Invisible shield: Review of the corneal epithelium as a barrier to UV radiation, pathogens, and other environmental stimuli

Bashir, Hasan; Seykora, John T.; Lee, Vivian

doi:10.4103/jovr.jovr_114_17

Cited by 42 publications

(16 citation statements)

References 97 publications

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“…Ocular surface is composed of cornea and conjunctivas which are not only protect the eye but also enable vision. The coronal epithelium is the most important external surface of the cornea damage to this highly specialized structure leads to the vision loss [48]. Diabetes is the main cause of the blindness.…”

Section: Corneamentioning

confidence: 99%

Restoring Vision by Regenerative Medicine Using Stem Cell: A Review

Rk¹,

Ibrahim²,

Shafiq³

et al. 2018

J Biomol Res Ther

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Restoring vision is the most important center of attention of our research program, On the other hand, to attain our objective and convey the preeminent eminence of stem cell therapy; we have to understand the fundamental biology of stem cells. (RPE) Retinal Pigmented epithelium layer degenerates and contributing to a succession of actions resulting in visual impairments. Regenerative medicine holds promise for the spanning almost for all body system and the eye is an ideal organ to use in research because it is the only part of nervous system that is the visible and easily accessible. This review outlines advances in therapy and the main spotlight for the improvement and advance of cell therapies that are being confronted today.

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Section: Corneamentioning

confidence: 99%

Restoring Vision by Regenerative Medicine Using Stem Cell: A Review

Rk¹,

Ibrahim²,

Shafiq³

et al. 2018

J Biomol Res Ther

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“…The ocular surface receives approximately 59–77% of UV light directed to the head. The tear film absorbs wavelengths up to 300 nm, covering much of the UV-B spectrum [ 8 ]. In general, shorter wavelengths of UV and visible light penetrate tissues less than longer wavelengths [ 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…The cornea has a high absorption coefficient for UV-B radiation and represents a natural UV-B filter [ 14 ], absorbing up to 92% of UV-B at 300 nm, but only 20−40% of UV-A [ 8 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Corneal UV Protective Effects of a Topical Antioxidant Formulation: A Pilot Study on In Vivo Rabbits

Palazzo

Vizzarri

Ondruška

et al. 2020

IJMS

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This study aimed to evaluate the protective effect of a topical antioxidant and ultraviolet (UV) shielding action formulation containing riboflavin and D-α-tocopherol polyethylene glycol succinate (TPGS) vitamin E against corneal UV-induced damage in vivo rabbit eyes. In vivo experiments were performed using male albino rabbits, which were divided into four groups. The control group (CG) did not receive any UV irradiation; the first group (IG) was irradiated with a UV-B−UV-A lamp for 30 min; the second (G30) and third (G60) groups received UV irradiation for 30 and 60 min, respectively, and were topically treated with one drop of the antioxidant and shielding formulation every 15 min, starting one hour before irradiation, until the end of UV exposure. The cornea of the IG group showed irregular thickening, detachment of residual fragments of the Descemet membrane, stromal fluid swelling with consequent collagen fiber disorganization and disruption, and inflammation. The cornea of the G30 group showed edema, a mild thickening of the Descemet membrane without fibrillar collagen disruption and focal discoloration, or inflammation. In the G60 group, the cornea showed a more severe thickening, a more abundant fluid accumulation underneath the Descemet membrane with focal detachment, and no signs of severe tissue alterations, as were recorded in the IG group. Our results demonstrate that topical application of eye drops containing riboflavin and TPGS vitamin E counteracts UV corneal injury in exposed rabbits.

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“…Ocular surface receives about 59% to 77% of UV light directed to the head. The tear film absorbs wavelengths up to 300 nm, covering much of UV-B spectrum [9]. In general, shorter wavelengths of UV and visible light penetrate tissues less than longer wavelengths [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…Cornea has a high absorption coefficient for UV-B radiation and represents a natural UV-B filter [15], absorbing approximately up to 92% of UV-B at 300 nm, but only 20-40% of the UV-A [9,16].…”

Section: Introductionmentioning

confidence: 99%

Corneal UV Protective Effects Of A Topical Antioxidant Formulation: A Pilot Study On In Vivo Rabbits

Bartollino

Vizzarri

Palazzo

et al. 2019

Preprint

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Background The purpose of this study has been to evaluate the protective effect of a topical antioxidant and UV schielding action formulation containing riboflavin, d-α-tocopheryl polyethylene glycol (TPGS vitamin E), against corneal UV-induced damage in vivo rabbit eyes. Methods For the evaluation, in vivo experiments were performed using twelve male albino rabbits. Animals were divided into 4 groups of 3 animals each: control group (CG) didn’t receive any UV irradiation; the first group (IG) was irradiated with an UV-B - UV-A lamp for 30 min; the second (IG30) and the third (IG60) groups received UV irradiation for 30 and 60 minutes, respectively, and were topically treated with 1 drop (approximately 50 µl) of the antioxidant and shielding formulation every 15 minutes, starting one hour before irradiation, until the end of UV exposure. Results The cornea of IG group showed irregular thickening, detachment of residual fragments of the Descemet membrane, stromal fluid swelling with consequent collagen fibers disorganization and disruption, and inflammation. The cornea of G30 group showed edema, a mild thickening of Descemet membrane without fibrillar collagen disruption and focal discoloration, nor inflammation. In the G60 group cornea showed a more severe thickening of the cornea, a more abundant fluid accumulation underneath the Descemet membrane, with focal detachment of the same, and no signs of severe tissue alterations, as those recorded in the IG group. Conclusion Our results demonstrate that a topical application of eye drops containing riboflavin, d-α-tocopheryl polyethylene glycol (TPGS vitamin E) counteracts UV corneal injury in exposed rabbits.

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Invisible shield: Review of the corneal epithelium as a barrier to UV radiation, pathogens, and other environmental stimuli

Cited by 42 publications

References 97 publications

Restoring Vision by Regenerative Medicine Using Stem Cell: A Review

Restoring Vision by Regenerative Medicine Using Stem Cell: A Review

Corneal UV Protective Effects of a Topical Antioxidant Formulation: A Pilot Study on In Vivo Rabbits

Corneal UV Protective Effects Of A Topical Antioxidant Formulation: A Pilot Study On In Vivo Rabbits

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