those of healthy volunteers (Kislinger et al 1997). In the future, compartmental modelling may yield more information than determination of bioavailability.…”

Section: Al As a Tracer For Bioavailabilitymentioning

confidence: 99%

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Use of accelerator mass spectrometry for studies in nutrition

2001

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Accelerator mass spectrometry (AMS) is an ultrasensitive analytical technique for measuring rare nuclides such as 14 C, 26 Al and 41 Ca. The low detection limit and wide dynamic range of AMS allow long-term and highly sensitive tracer studies in nutrition that cannot be performed with other methods. The present paper is intended to provide a description of AMS to the interested nutritionist and present proven applications. AMS is compared to liquid scintillation counting and stable isotope MS. A description of common AMS methodology is presented that consists of determining the dose, preparing the sample, diluting the sample (if necessary), and measuring the sample. Applications include Ca metabolism, Al uptake from the environment, dietary intake of carcinogens, fat metabolism and folate metabolism. Throughout this discussion the experimental advantages (small doses that pose no health risk, extremely long experimental lifetime, small sample sizes and high sensitivity) made possible by the unique analytical capabilities of AMS are emphasized. The future of AMS is discussed. As the number of AMS centres, instruments, and studies increases, the number of nutritional applications that employ AMS will continue to grow. The coupling of AMS with other analytical techniques (e.g. high performance liquid chromatography) will be developed as access to AMS improves.Accelerator mass spectrometry: Stable isotopes: Micronutrient metabolism: Fat metabolism: Carcinogens: Radioisotope

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Section: Al As a Tracer For Bioavailabilitymentioning

confidence: 99%

Section: Al As a Tracer For Bioavailabilitymentioning

confidence: 99%

Use of accelerator mass spectrometry for studies in nutrition

2001

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Computational approach to the blood–aluminum problem?

Exley

Beardmore

Rugg

2006

Int J of Quantum Chemistry

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ABSTRACT:Aluminum has no known function in biota and, when biologically available, is inimical to life. A key to understanding its potential toxicity in humans is its transport in blood. A consensus of opinion has identified the binding of aluminum by the iron-transport protein transferrin as the preeminent factor in the transport of aluminum in blood, although this idea has emanated from in vitro analysis of isolated blood and has never been tested in vivo. We have highlighted what we believe to be inadequacies of our present understanding of aluminum transport in blood, and we have proposed the application of computational methods to test rigorously what we have coined "the blood-aluminum problem."

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Accelerator Mass Spectrometry as a Bioanalytical Tool for Nutritional Research

Vogel

Turteltaub

1998

Advances in Experimental Medicine and Biology

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September 1997This is a preprint of a paper intended for publication in a journal or proceedings. Since changes may be made before publication, this preprint is made available with the understanding that it will not be cited or reproduced without the permission of the author. PREPRINTThis paper was prepared for submittal to the DISCLAIMER This document was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States Government nor the University of California nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise, does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States Government or the University of California. The views and opinions of authors expressed herein do not necessarily state or reflect those of the United States Government or the University of California, and shall not be used for advertising or product endorsement purposes. Accelerator Mass Spectrometry is a mass spectrometric method of detecting long-lived radioisotopes without regard to their decay products or half-life. The technique is normally applied to geochronology, but has recently been developed for bioanalytical tracing. AMS detects isotope concentrations to parts per quadrillion, quantifying labeled biochemicals to attomole levels in milligram-sized samples. Its advantages over non-isotopic and stable isotope labeling methods are reviewed and examples of analytical integrity, sensitivity, specificity, and applicability are provided.

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Investigations of the human aluminium biokinetics with 26Al and AMS

Cited by 19 publications

References 7 publications

Use of accelerator mass spectrometry for studies in nutrition

Use of accelerator mass spectrometry for studies in nutrition

Computational approach to the blood–aluminum problem?

Accelerator Mass Spectrometry as a Bioanalytical Tool for Nutritional Research

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