Investigations on anti-inflammatory and analgesic activities of Alnus nitida Spach (Endl). stem bark in Sprague Dawley rats

Sajid, M.; Khan, Muhammad Rashid; Shah, Sayed Afzal; Majid, Muhammad; Ismail, Hammad; Maryam, Sonia; Batool, Riffat

doi:10.1016/j.jep.2017.01.041

Cited by 36 publications

(34 citation statements)

References 37 publications

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“…Anti-Inflammatory, Antipyretic and Analgesic Potential of Zilla spinosa in Animal Model ZSB was inactive. In present research various extract/ fractions of Z. Spinosa have shown efficient antioxidants, analgesic, anti-inflammatory effects in a concentration dependent manner similar to earlier reports (Sajid et al, 2017). Which provided further confirmation of the correlation between the antioxidant potential and biological activities that has been previously reported (Ullah et al, 2018, El-Sharabasy et al, 2013, Geronikaki et al, 2006.…”

Section: Gc Ms Analysissupporting

confidence: 92%

“…It is part of our project to investigate the whole plant and determine its biological significance. Our previous studies showed that the methanol extract and hexane fraction of Z. spinosa showed insignificant antioxidant and hepatoprotective activities (Ullah et al, 2018) and it has been previously reported that antioxidant effects translate to antiinflammatory activity (Sajid et al, 2017). Therefore, here we focused on the chloroform and butanol fractions.…”

Section: Gc Ms Analysismentioning

confidence: 99%

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Anti-Inflammatory, Antipyretic and Analgesic Potential of Zilla spinosa in Animal Model

Ullah

Shahat

Alqahtani

et al. 2019

IJAR

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The anti-inflammatory, antipyretic and analgesic activities of two concentrations (250 and 500 mg/kg) of the chloroform and butanol fractions of Zilla spinosa were determined. The carrageenan-induced rat paw edema assay was exercised for assessing the anti-inflammatory activity in rats, yeast-induced hyperthermia was utilized to assess the antipyretic activity in mice and the analgesic activity was measured by three different methods (hot-plate test model in mice, tail flick test in mice and acetic acid-induced writhing in mice). The antioxidant activity was studied by using the DPPH assay. The chloroform fraction of the methanol extract of Z. spinosa (ZSC) demonstrated the maximum inhibition of inflammation (50% at 500 mg/kg; 44% at 250 mg/kg). The chloroform fraction showed significant antipyretic activities (p andlt; 0.001 at 500 mg/kg) after 60 and 120 min of administration. ZSC also exhibited significant analgesic activity (p andlt;0.001). The butanol fraction (ZSB) was inactive in all the biological screening assays.

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Section: Gc Ms Analysissupporting

confidence: 92%

Section: Gc Ms Analysismentioning

confidence: 99%

Anti-Inflammatory, Antipyretic and Analgesic Potential of Zilla spinosa in Animal Model

Ullah

Shahat

Alqahtani

et al. 2019

IJAR

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“…In the human body, polyphenols are antioxidants, and have diverse biological properties such as anti-diabetic [7,8], anticancer [9,10], anti-inflammatory [11,12], cardioprotective [13], osteoprotective [14,15], neuroprotective [16,17], antiasthmatic [18], antihypertensive [19], antiageing [20], antiseptic [21], cerebrovascular protection [22], cholesterol lowering [23], hepatoprotective [24], antifungal [25], antibacterial [26] and antiviral properties [27] (Figure 1). …”

Section: Polyphenolsmentioning

confidence: 99%

A Critical Review on Polyphenols and Health Benefits of Black Soybeans

2017

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Polyphenols are plant secondary metabolites containing antioxidant properties, which help to protect chronic diseases from free radical damage. Dietary polyphenols are the subject of enhancing scientific interest due to their possible beneficial effects on human health. In the last two decades, there has been more interest in the potential health benefits of dietary polyphenols as antioxidant. Black soybeans (Glycine max L. Merr) are merely a black variety of soybean containing a variety of phytochemicals. These phytochemicals in black soybean (BSB) are potentially effective in human health, including cancer, diabetes, cardiovascular diseases, cerebrovascular diseases, and neurodegenerative diseases. Taking into account exploratory study, the present review aims to provide up-to-date data on health benefit of BSB, which helps to explore their therapeutic values for future clinical settings. All data of in vitro and in vivo studies of BSB and its impact on human health were collected from a library database and electronic search (Science Direct, PubMed, and Google Scholar). The different pharmacological information was gathered and orchestrated in a suitable spot on the paper.

