Investigations on cephalosporin C adsorption kinetics and equilibria

Abstract

The kinetics and equilibria of cephalosporin C adsorption on different commercial adsorbents were investigated. Adsorption isotherms could be analysed according to the Brunauer, Emmett and Teller theory. For the interpretation of adsorption kinetics it was necessary to develop a more complex model comprising both a rapid and a slower step. An integrated approach combining kinetics and equilibria allowed for simulation of the experimental data and can be used as a basis for predicting technical approaches such as fluidized-bed technology.

Functionalized Adsorbents for the Purification of Cephalosporin C and Deacetylcephalosporin C

“…Early works reported different types of adsorbents for the isolation of CP-C, for example, activated carbons, polystyrene-based macroreticular hydrophobic resins, , or ion exchangers . More recently, divinylbenzene−styrene-based macroreticular hydrophobic resins, such as Amberlite XAD-2 and XAD-4 , or Amberlite XAD-1180, have been found to achieve better performance, although the efficiency and selectivity for the separation of CP-C and dCP-C, when tested, was not entirely satisfactory.…”