Investing in Late-Life Brain Capital

Dawson, Walter D.; Smith, Erin M.; Booi, Laura; Mosse, Maia A.; Lavretsky, Helen; Reynolds, Charles F.; Cummings, Jeffrey L.; Brannally, Patrick; Hynes, William; Lenze, Eric J.; Manes, Facundo; Ayadi, Rym; Frank, Lori; Chapman, Sandra B.; Robertson, Ian H.; Rubenstein, Lori; Jraissati, Jorge; Ibáñez, Agustín; Fillit, Howard; Jeste, Dilip V.; Rao, Anitha; Berk, Michael; Storch, Eric A.; Chadha, Antonella Santuccione; Eyre, Harris A.

doi:10.1093/geroni/igac016

Cited by 9 publications

(7 citation statements)

References 7 publications

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“…Together with the OECD the WBP is demonstrating the importance of building and protecting our own brain health, which we call “late-life Brain Capital.” We have argued that investing in late-life Brain Capital can help older persons retain, engage, and empower themselves ( Dawson et al, 2022 ). A combination of public health strategies targeting tobacco use, blood pressure control, cardiovascular disease management and prevention, among others, can reduce the likelihood of cognitive decline by making an investment in late-life brain capital.…”

Section: Sex and Gender Policy Framework In Alzheimer’s Diseasementioning

confidence: 99%

Sex and gender considerations in Alzheimer’s disease: The Women’s Brain Project contribution

Castro-Aldrete

Moser

Putignano

et al. 2023

Front. Aging Neurosci.

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The global population is expected to have about 131.5 million people living with Alzheimer’s disease (AD) and other dementias by 2050, posing a severe health crisis. Dementia is a progressive neurodegenerative condition that gradually impairs physical and cognitive functions. Dementia has a variety of causes, symptoms, and heterogeneity concerning the influence of sex on prevalence, risk factors, and outcomes. The proportion of male-to-female prevalence varies based on the type of dementia. Despite some types of dementia being more common in men, women have a greater lifetime risk of developing dementia. AD is the most common form of dementia in which approximately two-thirds of the affected persons are women. Profound sex and gender differences in physiology and pharmacokinetic and pharmacodynamic interactions have increasingly been identified. As a result, new approaches to dementia diagnosis, care, and patient journeys should be considered. In the heart of a rapidly aging worldwide population, the Women’s Brain Project (WBP) was born from the necessity to address the sex and gender gap in AD. WBP is now a well-established international non-profit organization with a global multidisciplinary team of experts studying sex and gender determinants in the brain and mental health. WBP works with different stakeholders worldwide to help change perceptions and reduce sex biases in clinical and preclinical research and policy frameworks. With its strong female leadership, WBP is an example of the importance of female professionals’ work in the field of dementia research. WBP-led peer-reviewed papers, articles, books, lectures, and various initiatives in the policy and advocacy space have profoundly impacted the community and driven global discussion. WBP is now in the initial phases of establishing the world’s first Sex and Gender Precision Medicine Institute. This review highlights the contributions of the WBP team to the field of AD. This review aims to increase awareness of potentially important aspects of basic science, clinical outcomes, digital health, policy framework and provide the research community with potential challenges and research suggestions to leverage sex and gender differences. Finally, at the end of the review, we briefly touch upon our progress and contribution toward sex and gender inclusion beyond Alzheimer’s disease.

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Section: Sex and Gender Policy Framework In Alzheimer’s Diseasementioning

confidence: 99%

Sex and gender considerations in Alzheimer’s disease: The Women’s Brain Project contribution

Castro-Aldrete

Moser

Putignano

et al. 2023

Front. Aging Neurosci.

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“…In today's interdependent world, prioritizing and improving brain health becomes a vital goal in advancing the collective health of populations across the globe (1,2). The term "brain health" is not a standardized one.…”

Section: Introductionmentioning

confidence: 99%

Empathy as a crucial skill in disrupting disparities in global brain health

Fitri,

Lage,

Mollayeva

et al. 2023

Front. Neurol.

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Brain health refers to the state of a person’s brain function across various domains, including cognitive, behavioral and motor functions. Healthy brains are associated with better individual health, increased creativity, and enhanced productivity. A person’s brain health is intricately connected to personal, social and environmental factors. Racial, ethnic, and social disparities affect brain health and on the global scale these disparities within and between regions present a hurdle to brain health. To overcome global disparities, greater collaboration between practitioners and healthcare providers and the people they serve is essential. This requires cultural humility driven by empathy. Empathy is a core prosocial value, a cognitive-emotional skill that helps us understand ourselves and others. This position paper aims to provide an overview of the vital roles of empathy, cooperation, and interdisciplinary partnerships. By consciously integrating this understanding in practice, leaders can better position themselves to address the diverse challenges faced by communities, promote inclusivity in policies and practices, and further more equitable solutions to the problem of global brain health.

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“…An open innovation ecosystem, based on the co-creation of citizen and policy labs with scalable digital healthcare solutions, a rapid-learning culture, change implementation, and co-creation are unique tools provided by brain capital initiatives. 5 These innovative approaches may not only impact health but represent a holistic investment in the future of the country’s brain capital. We strongly encourage the development of these models across multiple scales in Brazil and Latin America.…”

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confidence: 99%