Investigations of the Y Chromosome, Male Founder Structure and YSTR Mutation Rates in the Old Order Amish

Pollin, Toni I.; McBride, Daniel J.; Agarwala, Richa; Schäffer, Alejandro A.; Shuldiner, Alan R.; Mitchell, Braxton D.; O’Connell, Jeffrey R.

doi:10.1159/000108941

Cited by 41 publications

(23 citation statements)

References 153 publications

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“…Familiar Amish norms like carrying out intragroup discussions in Pennsylvania Dutch, favouring horse-and-buggy over automobiles, traditional 'humble' clothing, absolute pacifism and forsaking appliances like telephones, televisions, refrigerators and indoor toilets, are means to signal this uncoupling from their broader society (Fuchs et al, 1990;Kraybill, 2001). Genealogical and genetic analysis reveals the Amish have been significantly isolated since Old-Order founding populations immigrated in the 18th and 19th centuries (Hostetler, 1993;Kraybill, 2001;Pollin et al, 2007;Hurst & McConnell, 2010;Lee et al, 2010). Arguably the Old-Order Amish are the most culturally and reproductively isolated Anabaptist group in the United States (Nolt, 1992;Hostetler, 1993;Kraybill, 2001).…”

Section: Endogamymentioning

confidence: 99%

Some Uses of Models of Quantitative Genetic Selection in Social Science

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2016

J. Biosoc. Sci.

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Summary. The theory of selection of quantitative traits is widely used in evolutionary biology, agriculture and other related fields. The fundamental model known as the breeder's equation is simple, robust over short time scales, and it is often possible to estimate plausible parameters. In this paper it is suggested that the results of this model provide useful yardsticks for the description of social traits and the evaluation of transmission models. The differences on a standard personality test between samples of Old Order Amish and Indiana rural young men from the same county and the decline of homicide in Medieval Europe are used as illustrative examples of the overall approach. It is shown that the decline of homicide is unremarkable under a threshold model while the differences between rural Amish and non-Amish young men are too large to be a plausible outcome of simple genetic selection in which assortative mating by affiliation is equivalent to truncation selection.

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Section: Endogamymentioning

confidence: 99%

Some Uses of Models of Quantitative Genetic Selection in Social Science

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Harpending

2016

J. Biosoc. Sci.

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“…To avoid close relatives, we only investigated male participants with different surnames, which were checked against pedigree information to ensure accuracy. Comparative NRY STR data for Hutterites (Pichler et al 2010), Old Order Amish (Pollin et al 2007), and eight European populations (Poland, Sweden, Netherlands, Finland, Italy, Russia, Germany, and Switzerland) were collected from the literature (Table 1).…”

Section: Population Samplesmentioning

confidence: 99%

“…Recently, anthropological genetic studies applied uniparental molecular genetic markers to examine the biological consequences of migration by the different Anabaptist populations (Pollin et al 2007;Melton et al 2010;Pichler et al 2010). These Anabaptist groups (Amish, Hutterites, and Mennonites) have experienced dynamic histories characterized by several demographic events, which have contributed to their unique genetic structure (Martin et al 1996;Crawford 2000;Melton et al 2010;Melton 2012).…”

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confidence: 99%

“…These Anabaptist groups (Amish, Hutterites, and Mennonites) have experienced dynamic histories characterized by several demographic events, which have contributed to their unique genetic structure (Martin et al 1996;Crawford 2000;Melton et al 2010;Melton 2012). However, to date few studies have focused on the paternal contribution in these Anabaptist communities by examining NRY polymorphisms (Pollin et al 2007;Pichler et al 2010). Short tandem repeat (STR) markers from the NRY are known to be informative for determining paternal genetic ancestral patterns in recently derived human populations, and examining these polymorphisms provides additional insight into their genetic history.…”

mentioning

confidence: 99%

“…Two previous studies investigated the NRY in Anabaptist communities. Pollin et al (2007) studied NRY variation in the Amish population and found a high correlation between their male genetic lineages and genealogical information based on surname analysis. Pichler et al (2010) investigated NRY variation in the Hutterite population, compared them with an Austrian population from South Tryol, and found that this population demonstrated a unique genetic profile related to central and eastern European population.…”

