Invited Faculty Abstracts from the International Neuromodulation Society’s 14th World Congress

Thuvarakan, Kenoja; Gazerani, Parisa; Zimmermann, H.

doi:10.1111/ner.12958

Cited by 6 publications

(6 citation statements)

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“…The sample size was calculated based on a previous pilot test carried out on seven healthy volunteers [ 21 ]. For an expected between-group mean difference (MD) in the PPT of 10.3 N/cm 2 with a standard deviation (SD) of 11.3 N/cm 2 in the experimental group and SD 9.9 N/cm 2 in the control group and considering a type I error (α) of 0.05 and a power of 80%, the sample size was estimated to be 17 subjects per group ( n = 17).…”

Section: Methodsmentioning

confidence: 99%

“…Additionally, percutaneous stimulation can avoid the inconveniences associated with the surgical implantation of electrodes, such as scars or additional procedures to replace them [ 19 ]. This intervention has been shown to be safe and with minimum risks in low- [ 20 ] and high-frequency [ 21 ] electrical stimulations. The main aim of this trial is to assess the effect of percutaneous electric stimulation with 10 kHz and 20 kHz HFAC applied to the median nerve compared to the sham stimulation on the motor response, somatosensory thresholds, and peripheral nerve conduction in healthy volunteers.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Percutaneous Electric Stimulation with High-Frequency Alternating Currents on the Sensory-Motor System of Healthy Volunteers: A Double-Blind Randomized Controlled Study

Álvarez

Serrano-Muñóz

Fernández-Pérez

et al. 2022

JCM

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Former studies investigated the application of high-frequency alternating currents (HFAC) in humans for blocking the peripheral nervous system. The present trial aims to assess the effect of HFAC on the motor response, somatosensory thresholds, and peripheral nerve conduction when applied percutaneously using frequencies of 10 kHz and 20 kHz in healthy volunteers. A parallel, placebo-controlled, double-blind, randomized clinical trial was conducted. Ultrasound-guided HFAC at 10 kHz and 20 kHz and sham stimulation were delivered to the median nerve of 60 healthy volunteers for 20 min. The main assessed variables were the maximum isometric flexion strength (MFFS) of the index finger, myotonometry, pressure pain threshold (PPT), mechanical detection threshold (MDT), and sensory nerve action potential (SNAP). A decrease in the MFFS is observed immediately postintervention compared to baseline, both in the 10 kHz group (−8.5%; 95% CI −14.9 to −2.1) and the 20 kHz group (−12.0%; 95% CI −18.3 to −5.6). The between-group comparison of changes in MFFS show a greater reduction of −10.8% (95% CI −19.8 to −1.8) immediately postintervention in the 20 kHz compared to the sham stimulation group. The percutaneous stimulation applying 20 kHz HFAC to the median nerve produces a reversible postintervention reduction in strength with no adverse effects.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Percutaneous Electric Stimulation with High-Frequency Alternating Currents on the Sensory-Motor System of Healthy Volunteers: A Double-Blind Randomized Controlled Study

Álvarez

Serrano-Muñóz

Fernández-Pérez

et al. 2022

JCM

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“…Research investigating the impact of 10 kHz SCS on medication consumption is promising (19,20). Opioid consumption appears to decrease with 10 kHz SCS (5,13,15,(21)(22)(23)(24)(25)(26). Additionally, greater decreases in opioid use compared to conventional SCS (14,16) and conventional medical management (27) have been observed.…”

Section: Introductionmentioning

confidence: 99%

One-Year Results of Prospective Research Study Using 10 kHz Spinal Cord Stimulation in Persistent Nonoperated Low Back Pain of Neuropathic Origin: Maiden Back Study

Baranidharan

Feltbower

Bretherton

et al. 2021

Neuromodulation: Technology at the Neural Interface

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“…Although both procedures have shown positive results, they entail risks derived from additional interventions to replace electrodes ( Finch et al, 2019 ). The ultrasound-guided percutaneous application of currents can be considered a minimally invasive procedure ( Boyce et al, 2020 ) that allows reducing the distance between the electrode and nerve ( Williamson and Andrews, 2005 ) and has proven to be a safe method with minimum associated risks ( Eldabe et al, 2016 ; No author list, 2019 ). Our research group observed in a pilot study that the percutaneous ultrasound-guided application of 20 kHz HFAC to the median nerve was a feasible, safe procedure with minimal risks and with a potential effect on the pressure pain threshold (PPT) ( No author list, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

