In this study, effects of precursor materials and hydrothermal reaction time on the morphology, microstructures and photocatalytic activity of TiO 2 nanotubes (TNTs) were investigated. Results show that the selection of nanopowder TiO 2 precursors and hydrothermal time has significantly affected the morphology, microstructure and photocatalytic property of TiO 2 nanotubes. TNTs-Merck was fabricated from TiO 2 -Merck precursor at 130 °C for 22 h possesses a uniform structure with a range of the diameter of ~ 10 nm and length of ~ 100 nm.