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confidence: 99%

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Paternal Genetic Structure in Contemporary Mennonite Communities from the American Midwest

Beaty¹,

Mosher²,

Crawford³

et al. 2016

Human Biology

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Over the last 35 years, researchers from the Laboratory of Biological Anthropology at the University of Kansas have been working with Mennonite communities to better understand evolutionary patterns of fission-fusion in relationship to their genetic history and population structure. In this study, short tandem repeat (STR) markers from the nonrecombining region of the Y chromosome (NRY) provided increased resolution of the molecular population structure for these groups. NRY is known to be informative for determining paternal genetic ancestral patterns in recently derived human populations. Mennonites represent a branch of the Anabaptist movement that began in northern and central Europe in the 16th century and maintain a well-documented migration and genealogical history. Provided this historical information, we investigated the genetic relationship of 15 NRY STR loci within five Mennonite communities from Kansas (Goessel, Lone Tree, Garden View, and Meridian) and Nebraska (Henderson). We sought to determine if patterns of fission/fusion along familial lines persisted with paternal genetic information as evidenced through other classical genetic polymorphisms and molecular markers. NRY haplotype information was obtained for 94 individuals, and genetic variation was analyzed and compared across the five study populations and comparative Anabaptist and European populations. NRY haplogroups were assigned using a Bayesian allele frequency approach with 14 STR loci. A total of 92 NRY haplotypes were detected, with none shared across these communities. The most prevalent NRY haplogroup was R1b, which occurred in 56% of the entire sample. Eight additional NRY haplogroups (E1b1b, G2a, I1, I2, J2a1, L, Q, and R1a) were detected in smaller frequencies. Principal component analysis of NRY data, in contrast to mitochondrial DNA data, displayed no patterns of population subdivision of these congregations into communities. These NRY genetic profiles provide additional information regarding the recent migratory history of Mennonite communities and additional evidence for fission along paternal lines after migration to the United States.

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Extent and distribution of linkage disequilibrium in the Old Order Amish

Hout¹,

Levin²,

Rampersaud³

et al. 2009

Genetic Epidemiology

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Knowledge of the extent and distribution of linkage disequilibrium (LD) is critical to the design and interpretation of gene mapping studies. Because the demographic history of each population varies and is often not accurately known, it is necessary to empirically evaluate LD on a population-specific basis. Here we present the first genome-wide survey of LD in the Old Order Amish (OOA) of Lancaster County Pennsylvania, a closed population derived from a modest number of founders. Specifically, we present a comparison of LD between OOA individuals and US Utah participants in the International HapMap project (abbreviated CEU) using a high-density single nucleotide polymorphism (SNP) map. Overall, the allele (and haplotype) frequency distributions and LD profiles were remarkably similar between these two populations. For example, the median absolute allele frequency difference for autosomal SNPs was 0.05, with an inter-quartile range of 0.02–0.09, and for autosomal SNPs 10–20 kb apart with common alleles (minor allele frequency≥0.05), the LD measure r2 was at least 0.8 for 15 and 14% of SNP pairs in the OOA and CEU, respectively. Moreover, tag SNPs selected from the HapMap CEU sample captured a substantial portion of the common variation in the OOA (∼88%) at r2≥0.8. These results suggest that the OOA and CEU may share similar LD profiles for other common but untyped SNPs. Thus, in the context of the common variant-common disease hypothesis, genetic variants discovered in gene mapping studies in the OOA may generalize to other populations.

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Investigations of the Y Chromosome, Male Founder Structure and YSTR Mutation Rates in the Old Order Amish

Cited by 41 publications

References 153 publications

Some Uses of Models of Quantitative Genetic Selection in Social Science

Some Uses of Models of Quantitative Genetic Selection in Social Science

Paternal Genetic Structure in Contemporary Mennonite Communities from the American Midwest

Extent and distribution of linkage disequilibrium in the Old Order Amish

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