Investigations on Nucleation and Growth Kinetics of Urea Crystals from Methanol

Boomadevi, Shanmugam; Dhanasekaran, R.; Ramasamy, P.

doi:10.1002/1521-4079(200202)37:2/3<159::aid-crat159>3.0.co;2-y

Cited by 55 publications

(19 citation statements)

References 8 publications

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“…The induction time t ind is the sum of the relaxation time at which the system reaches quasi‐stable molecular clustering, the time taken to form a stable nucleus, and the time taken for the critical nucleus to grow to a detectable size . The induction period was deduced as follows.…”

Section: Methodsmentioning

confidence: 99%

Determination of Nucleation Kinetics of Cephradine in 0.5% Sodium Bisulfate (W/V) Solution

Sun

Jiang

Liu

2017

Crystal Research and Technology

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The metastable zone width of cephradine in a 0.5% sodium bisulfate (W/V) solution was determined at different values of pH and temperatures by using dynamic laser monitoring under atmospheric pressure. As the pH increased, the metastable zone width of cephradine decreased before increasing, with a minimum value at the isoelectric point. The effect of temperature was less pronounced. The induction periods of cephradine in the 0.5% sodium bisulfate (W/V) solution were investigated as a function of the supersaturation ratio. By applying classical homogeneous nucleation theory, we deduced the crystal-liquid interfacial tension and the following fundamental nucleation parameters: the Gibbs free energy change for the formation of the critical nucleus, the radius of the critical nucleus, and the number of molecules in the critical nucleus.

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Section: Methodsmentioning

confidence: 99%

Determination of Nucleation Kinetics of Cephradine in 0.5% Sodium Bisulfate (W/V) Solution

Sun

Jiang

Liu

2017

Crystal Research and Technology

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“…Nucleation and growth determination by concentration measurement: In studying the nucleation rate, the induction period is an important parameter to obtain. The induction period is commonly determined by visual confirmation of crystal appearance, such as eye [26], focused beam reflectance measurement [28], and turbidimeter [29][30][31]. Another method is by indirectly measuring the concentration change in the solution over time.…”

Section: Theorymentioning

confidence: 99%

Co-Crystallization Kinetics of 2:1 Benzoic Acid–Sodium Benzoate Co-Crystal: The Effect of Templating Molecules in a Solution

2021

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The addition of dissolved templating molecules in crystallization will create “supramolecular assemblies” within the solution, serving as “anchor points” for the solute molecules to nucleate and grow. In this work, nucleation and crystal growth kinetics of 2:1 benzoic acid (HBz)–sodium benzoate (NaBz) co-crystallization with or without templates in a solution were analyzed by monitoring the concentration of the mother liquor during cooling crystallization. The results showed that the addition of the dissolved 2:1 or 1:1 HBz–NaBz co-crystals as templating molecules could reduce the critical free energy barrier of 2:1 HBz–NaBz co-crystal during its nucleation, but did not significantly affect the order of crystal growth rate. On the other hand, the critical free energy barrier of the nucleation process was increased if dissolved NaBz was used as a templating molecule, while a significant rise in the order of crystal growth rate occurred. The crystal habit obtained from the NaBz-templated system was needle-like, suggesting that sodium–sodium coordination chains of NaBz supramolecular assemblies in the solution phase were responsible for creating elongated crystals. Conversely, a large prismatic crystal habit found in non-templated and 2:1 and 1:1 HBz–NaBz co-crystal-templated systems implied that those templating molecules formed sparsely interconnected supramolecular assemblies in the solution phase.

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“…By using the interfacial tension the radius of critical nuclei (r * ), change in Gibbs free energy (∆G * ), the number of molecules present in the nucleus (i * ) and nucleation rate (J) have been evaluated as the super-saturation increases the change in Gibbs free energy (∆G * ), the number of molecules present in the nucleus (i * ) and nucleation rate (J) decreases [23][24][25][26][27]. The interfacial tension which was calculated experimentally from the measured induction period values and compared with the amino acid based piperazinium values ( Table-1).…”

Section: Metastable Zone Widthmentioning

confidence: 99%

Growth, Nucleation Kinetics and Structural Studies on L-Valine Piperazinium Single Crystals

Arunkumar

Anburaj²

2019

Asian J. Chem.

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A single crystal of L-valine piperazinium was grown by slow growth technique. Structural studies confirm the monoclinic structure with space group P21. The solubility curve showing high soluble in water and peak shows positive solubility nature. A tiny nucleation formed at 10 ºC for room temperature process and it gradually increasing with respect process temperature. Induction period revels that time period for nucleation at constant temperature and it absorbed that in (10 ºC) 500 s for room temperature. The calculated interfacial tension values are greater than one order other amino acid based piperazinium. By using growth parameters bulk L-valine piperazinium crystal were harvested and single crystal XRD confirms that formation of L-valine piperazinium crystals.

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Investigations on Nucleation and Growth Kinetics of Urea Crystals from Methanol

Cited by 55 publications

References 8 publications

Determination of Nucleation Kinetics of Cephradine in 0.5% Sodium Bisulfate (W/V) Solution

Determination of Nucleation Kinetics of Cephradine in 0.5% Sodium Bisulfate (W/V) Solution

Co-Crystallization Kinetics of 2:1 Benzoic Acid–Sodium Benzoate Co-Crystal: The Effect of Templating Molecules in a Solution

Growth, Nucleation Kinetics and Structural Studies on L-Valine Piperazinium Single Crystals

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