Investigations on blood and cerebrospinal fluid lymphocytes in patients suffering from tick-borne encephalitis

Abstract

This paper deals with the immuno-pathological characteristics of tick-borne encephalitis. With the appearance of neurological signs, there is a strong T cell reaction in th peripheral blood. The following seven days are characterized by the appearance of specific cell-mediated reaction in the peripheral blood; in the cell-mediated reaction in the peripheral blood; in the cerebrospinal fluid, an increasing number of B cells and specific antibodies can be detected. After a week, the percent positivity of cell-mediated immune reactions is higher and there is a T cell dominance in the cerebrospinal fluid. Intact cellular immunity against specific antigen is required for the management of this disease. There are major differences in the results obtained from patients suffering from meningitis alone and those suffering from meningoencephalitis.

Flow cytometric analysis of lymphocytes in cerebrospinal fluid in patients with tick-borne encephalitis

“…HLA-DR molecules, IL-2 receptors (alfa subunit-CD25+) and transferrin receptors (CD71+) are generally accepted as markers of T cell activation and the expression of these molecules plays an Tomaiit & Ihan important role in T cell functions (11,12). It is not known whether there are differences in lymphocyte subsets and their activities in various types of infection (13,14).…”

Συμβολη Στη Μελετη Της Κρωτογενους Εγκεφαλιτιδας Στην Ελλαδα

“…Τα αιματολογικά ευρήματα στη πρώτη φάση της νόσου και στο μεσοδιάστημα περι λαμβάνουν λευκοπενία, που στη δεύτερη φάση αντιστρέφεται σε λευκοκυττάρωση (6,600-14,600 λευκοκύτταρα/μΐ). Τα λεμφοκύτταρα φτάνουν τα 5,000/μ1 και η ταχύτητα καθίζησης τα 100 mm την πρώτη ώρα Οι δείκτες αυτοί επανέρχονται στις φυσιολογικές τιμές μετά τέσσερις έως έξι εβδομάδες (Sipos et al 1981).…”