Investigations on Steroids. XVI. Acetylation Studies on 3β, 5-Dihydroxy-14-ISO-17-ISO-21-Norpregnane-19,20-Dioic Acid and its Ethyl Esters

Abstract

The conversion of strophanthidin into 19-norprogesterone and 19-nor-lldesoxycorticosterone was reported from this laboratory in 1944 (l).2 Both products were amorphous. It was assumed that they were mixtures of stereoisomers, the isomerism involving in particular carbon atom 10. In analogy to conclusions drawn by Swiss investigators on structurally related compounds, carbon atoms 14 and 17 were tentatively assigned the iso-configurations (3). The 19-norprogesterone was found to possess high progestational activity (4).