Investigations to characterize a new antiarrhythmic drug bisaramil

Bisaramil, A New Class I Antiarrhythmic Agent

“…The force and rate of contraction of spontaneously beating guinea pig right atria were equally decreased by bisaramil at concentrations less than 10 r;LM and its negative inotropic effects became prominent above 10 pA4 (10). Like verapamil, bisaramil caused a parallel shift of the dose-response curve for CaC1,-induced contractions of the left atria of guinea pigs (10). These results suggest a depressant action by bisaramil on the L-type Ca2" current (1 1,15).…”

“…Like verapamil, bisaramil caused a parallel shift of the dose-response curve for CaC1,-induced contractions of the left atria of guinea pigs (10). These results suggest a depressant action by bisaramil on the L-type Ca2" current (1 1,15).…”

“…Bisaramil had local anesthetic effects on frog sciatic nerve with nearly equal potency to lidocaine and was more potent than either propranolol or quinidine (10). The drug had no p blocking action as judged by the absence of an effect on isoproterenol-induced heart rate increase in cats (10).…”

“…Corrected sinus node recovery time was also prolonged by bisaramil. Its duration of action did not exceed 30 min (10). decreased blood pressure, cardiac output, and cardiac work ( 5 ) .…”

“…The drug had no p blocking action as judged by the absence of an effect on isoproterenol-induced heart rate increase in cats (10).…”