Investigations on the antinociceptive activity of crude extracts from Croton cajucara leaves in mice

Chemical composition of essential oil from the bark of Croton cajucara Bentham

“…For the quantification of the components we used the data from new injections with a flame ionization detector (GC-FID), with an identical capillary column, under the same heating conditions, the carrier gas flow etc, previously defined in experiments GC-MS, with the reinjection of the series of n-alkanes and a new determination of KI for comparison with those obtained previously (ADAMS, 1995;CAZES;DEKKER, 2005).…”

“…The species Croton cajucara Bentham, popularly known as sacaca or cajuçara, is a medicinal plant commonly distributed in the Amazon region, in the form of a large shrub up to 6 m high (HIRUMA-LIMA et al, 2002a). In folk medicine the leaves and stem bark of this species are used as tea for treating diabetes, controlling high blood cholesterol, liver and gastrointestinal disorders (CAMPOS et al, 2002). A decoction of the leaves is also used against stomach pains, fever, liver problems, jaundice and malaria, whereas the infusion of the leaves mixed with melão-de-são-caetano (Momordica charantia), is useful against hepatitis HIRUMA-LIMA et al, 2002a).…”

“…Several techniques can be employed in the extraction of essential oils, such as hydrodistillation, steam distillation by drag of water, extraction with organic solvents or CO 2 liquid. Among the factors that interfere with chemical and organoleptic characteristics of essential oils, the extraction process is one of the most important; being the distillation with water steam the most used conventional process (FRIZZO et al, 2001;SILVA et al, 2005;SILVIA et al, 2002).…”

“…As these are volatile enough, the sample can be solubilized in solvents such as hexane, before being injected into the equipment without requiring derivatization steps. For separation, generally are used capillary columns suitable for separating the various components of the sample in question (CHAAR et al, 2003;SILVA et al, 2005;SIMÕES;SPITZER, 2003).…”

“…These indices allow better comparison of data between different laboratories and are calculated by the following formula (CAZES; DEKKER, 2005). This paper reports the identification of the chemical constituents of C. cajucara bark essential oils, obtained by hydrodistillation and steam drag, by gas chromatography (GC) and gas chromatography mass spectrometry (GC-MS)…”