Investigations toxicologiques sur une couche

Bromazepam intoxication in an infant: Contribution of hair and nail analysis

“…The last interesting point is the use of diapers as an alternative matrix. This has already been described in a first case for paracetamol, alcohols, and formate ions and was confirmed in the present case when bromazepam was identified in two samples taken from a diaper. In the absence of urine at day 10, no quantitative comparison is possible, but our result confirms that this matrix can be used to identify molecules when urine sampling is very difficult or impossible, particularly in infants or incontinent patients.…”

“…The samples analyzed at the Institute of Forensic Toxicology are summarized in Table (at the request of the magistrate, bromazepam was confirmed again in blood and urine). Bromazepam was measured in the various samples by UPLC–MS/MS (Xevo TQD, Waters, France) according to previously published methods . The hair samples were analyzed after decontamination and segmentation if required, followed by incubation at pH 9.5.…”

“…Bromazepam was measured in the various samples by UPLC-MS/MS (Xevo TQD, Waters, France) according to previously published methods. 3,4 The hair samples were analyzed after decontamination and segmentation if required, followed by incubation at pH 9.5. The lock of the infant's hair (2 cm) was analyzed without segmentation.…”