Investigations on the role of edge activator upon structural transitions in Span vesicles

Rathod, Sachin; Arya, Shristi; Shukla, Rahul; Ray, Debes; Aswal, Vinod K.; Bahadur, Pratap; Tiwari, Sanjay

doi:10.1016/j.colsurfa.2021.127246

Cited by 16 publications

(4 citation statements)

References 38 publications

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“…The mechanisms of drug delivery are not fully understood. However, the following hypotheses explain that spanlastic contains EA, which provides flexibility and fluidizes the vesicle bilayer, which flows inside the skin, tissue, and organs, and thus enhances penetration (Fahmy et al, 2018; Rathod et al, 2021). The elastic nature of a vesicle helps it to squeeze through a skin pore, penetrate into the skin layer, and remain in shape for a prolonged period of time, which facilitated drug release in deeper layers (Chen et al, 2018; Kakkar & Kaur, 2011; Mishra et al, 2007; Zheng et al, 2020).…”

Section: The Effects Of Edge Activator On the Vesicular System And Th...mentioning

confidence: 99%

The effect of edge activator on the evolution and application of a nonionic surfactant: The elastic vesicular system

Sarolia

Baldha

Chakraborthy

et al. 2023

J Surfact & Detergents

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Vesicular drug delivery as part of the colloidal system was evolved to entrap a hydrophobic drug as well as a hydrophilic drug. The tremendous potential of this system lies in ensuring the targeted and controlled release of the drug molecules to reduce the toxicity and side effects. Liposomes and niosomes are the first duos of the vesicular system to be used in the pharmaceutical and cosmetic fields. However, the lack of elasticity in this formulation prevents its success on the market. To overcome the obstacles, additional formulation changes were made to the existing vesicle. These modifications were attributed to the one component termed edge activator (EA), which added an elasticity factor to the vesicle system. Based on the formulation and EA, the vesicular system transits in the liposome to the spanlastic system. Spanlastics are surfactant‐based nanovesicles that are elastic, malleable, and given that it is a vesicular system with polar and nonpolar components, it can retain both hydrophilic and lipophilic medications. A modified method of medication delivery may also be possible. This review article discusses the recent approaches to the evolution of nonionic surfactant vesicular systems with respect to their method of preparation, effects of EA, and therapeutic application of spanlastic.

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Section: The Effects Of Edge Activator On the Vesicular System And Th...mentioning

confidence: 99%

The effect of edge activator on the evolution and application of a nonionic surfactant: The elastic vesicular system

Sarolia

Baldha

Chakraborthy

et al. 2023

J Surfact & Detergents

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“…Despite this, these nanocarriers can be rejected due to their rigidity. Notably, a flexible bilayer facilitates the passage of vesicles through biological membranes and eliminates the true cause of ineffectual ocular delivery (i.e., the dense mucin layer) ( Kaviarasi et al, 2023 ; Rathod et al, 2021 ). Vesicular drug delivery systems are an intriguing strategy for attaining desirable ocular delivery system characteristics such as simplicity of administration, targeted and controlled drug delivery, and exceptional permeability.…”

Section: Introductionmentioning

confidence: 99%

Formulation, optimization and evaluation of ocular gel containing nebivolol Hcl-loaded ultradeformable spanlastics nanovesicles: In vitro and in vivo studies

Yasser,

El Naggar,

Elfar

et al. 2024

International Journal of Pharmaceutics: X

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“…Besides that, the vesicle also act as penetration enhancer, increase penetration through fusion or adsorption with the stratum corneum, and through the hair follicle. The addition of an edge activator also increases skin diffusion by increasing the vesicle capacity to bind water, preventing water evaporation, and hydrating the skin enhancing its suitability to be applied on the skin for topical uses (Alaaeldin et al, 2021;Rathod et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Characterization of Spanlastic System Loaded Green Tea Extract as Antioxidant for Skin

Santuso

Soeratri

Purwanti

2023

JFIKI

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Background: Green tea possesses abundant polyphenols that exert antioxidant activity. However, green tea’s hydrophilicity and instability limit its penetration into the skin layers. Recently, a non-ionic surfactant-based elastic nanovesicular system called spanlastic can enhance the delivery of hydrophilic and unstable substances. Spanlastic composed of vesicle builder and edge activator, which influence the characteristics of the vesicle. Objective: The study aimed to evaluate the influence of the ratio of the components on the characterization of green tea extract-loaded spanlastic using three different weight ratio of vesicle builder and edge activator that is 7:3, 8:2, and 9:1. Methods: Spanlastic is prepared by ethanol injection methods using Span 60 as vesicle builder (VB) and Tween® 60 as edge activator (EA). The characterization includes visually observed organoleptic, particle size (PS) and polydispersity index (PDI) using dynamic light scattering, entrapment efficiency (EE) and drug loading (DL) using total phenolic content assay. The most optimum ratio will be tested its zeta potential value using Zetasizer and viscosity using Brookfield Cone and Plate. Results: Selected spanlastic formula composed of Span 60 and Tween® 60 at a weight ratio of 8:2 has given characteristics as follows: entrapment efficiency 60.85±1.70%; drug loading 11.07±0.65%; the particle size is 419.70±7.42 nm; and PDI value 0.26±0.05. The prepared spanlastic has a greenish liquid form, with a zeta potential value of 28.53±2.78 mV and viscosity of 14.65±0.32 cP. Conclusion: The optimum weight ratio of vesicle builder and edge activator for green tea extract spanlastic is Span 60:Tween® 60 8:2.

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Investigations on the role of edge activator upon structural transitions in Span vesicles

Cited by 16 publications

References 38 publications

The effect of edge activator on the evolution and application of a nonionic surfactant: The elastic vesicular system

The effect of edge activator on the evolution and application of a nonionic surfactant: The elastic vesicular system

Formulation, optimization and evaluation of ocular gel containing nebivolol Hcl-loaded ultradeformable spanlastics nanovesicles: In vitro and in vivo studies

Characterization of Spanlastic System Loaded Green Tea Extract as Antioxidant for Skin

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