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“…Inflammation is a protective response that produces a range of inflammatory mediators to irritation, infection, or tissue injury to eradicate the irritant or microbe and promote tissue repair ( Sherwood and Toliver-Kinsky, 2004 ; Ricciotti and FitzGerald, 2011 ; Sajid et al, 2017 ). At the same time, it can cause different degrees of injury lasting beyond the acute response such as allergic reactions, edema, effusion, and scarring.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and Analgesic Effects of Polygonum orientale L. Extracts

et al. 2017

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Background and Purpose: Polygonum orientale L. (family: Polygonaceae), named Hongcao in China, is a Traditional Chinese Medicinal and has long been used for rheumatic arthralgia and rheumatoid arthritis. However, no pharmacological and mechanism study to confirm these clinic effects have been published. In this investigation, the anti-inflammatory, analgesic effects and representative active ingredient compounds of P. orientale have been studied.Methods: Dried small pieces of the stems and leaves of P. orientale were decocted with water and partitioned successively to obtain ethyl acetate and ethyl ether extract of P. orientale (POEa and POEe). Chemical compositions of them were analyzed by UPLC-Q-Exactive HRMS. Anti-inflammatory and analgesic effects of POEa and POEe were evaluated using xylene induced ear edema, carrageenan induced paw edema, Freunds’ complete adjuvant induced arthritis, and formaldehyde induced pain in rat. Their mechanisms of anti-inflammatory and analgesic effects were also studied via assays of TNF-α, IL-1β, IL-6, and PGE2 in serum.Results: UPLC-Q-Exactive HRMS analysis showed that POEa and POEe mainly contained flavonoids including orientin, isoorientin, vitexin, luteolin, and quercetin. Furthermore, anti-inflammatory effects of POEa and POEe were evident in xylene induced ear edema. The paw edema in Freund’s complete adjuvant and carrageenan were significantly (P < 0.05, 0.01) inhibited by POEa (5, 7.5 g/kg). POEe (7.5 g/kg) was significantly (P < 0.05, 0.01) inhibited Freunds’ complete adjuvant induced paw edema and cotton pellet induced granuloma formation. Similarly, POEe significantly (P < 0.05, 0.01) inhibited the pain sensation in acetic acid induced writhing test. POEa (5, 7.5 g/kg) significantly (P < 0.05, 0.01) inhibited formaldehyde induced pain in both phases. POEa (7.5 g/kg) markedly (P < 0.05) prolonged the latency period of hot plate test after 30 and 60 min. The concentrations of TNF-α, IL-1β, IL-6, and PGE2 were significantly (P < 0.01) decreased by POEa (3.75, 5 g/kg).Conclusion: POEa and POEe have anti-inflammatory and analgesic effects, which was mainly relevant to the presence of flavonoids, including orientin, isoorientin, vitexin, luteolin, and quercetin. The mechanism of anti-inflammatory and analgesic effects of POEa may be to decrease the concentrations of TNF-α, IL-1β, IL-6, and PGE2 in serum.

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Investigations on anti-inflammatory and analgesic activities of Alnus nitida Spach (Endl). stem bark in Sprague Dawley rats

Cited by 36 publications

References 37 publications

Anti-Inflammatory, Antipyretic and Analgesic Potential of Zilla spinosa in Animal Model

Anti-Inflammatory, Antipyretic and Analgesic Potential of Zilla spinosa in Animal Model

A Critical Review on Polyphenols and Health Benefits of Black Soybeans

Anti-inflammatory and Analgesic Effects of Polygonum orientale L. Extracts

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