“…The ultrasound-guided percutaneous application of currents can be considered a minimally invasive procedure ( Boyce et al, 2020 ) that allows reducing the distance between the electrode and nerve ( Williamson and Andrews, 2005 ) and has proven to be a safe method with minimum associated risks ( Eldabe et al, 2016 ; No author list, 2019 ). Our research group observed in a pilot study that the percutaneous ultrasound-guided application of 20 kHz HFAC to the median nerve was a feasible, safe procedure with minimal risks and with a potential effect on the pressure pain threshold (PPT) ( No author list, 2019 ). The outcomes of another recent study that applied ultrasound-guided HFAC at 10 and 20 kHz via needle electrodes showed that this safe procedure produced a decrease in the maximum handgrip strength using 20 kHz, but not 10 kHz, without any changes being observed in any somatosensory threshold ( Álvarez et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of percutaneous electrical stimulation with high-frequency alternating currents at 30 kHz on the sensory-motor system

Álvarez

Serrano-Muñóz²,

Fernández-Pérez³

et al. 2023

Front. Neurosci.

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BackgroundUnmodulated high-frequency alternating currents (HFAC) are employed for producing peripheral nerves block. HFAC have been applied in humans with frequencies up to 20 kHz, whether transcutaneously, percutaneously, or via surgically-implanted electrodes. The aim of this study was to assess the effect of percutaneous HFAC, applied with ultrasound-guided needles at 30 kHz, on the sensory-motor nerve conduction of healthy volunteers.MethodsA parallel, double-blind, randomized clinical trial with a placebo control was conducted. Percutaneous HFAC at 30 kHz or sham stimulation was applied via ultrasound-guided needles in 48 healthy volunteers (n = 24 in each group) for 20 min. The assessed outcome variables were pressure pain threshold (PPT), mechanical detection threshold (MDT), maximal finger flexion strength (MFFS), antidromic sensory nerve action potential (SNAP), hand temperature, and subjective sensations by the participants. The measurements were recorded pre-intervention, during the stimulation (at 15 min), immediately post-intervention (at 20 min), and 15 min after the end of treatment.ResultsThe PPT increased in the active group compared with sham stimulation, both during the intervention [14.7%; 95% confidence interval (CI): 4.4–25.0], immediately post-intervention (16.9%; 95% CI: −7.2–26.5), and 15 min after the end of the stimulation (14.3%; 95% CI: 4.4–24.3) (p < 0.01). The proportion of participants who reported feelings of numbness and heaviness was significantly higher in the active group (46 and 50%, respectively) than in the sham group (8 and 18%, respectively) (p < 0.05). No intergroup differences were observed in the remaining outcome variables. No unexpected adverse effects derived from the electrical stimulation were reported.ConclusionPercutaneous stimulation with HFAC at 30 kHz applied to the median nerve increased the PPT and subjective perception of numbness and heaviness. Future research should evaluate its potential therapeutic effect in people with pain.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/NCT04884932, identifier NCT04884932.

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Invited Faculty Abstracts from the International Neuromodulation Society’s 14th World Congress

Cited by 6 publications

References 0 publications

Effect of Percutaneous Electric Stimulation with High-Frequency Alternating Currents on the Sensory-Motor System of Healthy Volunteers: A Double-Blind Randomized Controlled Study

Effect of Percutaneous Electric Stimulation with High-Frequency Alternating Currents on the Sensory-Motor System of Healthy Volunteers: A Double-Blind Randomized Controlled Study

One-Year Results of Prospective Research Study Using 10 kHz Spinal Cord Stimulation in Persistent Nonoperated Low Back Pain of Neuropathic Origin: Maiden Back Study

Effect of percutaneous electrical stimulation with high-frequency alternating currents at 30 kHz on the sensory-motor system

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