Invitro evaluation of piperine enclosed erythrocyte carriers

Ribavirin Loaded Erythrocytes by Endocytosis as Targeted Drug Carrier System

“…The osmotic fragility index for normal erythrocytes was found to be 0.486% w/v, for sham was found to be 0.409 % w/v and for loaded erythrocytes was found to be 0.394% w/v. There was a slight decrease in the osmotic fragility index value and was found to be very negligible to be considered 9 .The observed data were in a good agreement with the work done by Madhavi et al, who stated that osmotic fragility of Piperine loaded erythrocytes is decreased compared with that of unloaded cells and sham erythrocytes. The observed results indicate that the osmotic fragility of Ribavirin-loaded erythrocytes are affected by two factors, loading process and Ribavirin as drug cause change in erythrocytes membrane.…”

“…Erythrocytes are preferred as a drug carrier system because they have many advantages as availability in abundant cells in the body, biocompatibility, biodegradability, loading with a variety of drugs 4 and considerable circulation life-span of the auto logous carrier erythrocytes which allow them to serve as prolonged release intravenous reservoirs for various drugs 1,5,6 . On the other hand, abnormal or aged erythrocytes are destructed or phagocytosed by the RES and they can be used as drug targeting carriers to RES organs mainly liver, spleen and kidney [7][8][9][10] . The drugs or bioactive substances can be successfully loaded or entrapped into erythrocytes by different methods as osmosis based method (e.g.…”

Anti-microbial activity of Ocimum sanctum L. gel against black pigmented microbes

“…[ 8 ] The goal of developing herbal remedies was to reduce the resistance of some microorganisms to antimicrobial agents as well as to minimize unfavourable side effects and expensive treatment options. [ 9 ] Thousands of phytochemicals are produced by plants, and there are numerous methods to raise the quantities of bioactive products in the plant and get chemically assimilated extract. [ 10 ] O. sanctum , popularly referred to as tulsi in India, is said to be a significant foundation of the Ayurvedic holistic healing system.…”

Impact of breast cancer neoadjuvant chemotherapy on plasma and urine amino acid profile, plasma proteins and nitrogen metabolism

“…In addition to the investigation of the mechanisms underlying the antitumor effect of individual treatment regimens and the possibilities for regimen optimization, toxic side effects were also investigated [6,7] Numerous studies have examined changes in laboratory parameters caused by the underlying tumor disease and those caused by antitumor treatment, often with con icting results. The focus of clinical trials investigating the effect of the malignancy itself, a side effect of chemotherapy, or a combination of both can be categorized into three areas: plasma and urine amino acid [8][9][10][11][12][13][14][15][16][17][18][19][20]; plasma protein synthesis and degradation and nitrogen balance [21][22][23][24][25]; catabolism and energy expenditure [26][27][28][29][30][31][32][33]; and weight changes, body composition, and sarcopenia [34][35][36][37][38]. These areas are mostly studied separately.…”