Investigations on Epidemiology and Prophylaxis of Nosocomial Infections in Intensive Care Units

Comparative Pharmacokinetics of Berberine After Oral Administration of Pure Berberine, Coptidis Rhizoma Extract, and Decoctions of Two Different Complex Herbal Formulas to Rats

“…Coptidis Rhizoma, a key herbal ingredient in both SGMX and WHW, has been widely used for centuries to treat dysentery, hypertension, inflammation, and liver diseases. 14,15 Berberine, an isoquinoline alkaloid that is the main active ingredient of Coptidis Rhizoma, has multiple bioactivities, including immunosuppressive, 16 anti-diarrheal, 17 anti-neoplastic, 18 antiinflammatory, 19 anti-arrhythmic, 20 anti-proliferative, 21 and anti-biotic 22 properties. The pharmacokinetics of berberine in plasma, bile, and urine, as well as in the tissues of mice, rats, dogs, rabbits, and humans have been reported using UV spectrophotometry, fluorometry, tritium-labeled berberine, and high-performance liquid chromatography (HPLC)-MS/ MS methods.…”