The North Singhbhum Mobile Belt (NSMB) in the eastern Indian shield is an excellent example of a diverse lithological domain with multiphase shear/fracture zones. It is a well-acknowledged prospective region known for various mineralizations, e.g., Cu, Au, U, and Fe. The present study was conducted in the Babaikundi–Birgaon Axis (a shear and fracture zone within NSMB) within Babaikundi village. The study suggests that anomalous zones are possibly related to gold-associated sulfide mineralization using photomicrography and geophysical methods such as magnetic, self-potential (SP), and very low-frequency (VLF) electromagnetic (EM) methods. Photomicrography on quartz samples and Scanning Electron Microscope (SEM) Backscattered-Electron (BSE) images show that gold particles are present in the quartz reef vein in Babaikundi. Magnetic data are presented in the total magnetic intensity (TMI), upward continuation, and analytical signal maps. VLF-EM data were analyzed using different processing techniques to delineate anomalous auriferous zones. Furthermore, the SP data were inverted using the Particle Swarm Optimization (PSO), Very Fast Simulated Annealing (VFSA), and Genetic Algorithm (GA) approaches for comparative study of the resultant model parameters and their suitability considering a 2D inverted resistivity section derived using VLF-EM. The photomicrography study indicates the existence of gold/ pyrite/pyrrhotite within the Babaikundi–Birgaon axis, which corresponds to a low magnetic anomaly based on a magnetic study; a high current density, a high Fraser value, and a low resistivity based on the VLF-EM study; and a negative SP value was found based on the SP study. The combined study generally supports mapping auriferous zones and demarcates the Babaikundi–Birgaon axis within the Babaikundi–Birgaon area.