Invisible mycosis fungoides: A diagnostic challenge

Gallardo, Fernando; Llistosella, E; Blanco, Aurora; Bernadób, Lluís; Bordés, R; Nomdedeu, Josep; Servitje, Octavio

doi:10.1016/s0190-9622(00)90103-8

Cited by 46 publications

(31 citation statements)

References 20 publications

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“…In that context, one might consider the rare entity of invisible MF, which is known to be a diagnostic challenge because of the presence of histopathologic findings in the absence of clinically suspicious lesions. 23 As discussed previously, the submission of acrochordons for histopathologic evaluation is a point of contention with supporters of histopathologic evaluation reporting cases of clinically atypical acrochordons being involved by malignancies. We believe our case provides further evidence supporting microscopic examination of clinical acrochordons, especially if clinical features of atypia are present or the patient has a history of a cutaneous or noncutaneous malignancy.…”

Section: Discussionmentioning

confidence: 98%

Mycosis fungoides involving an acrochordon: a case report

et al. 2012

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We present the case of a 77-year-old male undergoing treatment for mycosis fungoides (MF) who presented for removal of an acrochordon on his mid back. Histopathologic examination of the acrochordon revealed a dense, band-like lymphocytic inflammatory infiltrate in the dermis with epidermotropism of single lymphocytes and small nests of lymphocytes into the lower epidermis. Immunohistochemical staining characterized the dermal and epidermal lymphocytic population as CD3-positive T lymphocytes with a predominance of CD4-positive over CD8-positive lymphocytes. These findings were consistent with the patient's known MF and molecular identification of a clonal T-cell receptor gene rearrangement further supported the diagnosis. Our unusual case reports MF involving an acrochordon and provides evidence to support the importance of submitting acrochordons for histopathologic examination.

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Section: Discussionmentioning

confidence: 98%

Mycosis fungoides involving an acrochordon: a case report

et al. 2012

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“…skin signs. 3,4 So far, there is no definite clinical classification of different forms of pruritus. Although new approaches have been undertaken, no system yet proposed fulfils all clinical and pathophysiological needs.…”

Section: Discussionmentioning

confidence: 99%

Pruritus as a leading symptom: clinical characteristics and quality of life in German and Ugandan patients

Weißhaar

Apfelbacher

Jäger

et al. 2006

British Journal of Dermatology

158

127

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“…49-55 The latter is related to skin with a normal appearance which shows, on histopathology, immunophenotype and electron microscopy, evidence of infiltration by monoclonal and atypical lymphocytes. In general, these patients show classic or suggestive lesions of MF that are referred to as "invisible" MF lesions due to their normal appearance on clinical examination, and sometimes as "invisible" MF for corresponding to the hypochromiant MF present in patients with very fair skin and, therefore, "identical" to normal skin.…”

Section: Mycosis Fungoides: Clinical/histological Variants Described mentioning

confidence: 99%

“…In general, these patients show classic or suggestive lesions of MF that are referred to as "invisible" MF lesions due to their normal appearance on clinical examination, and sometimes as "invisible" MF for corresponding to the hypochromiant MF present in patients with very fair skin and, therefore, "identical" to normal skin. 54,55 …”

Section: Mycosis Fungoides: Clinical/histological Variants Described mentioning

confidence: 99%

Mycosis fungoides and Sézary syndrome: clinical, histopathological and immunohistochemical review and update

Yamashita

Abbade

Marques

et al. 2012

An. Bras. Dermatol.

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This paper reviews the diagnostic and classificatory concepts of mycosis fungoides and Sézary syndrome in light of the latest normative publications. It describes the great variability of the clinical expression of mycosis fungoides in its early stages as well as the histopathological and immunohistochemical aspects that help with diagnosis. The diagnostic criteria required for characterizing Sézary syndrome and the staging system used for both mycosis fungoides and Sézary syndrome are described.

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Invisible mycosis fungoides: A diagnostic challenge

Cited by 46 publications

References 20 publications

Mycosis fungoides involving an acrochordon: a case report

Mycosis fungoides involving an acrochordon: a case report

Pruritus as a leading symptom: clinical characteristics and quality of life in German and Ugandan patients

Mycosis fungoides and Sézary syndrome: clinical, histopathological and immunohistochemical review and update

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