Investigative Studies with the Skin Coloring Agents Dihydroxyacetone and Glyoxal

Goldman, Leon; Barkoff, J R; Blaney, Donald J.; Nakai, Takashi; Suskind, Raymond R.

doi:10.1038/jid.1960.100

Cited by 30 publications

(15 citation statements)

References 1 publication

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“…17 In the 1950s, researchers at the University of Cincinnati Children's Hospital began studying its use as a tolerance test for glycogen storage disease. 18 Characteristic pigmentation changes were observed in children who inadvertently regurgitated and exposed their skin to test material, leading to the identification of DHA as a tanning agent.…”

Section: Dihydroxyacetonementioning

confidence: 98%

Sunless tanning

Dusza

Halpern

2004

Journal of the American Academy of Dermatology

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Section: Dihydroxyacetonementioning

confidence: 98%

Sunless tanning

Dusza

Halpern

2004

Journal of the American Academy of Dermatology

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“…The experi ment involved a transmission study of monochromatic wavelengths of UV through keratin sheets which had been treated with DHA, naphthoquinone, or both. The results of that study [15] erroneously reinforced old concepts that DHA-treated skin did not have increased resistance to UV light [1,5,6,10].…”

Section: Discussionmentioning

confidence: 63%

Protection against Long Ultraviolet and/or Visible Light with Topical Dihydroxyacetone

Fusaro¹,

Johnson²

1975

Dermatology

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Dihydroxyacetone (DHA) chemically induces long ultraviolet (UV) and/or visible photoprotection into the stratum corneum as demonstrated by (a) long UV protection of albino rats which were psoralen-photosensitized to black fluorescent light and (b) sunlight protection of five patients with long UV and/or visible photosensitivity. Previously, DHA treatment of skin was considered to provide no protection against UV. For clinical use, the combination of DHA and lawsone (2-hydroxy-1,4-naphthoquinone) is preferred to DHA alone, because it provides rapid, positive protection over a range extending from short UV into the visible region of sunlight.

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“…Eva Wittgenstein noticed that when children accidentally “spit up” an orally administered solution of DHA onto their skin, pigmentation occurred. 69 While it had been previously known that sugars react with primary amines to form brown pigments known as melanoidins, a reaction discovered by Maillard in 1912, 70 and more mechanistically detailed by Hodge in 1953, 71 it was Wittgenstein and Berry who drew a connection between the browning in foods and the browning of skin from DHA. 72 They suggested that the mechanism through which DHA functions as an artificial tanning lotion is a reaction between the carbonyl group of DHA and the basic groups of amino acids in proteins present on the surface of the skin.…”

Section: Dihydroxyacetone Synthonsmentioning

confidence: 99%

Synthetic Biomaterials from Metabolically Derived Synthons

et al. 2016

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The utility of metabolic synthons as the building blocks for new biomaterials is based on the early application and success of hydroxy acid based polyesters as degradable sutures and controlled drug delivery matrices. The sheer number of potential monomers derived from the metabolome (e.g., lactic acid, dihydroxyacetone, glycerol, fumarate) gives rise to almost limitless biomaterial structural possibilities, functionality, and performance characteristics, as well as opportunities for the synthesis of new polymers. This review describes recent advances in new chemistries, as well as the inventive use of traditional chemistries, toward the design and synthesis of new polymers. Specific polymeric biomaterials can be prepared for use in varied medical applications (e.g., drug delivery, tissue engineering, wound repair, etc.) through judicious selection of the monomer and backbone linkage.

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Investigative Studies with the Skin Coloring Agents Dihydroxyacetone and Glyoxal

Cited by 30 publications

References 1 publication

Sunless tanning

Sunless tanning

Protection against Long Ultraviolet and/or Visible Light with Topical Dihydroxyacetone

Synthetic Biomaterials from Metabolically Derived Synthons

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